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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2idz ZID Enoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2idz ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.190
2ieb ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.123
2ie0 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.101
2nv6 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.066
4dre NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.962
2aqh NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.959
2aq8 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.958
2aqk NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.947
3of2 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.947
3oey NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.945
4bqp NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.940
2aqi NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.929
4m87 NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.916
4zju NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.912
4dti NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.911
2b35 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.910
4bii NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.902
4dqu NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.899
2ntv P1HEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.897
5koi NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.891
2h9i EADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.886
2pr2 DG1Enoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.882
2ntj P1HEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.862
3uic NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.857
5cpb NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.851
2b37 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.849
4bgi NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.826
2wyv NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.824
4oxy NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.822
3s55 NADPutative short-chain dehydrogenase/reductase / 0.802
3w8f NAD3-hydroxybutyrate dehydrogenase / 0.801
1eny NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.796
2yut NAPPutative short-chain oxidoreductase / 0.784
3ijr NADOxidoreductase, short chain dehydrogenase/reductase family / 0.784
3uce NDPDehydrogenase / 0.784
4b79 NADProbable short-chain dehydrogenase / 0.781
4hp8 NAP2-deoxy-D-gluconate 3-dehydrogenase / 0.780
2ztl NADD(-)-3-hydroxybutyrate dehydrogenase / 0.779
2ztm NADD(-)-3-hydroxybutyrate dehydrogenase / 0.777
4c7k NAPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.768
3sju NDPKeto reductase / 0.767
1edo NAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic 1.1.1.100 0.762
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.761
3wds NADNADH-dependent quinuclidinone reductase / 0.758
1enz NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.750
3ak4 NADNADH-dependent quinuclidinone reductase / 0.748
3rj9 NADAlcohol dehydrogenase 1.1.1.1 0.747
4rf2 NAPNADPH dependent R-specific alcohol dehydrogenase / 0.743
2gdz NAD15-hydroxyprostaglandin dehydrogenase [NAD(+)] 1.1.1.141 0.742
2ztu NADD(-)-3-hydroxybutyrate dehydrogenase / 0.739
4qxm NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.739
4fj0 NAP17beta-hydroxysteroid dehydrogenase / 0.737
1cyd NDPCarbonyl reductase [NADPH] 2 1.1.1.184 0.736
1x7g NAPPutative ketoacyl reductase 1.3.1 0.736
3gy0 NAPNAD(P)-dependent oxidoreductase / 0.731
3p19 NDPPutative blue fluorescent protein / 0.731
3r3s NADPutative oxidoreductase / 0.731
3w8d NAD3-hydroxybutyrate dehydrogenase / 0.730
4qed NAPElxO / 0.730
2q2v NADBeta-D-hydroxybutyrate dehydrogenase / 0.729
1fdu NAPEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.728
3icp NADNAD-dependent epimerase/dehydratase / 0.727
3iah NAPPutative oxoacyl-(Acyl carrier protein) reductase / 0.726
3qrw NDPPutative ketoacyl reductase 1.3.1 0.725
1e6w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.724
3rj5 NADAlcohol dehydrogenase 1.1.1.1 0.724
3vdq NAD3-hydroxybutyrate dehydrogenase / 0.724
1n5d NDPCarbonyl reductase [NADPH] 1 / 0.723
2o23 NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.723
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.720
3bhi NAPCarbonyl reductase [NADPH] 1 1.1.1.184 0.720
5jsf NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.718
2wsb NADGalactitol dehydrogenase / 0.717
2p5y NADUDP-glucose 4-epimerase / 0.716
1x7h NDPPutative ketoacyl reductase 1.3.1 0.715
2yw9 NAPEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.715
2ztv NADD(-)-3-hydroxybutyrate dehydrogenase / 0.715
4fn4 NADShort chain dehydrogenase / 0.715
4kwh NAPReductase homolog / 0.715
1p44 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.713
1e3w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.712
3sx2 NADUncharacterized protein / 0.712
5ig2 NADShort-chain dehydrogenase/reductase SDR / 0.712
5jla NADPutative short-chain dehydrogenase/reductase / 0.711
