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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3t0z ATP Heat shock protein HSP 90-alpha

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3t0z ATPHeat shock protein HSP 90-alpha / 0.932
3t1k ANPHeat shock protein HSP 90-alpha / 0.881
3t10 ACPHeat shock protein HSP 90-alpha / 0.856
2yef ANPHeat shock protein HSP 90-alpha / 0.834
3t2s AGSHeat shock protein HSP 90-alpha / 0.819
4gqt ADPHeat shock protein 90 / 0.814
4xc0 ACPHeat shock cognate 90 kDa protein / 0.812
3sl2 ATPSensor histidine kinase WalK / 0.803
1byq ADPHeat shock protein HSP 90-alpha / 0.800
2xk2 ADPHeat shock protein HSP 90-alpha / 0.786
2e0a ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.783
2xcm ADPCytosolic heat shock protein 90 / 0.766
2ior ADPChaperone protein HtpG / 0.765
4wuc ANPDNA gyrase subunit B / 0.761
4wud ANPDNA gyrase subunit B / 0.755
4xcj ADPHeat shock cognate 90 kDa protein / 0.754
4xcl AGSHeat shock cognate 90 kDa protein / 0.754
1pvg ANPDNA topoisomerase 2 5.99.1.3 0.742
4gt8 ADPSensor protein VraS 2.7.13.3 0.733
5f5r ANPHeat shock protein 75 kDa, mitochondrial / 0.733
4ipe ANPTNF receptor-associated protein 1 / 0.729
1i58 ACPChemotaxis protein CheA 2.7.13.3 0.726
2o1u ANPEndoplasmin / 0.724
4prv ADPDNA gyrase subunit B / 0.723
4ivg ANPTNF receptor-associated protein 1 / 0.722
2wep ADPATP-dependent molecular chaperone HSP82 / 0.718
3h4l ANPDNA mismatch repair protein PMS1 / 0.718
3crl ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.715
4prx ADPDNA gyrase subunit B / 0.703
1yt0 ADPEndoplasmin / 0.701
1zxm ANPDNA topoisomerase 2-alpha 5.99.1.3 0.694
1z59 ADPType 2 DNA topoisomerase 6 subunit B / 0.691
4biw ANPSensor histidine kinase CpxA / 0.688
1mx0 ANPType 2 DNA topoisomerase 6 subunit B / 0.686
1i5b ANPChemotaxis protein CheA 2.7.13.3 0.685
1z5c ADPType 2 DNA topoisomerase 6 subunit B / 0.685
1nhh ANPDNA mismatch repair protein MutL / 0.684
1i5a ACPChemotaxis protein CheA 2.7.13.3 0.682
1i59 ANPChemotaxis protein CheA 2.7.13.3 0.681
3a0t ADPSensor histidine kinase / 0.672
3zkd ANPDNA gyrase subunit B / 0.671
4bix ADPSensor histidine kinase CpxA / 0.671
4r39 ANPBlue-light-activated histidine kinase 2 2.7.13.3 0.670
3ied AN2HSP90 / 0.665
4jql VJ6Heat shock protein HSP 90-alpha / 0.665
1am1 ADPATP-dependent molecular chaperone HSP82 / 0.664
1gjv AGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 2.7.11.4 0.664
1y4s ADPChaperone protein HtpG / 0.664
2zkj ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.662
3zkb ANPDNA gyrase subunit B / 0.657
4ww4 ADPRuvB-like helicase / 0.654
1jm6 ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.652
1s16 ANPDNA topoisomerase 4 subunit B / 0.651
1th8 ADPAnti-sigma F factor / 0.651
3d2r ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.651
3lmg ANPReceptor tyrosine-protein kinase erbB-3 2.7.10.1 0.651
4zse ANPEpidermal growth factor receptor 2.7.10.1 0.651