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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3t10 ACP Heat shock protein HSP 90-alpha

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3t10 ACPHeat shock protein HSP 90-alpha / 0.931
3t1k ANPHeat shock protein HSP 90-alpha / 0.894
4xc0 ACPHeat shock cognate 90 kDa protein / 0.871
2yef ANPHeat shock protein HSP 90-alpha / 0.859
3t0z ATPHeat shock protein HSP 90-alpha / 0.856
3t2s AGSHeat shock protein HSP 90-alpha / 0.826
4gqt ADPHeat shock protein 90 / 0.818
1byq ADPHeat shock protein HSP 90-alpha / 0.813
2xk2 ADPHeat shock protein HSP 90-alpha / 0.812
4xcl AGSHeat shock cognate 90 kDa protein / 0.810
4ivg ANPTNF receptor-associated protein 1 / 0.807
4xcj ADPHeat shock cognate 90 kDa protein / 0.807
4wuc ANPDNA gyrase subunit B / 0.779
2ior ADPChaperone protein HtpG / 0.765
1mx0 ANPType 2 DNA topoisomerase 6 subunit B / 0.760
4wud ANPDNA gyrase subunit B / 0.758
5f5r ANPHeat shock protein 75 kDa, mitochondrial / 0.755
3sl2 ATPSensor histidine kinase WalK / 0.754
2xcm ADPCytosolic heat shock protein 90 / 0.753
1yt0 ADPEndoplasmin / 0.751
2e0a ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.738
3crl ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.730
2wep ADPATP-dependent molecular chaperone HSP82 / 0.726
1z5c ADPType 2 DNA topoisomerase 6 subunit B / 0.725
4prv ADPDNA gyrase subunit B / 0.722
2o1u ANPEndoplasmin / 0.715
1am1 ADPATP-dependent molecular chaperone HSP82 / 0.712
4prx ADPDNA gyrase subunit B / 0.712
3a0t ADPSensor histidine kinase / 0.707
1y4s ADPChaperone protein HtpG / 0.701
1pvg ANPDNA topoisomerase 2 5.99.1.3 0.699
4ipe ANPTNF receptor-associated protein 1 / 0.698
4r39 ANPBlue-light-activated histidine kinase 2 2.7.13.3 0.698
4gt8 ADPSensor protein VraS 2.7.13.3 0.692
3ied AN2HSP90 / 0.689
1i59 ANPChemotaxis protein CheA 2.7.13.3 0.687
3h4l ANPDNA mismatch repair protein PMS1 / 0.686
1amw ADPATP-dependent molecular chaperone HSP82 / 0.685
1nhh ANPDNA mismatch repair protein MutL / 0.679
3zkb ANPDNA gyrase subunit B / 0.677
2bu2 ATP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.676
2yeg XQGHeat shock protein HSP 90-alpha / 0.676
1qy5 NECEndoplasmin / 0.675
3zkd ANPDNA gyrase subunit B / 0.672
4xfj ANPArgininosuccinate synthase / 0.668
1z59 ADPType 2 DNA topoisomerase 6 subunit B / 0.664
3d2r ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.664
1jm6 ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.663
1gjv AGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 2.7.11.4 0.662
1i5b ANPChemotaxis protein CheA 2.7.13.3 0.661
1zxm ANPDNA topoisomerase 2-alpha 5.99.1.3 0.659
1ei1 ANPDNA gyrase subunit B / 0.658
2gqp PA7Endoplasmin / 0.658
1i58 ACPChemotaxis protein CheA 2.7.13.3 0.657
1i5a ACPChemotaxis protein CheA 2.7.13.3 0.657
2zkj ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.651