1mg5 NAIAlcohol dehydrogenase 1.1.1.1 0.710
1w4z NAPPutative ketoacyl reductase 1.3.1 0.710
4k6f NAPPutative Acetoacetyl-CoA reductase / 0.710
4o1m NADEnoyl-acyl carrier reductase / 0.710
4z3d NDPCarbonyl reductase [NADPH] 1 1.1.1.184 0.710
1e3s NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.708
1oaa NAPSepiapterin reductase 1.1.1.153 0.708
3nug NADPyridoxal 4-dehydrogenase 1.1.1.107 0.708
4dc1 NDPPutative ketoacyl reductase 1.3.1 0.708
4iqg NAPShort-chain dehydrogenase/reductase SDR / 0.708
5jyd NADShort chain dehydrogenase / 0.708
4fj1 NAP17beta-hydroxysteroid dehydrogenase / 0.707
1xkq NDPUncharacterized protein / 0.706
1h5q NAPNADP-dependent mannitol dehydrogenase 1.1.1.138 0.705
1rwb NADGlucose 1-dehydrogenase 1.1.1.47 0.705
2dkn NAI3-alpha-hydroxysteroid dehydrogenase / 0.705
3aut NAIGlucose 1-dehydrogenase 4 1.1.1.47 0.705
3o26 NDPSalutaridine reductase / 0.705
1vl8 NAPOxidoreductase, short chain dehydrogenase/reductase family / 0.704
3ai3 NDPNADPH-sorbose reductase / 0.704
3ruc NADUDP-N-acetylglucosamine 4-epimerase / 0.703
3qwf NAP17beta-hydroxysteroid dehydrogenase / 0.702
4nbt NAD3-oxoacyl-[acyl-carrier-protein] reductase / 0.702
2c59 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.701
3rku NAPNADP-dependent 3-hydroxy acid dehydrogenase / 0.700
4dc0 NDPPutative ketoacyl reductase 1.3.1 0.699
4trn NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.698
2c54 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.695
2q2q NADBeta-D-hydroxybutyrate dehydrogenase / 0.694
4gh5 NADShort-chain dehydrogenase/reductase SDR / 0.694
4yai NAIC alpha-dehydrogenase / 0.693
4o0l NDPNADPH-dependent 3-quinuclidinone reductase / 0.691
4wec NADShort chain dehydrogenase / 0.691
3l77 NJPShort-chain alcohol dehydrogenase / 0.690
1v35 NAIEnoyl-ACP reductase / 0.688
3tsc NADUncharacterized protein / 0.688
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.687
1gee NADGlucose 1-dehydrogenase 1.1.1.47 0.685
3ai2 NDPNADPH-sorbose reductase / 0.685
3d3w NAPL-xylulose reductase 1.1.1.10 0.685
4clo NAPPteridine reductase / 0.685
1gco NADGlucose 1-dehydrogenase 1.1.1.47 0.684
2d1y NADOxidoreductase, short-chain dehydrogenase/reductase family / 0.684
2dte NAIGlucose 1-dehydrogenase related protein / 0.684
4dmm NAP3-oxoacyl-[acyl-carrier-protein] reductase / 0.684
3oew NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.683
4qec NAPElxO / 0.683
4hwk NAPSepiapterin reductase 1.1.1.153 0.681
1nff NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.680
4nbu NAI3-oxoacyl-(Acyl-carrier-protein) reductase / 0.679
1xg5 NAPDehydrogenase/reductase SDR family member 11 / 0.678
2yy7 NADL-threonine dehydrogenase / 0.678
3o4r NAPDehydrogenase/reductase SDR family member 4 1.1.1.184 0.678
1sby NADAlcohol dehydrogenase 1.1.1.1 0.677
5idw NAPShort-chain dehydrogenase/reductase SDR / 0.677
3ruh NADUDP-N-acetylglucosamine 4-epimerase / 0.676
4j7u NAPSepiapterin reductase 1.1.1.153 0.676
5d2e NAPMlnE / 0.676
4yag NAIC alpha-dehydrogenase / 0.675
3o03 NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) / 0.674
3wfj NAD2-dehydropantoate 2-reductase / 0.674
5js6 NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.674
4eue NAITrans-2-enoyl-CoA reductase [NADH] / 0.673
4dbz NDPPutative ketoacyl reductase 1.3.1 0.672
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.671
3ru7 NADUDP-N-acetylglucosamine 4-epimerase / 0.671
2q1w NADPutative nucleotide sugar epimerase/ dehydratase / 0.670
1ae1 NAPTropinone reductase 1 / 0.669
3tn7 NJPShort-chain alcohol dehydrogenase / 0.669
3sxp NADADP-L-glycero-D-mannoheptose-6-epimerase / 0.668
1nfr NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.666
1pr9 NAPL-xylulose reductase 1.1.1.10 0.666
1rkx NADCDP-D-glucose-4,6-dehydratase / 0.665
4j7x NAPSepiapterin reductase 1.1.1.153 0.665
1xse NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.663
2b36 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.663
3a9w NADNDP-sugar epimerase / 0.662
4fj2 NAP17beta-hydroxysteroid dehydrogenase / 0.662
1b15 NAEAlcohol dehydrogenase 1.1.1.1 0.661
1b2l NDCAlcohol dehydrogenase 1.1.1.1 0.661
3ndr NADPyridoxal 4-dehydrogenase 1.1.1.107 0.661
2ag5 NAD3-hydroxybutyrate dehydrogenase type 2 / 0.660
3a28 NADL-2,3-butanediol dehydrogenase 1.1.1.76 0.659
1zid ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.658
3aw9 NADNAD-dependent epimerase/dehydratase / 0.658
4nbw NADShort-chain dehydrogenase/reductase SDR / 0.658
1zem NADXylitol dehydrogenase / 0.657
5lc1 NADL-threonine 3-dehydrogenase / 0.657
1sny NAPLD36273p / 0.656
3rue NADUDP-N-acetylglucosamine 4-epimerase / 0.656
4u7w NDPMxaA / 0.656
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.655
1g1a NADdTDP-glucose 4,6-dehydratase / 0.652
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.651
1ek5 NADUDP-glucose 4-epimerase / 0.650
2bfo NDPPteridine reductase 1 1.5.1.33 0.650
3h4v NAPPteridine reductase 1 1.5.1.33 0.650
4fc7 NAPPeroxisomal 2,4-dienoyl-CoA reductase 1.3.1.34 0.650