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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3n83 ADP Aldehyde dehydrogenase, mitochondrial 1.2.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.852
4pxl NADAldehyde dehydrogenase3 / 0.816
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.805
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.799
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.797
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.790
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.789
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.789
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.788
4pt0 NADAldehyde dehydrogenase / 0.775
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.774
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.772
4i8p NADAminoaldehyde dehydrogenase 1 / 0.767
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.766
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.765
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.763
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.763
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.761
1bi9 NADRetinal dehydrogenase 2 / 0.760
4pz2 NADAldehyde dehydrogenase 2-6 / 0.758
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.756
3b4w NADAldehyde dehydrogenase family protein / 0.756
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.756
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.751
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.746
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.744
4i8q NADPutative betaine aldehyde dehyrogenase / 0.743
2onm ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.739
4f3x NADPutative aldehyde dehydrogenase / 0.739
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.738
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.735
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.733
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.729
4i9b NADPutative betaine aldehyde dehyrogenase / 0.729
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.728
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.727
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.726
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.725
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.724
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.724
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.724
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.722
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.722
4i3v NADAldehyde dehydrogenase (NAD+) / 0.721
3iwj NADAminoaldehyde dehydrogenase / 0.720
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.719
4nmj NAPAldehyde dehydrogenase / 0.719
2w8r ADPSuccinate-semialdehyde dehydrogenase, mitochondrial 1.2.1.24 0.718
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.718
4i3w NADAldehyde dehydrogenase (NAD+) / 0.718
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.717
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.716
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.716
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.712
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.709
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.708
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.708
3rhd NAPLactaldehyde dehydrogenase 1.2.1.22 0.703
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.691
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.690
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.688
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.688
4nmk NAPAldehyde dehydrogenase / 0.687
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.686
4h73 NDPAldehyde dehydrogenase / 0.685
5eyu NADBetaine-aldehyde dehydrogenase / 0.683
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.680
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.678
2xdr NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.671
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.670
4zvy NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.668
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.665
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.665
5dib NADBetaine-aldehyde dehydrogenase / 0.665
2wme NAPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.663
3haz NADBifunctional protein PutA / 0.662
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.658
2jg7 NADAntiquitin / 0.656
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.654
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.654
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.652