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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pvr ANP Casein kinase II subunit alpha 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2pvr ANPCasein kinase II subunit alpha 2.7.11.1 0.795
5cu6 ATPCasein kinase II subunit alpha 2.7.11.1 0.750
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4ix6 ADPUncharacterized protein / 0.707
4ix4 ADPUncharacterized protein / 0.703
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.695
3b2t M33Fibroblast growth factor receptor 2 / 0.694
5ce3 ADPProtein kinase YopO / 0.693
2pml ANPUncharacterized protein / 0.687
5i4n ATPTyrosine-protein kinase JAK2 / 0.686
3pls ANPMacrophage-stimulating protein receptor 2.7.10.1 0.680
2w5b AGSSerine/threonine-protein kinase Nek2 2.7.11.1 0.679
5ckw ANPUncharacterized protein / 0.679
1fin ATPCyclin-dependent kinase 2 2.7.11.22 0.677
2eb3 ANPEpidermal growth factor receptor 2.7.10.1 0.677
2w5a ADPSerine/threonine-protein kinase Nek2 2.7.11.1 0.677
3cok ANPSerine/threonine-protein kinase PLK4 2.7.11.21 0.676
5csh ATPCasein kinase II subunit alpha 2.7.11.1 0.675
4dca ADPAminoglycoside phosphotransferase / 0.674
2pvy ACPFibroblast growth factor receptor 2 / 0.672
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
3t8o ATPRhodopsin kinase / 0.671
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.671
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.670
2eva ADNMitogen-activated protein kinase kinase kinase 7 2.7.11.25 0.670
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.670
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.669
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.669
3hx4 ANPCalmodulin-domain protein kinase 1 / 0.669
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.668
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.667
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.667
4wh3 ATPN-acetylhexosamine 1-kinase 2.7.1.162 0.666
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.663
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.663
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.663
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
1i44 ACPInsulin receptor 2.7.10.1 0.662
2vwi ANPSerine/threonine-protein kinase OSR1 2.7.11.1 0.662
2z02 ATPPhosphoribosylaminoimidazole-succinocarboxamide synthase 6.3.2.6 0.662
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.662
4n57 ADPAPH(2'')-Id / 0.662
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.661
1iah ADPTransient receptor potential cation channel subfamily M member 7 2.7.11.1 0.660
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.660
4uya AGSMitogen-activated protein kinase kinase kinase 21 2.7.11.25 0.660
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.659
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
4xhg ADPUncharacterized protein / 0.659
2p0a ANPSynapsin-3 / 0.658
4b8l A0PAurora kinase B-A 2.7.11.1 0.658
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.658
3zo1 SIJcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
3zxt ACPDeath-associated protein kinase 1 2.7.11.1 0.656
5l8j ADPAurora kinase A 2.7.11.1 0.656
1ia9 ANPTransient receptor potential cation channel subfamily M member 7 2.7.11.1 0.655
3c4x ATPRhodopsin kinase / 0.655
4ix5 ANPUncharacterized protein / 0.654
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.654
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.653
4ogr ADNCyclin-dependent kinase 9 2.7.11.22 0.653
5dr2 ATPAurora kinase A 2.7.11.1 0.653
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.651
4dee ADPAurora kinase A 2.7.11.1 0.651
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
3w0q ANPHygromycin-B 4-O-kinase 2.7.1.163 0.650
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.650
4fvq ATPTyrosine-protein kinase JAK2 / 0.650
5cnn ANPEpidermal growth factor receptor 2.7.10.1 0.650