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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pzp ACP Fibroblast growth factor receptor 2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2pzp ACPFibroblast growth factor receptor 2 / 1.027
2py3 ACPFibroblast growth factor receptor 2 / 1.018
2pz5 ACPFibroblast growth factor receptor 2 / 1.018
3cly ACPFibroblast growth factor receptor 2 / 0.905
4o4d ATPKinase / 0.786
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.782
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.774
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.773
4bn1 ADPAurora kinase A 2.7.11.1 0.767
4xlv ACPInsulin receptor 2.7.10.1 0.746
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.734
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.730
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.728
2pup ADPMethylthioribose kinase 2.7.1.100 0.727
1m0w ANPGlutathione synthetase 6.3.2.3 0.726
4ceg ADPAurora kinase A 2.7.11.1 0.724
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.723
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.722
5eg3 ACPFibroblast growth factor receptor 2 / 0.721
2pun ACPMethylthioribose kinase 2.7.1.100 0.719
1u54 ACPActivated CDC42 kinase 1 / 0.718
5l8j ADPAurora kinase A 2.7.11.1 0.718
4j98 ACPFibroblast growth factor receptor 2 / 0.717
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.715
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.713
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.712
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.709
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.708
4jrn ANPRhoptry kinase family protein / 0.707
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.706
4dee ADPAurora kinase A 2.7.11.1 0.706
4gyi ADPUncharacterized protein / 0.706
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.704
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.703
3orm AGSSerine/threonine protein kinase / 0.703
3nie ANPMitogen-activated protein kinase / 0.702
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.702
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.701
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.701
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.699
2pyw ADPMethylthioribose kinase 2.7.1.100 0.697
5dn3 ATPAurora kinase A 2.7.11.1 0.696
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.695
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.695
3bu5 ATPInsulin receptor 2.7.10.1 0.694
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.694
4utd ACPAurora kinase A 2.7.11.1 0.694
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.693
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.693
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.693
2pul ACPMethylthioribose kinase 2.7.1.100 0.692
5byl GCPBifunctional AAC/APH 2.3.1 0.692
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
3ori AGSSerine/threonine protein kinase / 0.690
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.689
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.688
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.688
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.687
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.685
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.685
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.684
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.684
3tw6 ADPPyruvate carboxylase / 0.684
1ol5 ADPAurora kinase A 2.7.11.1 0.683
4c3r ACPAurora kinase A 2.7.11.1 0.683
2pui ADPMethylthioribose kinase 2.7.1.100 0.682
5iqh GNPBifunctional AAC/APH 2.3.1 0.682
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.681
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.681
4j97 ACPFibroblast growth factor receptor 2 / 0.681
4q5j ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.681
5dos ATPAurora kinase A 2.7.11.1 0.681
5drd ATPAurora kinase A 2.7.11.1 0.681
3c4w ATPRhodopsin kinase / 0.680
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.680
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.679
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.679
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
5dt3 ATPAurora kinase A 2.7.11.1 0.679
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.677
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.677
1mq4 ADPAurora kinase A 2.7.11.1 0.676
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.676
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.675
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.675
5dr2 ATPAurora kinase A 2.7.11.1 0.675
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.674
3fzp AGSProtein-tyrosine kinase 2-beta 2.7.10.2 0.674
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.673
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.673
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.673
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.672
1pkg ADPMast/stem cell growth factor receptor Kit 2.7.10.1 0.671
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.671
5l8k ADPAurora kinase A 2.7.11.1 0.671
5l8l ADPAurora kinase A 2.7.11.1 0.671
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.670
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.670
4jvj 1MVFarnesyl pyrophosphate synthase 2.5.1.10 0.670
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.670
2olc ADPMethylthioribose kinase 2.7.1.100 0.668
3b2t M33Fibroblast growth factor receptor 2 / 0.668
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.667
2pvy ACPFibroblast growth factor receptor 2 / 0.666
2vqd AP2Biotin carboxylase 6.3.4.14 0.666
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.666
3qc9 ADPRhodopsin kinase / 0.666
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.666
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.666
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.665
2dwb ANPAurora kinase A 2.7.11.1 0.664
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.664
1ol6 ATPAurora kinase A 2.7.11.1 0.663
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.663
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.662
3kn5 ANPRibosomal protein S6 kinase alpha-5 2.7.11.1 0.662
3g8c ADPBiotin carboxylase 6.3.4.14 0.661
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.661
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.661
3c50 ADPRhodopsin kinase / 0.660
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.660
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.659
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.659
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.658
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.657
3q5i ANPProtein kinase, putative / 0.657
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.657
4n57 ADPAPH(2'')-Id / 0.657
2pml ANPUncharacterized protein / 0.656
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.656
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.655
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.655
3rv4 ADPBiotin carboxylase 6.3.4.14 0.655
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.654
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.654
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.653
5iqb GNPBifunctional AAC/APH 2.3.1 0.653
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.652
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.652
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.651
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.651
2ddo ATPPyridoxine/pyridoxal/pyridoxamine kinase / 0.651
3zo1 SIJcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.650
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.650
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.650
5dnr ATPAurora kinase A 2.7.11.1 0.650