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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2c20 NAD UDP-glucose 4-epimerase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2c20 NADUDP-glucose 4-epimerase / 1.289
2p5y NADUDP-glucose 4-epimerase / 0.900
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.820
4twr NADNAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase / 0.820
2q1s NAIPutative nucleotide sugar epimerase/ dehydratase / 0.819
2q1u NADPutative nucleotide sugar epimerase/ dehydratase / 0.814
3ko8 NADNAD-dependent epimerase/dehydratase / 0.810
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.797
2q1w NADPutative nucleotide sugar epimerase/ dehydratase / 0.789
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.776
2y99 NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase 1.3.1.56 0.768
1nah NADUDP-glucose 4-epimerase 5.1.3.2 0.765
2pzj NADPutative nucleotide sugar epimerase/ dehydratase / 0.760
3icp NADNAD-dependent epimerase/dehydratase / 0.759
4lis NADUDP-glucose 4-epimerase (Eurofung) / 0.755
3ehe NADUDP-glucose 4-epimerase (GalE-1) / 0.754
2yy7 NADL-threonine dehydrogenase / 0.753
3ruh NADUDP-N-acetylglucosamine 4-epimerase / 0.750
2dkn NAI3-alpha-hydroxysteroid dehydrogenase / 0.748
1i3l NADUDP-glucose 4-epimerase / 0.747
1nai NADUDP-glucose 4-epimerase 5.1.3.2 0.746
2o23 NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.738
3sxp NADADP-L-glycero-D-mannoheptose-6-epimerase / 0.735
3wmx NADNAD dependent epimerase/dehydratase / 0.735
1pr9 NAPL-xylulose reductase 1.1.1.10 0.734
3ru7 NADUDP-N-acetylglucosamine 4-epimerase / 0.734
3pvz NADUDP-N-acetylglucosamine 4,6-dehydratase / 0.733
3lu1 NADUDP-N-acetylglucosamine 4-epimerase / 0.729
2d1y NADOxidoreductase, short-chain dehydrogenase/reductase family / 0.726
1nff NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.724
3ruf NADUDP-N-acetylglucosamine 4-epimerase / 0.722
3rua NADUDP-N-acetylglucosamine 4-epimerase / 0.718
3ru9 NADUDP-N-acetylglucosamine 4-epimerase / 0.716
1orr NADCDP-paratose 2-epimerase / 0.715
3aw9 NADNAD-dependent epimerase/dehydratase / 0.715
4gll NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.715
1ek5 NADUDP-glucose 4-epimerase / 0.713
3sx2 NADUncharacterized protein / 0.713
1iy8 NADLevodione reductase / 0.710
3ruc NADUDP-N-acetylglucosamine 4-epimerase / 0.705
4nbt NAD3-oxoacyl-[acyl-carrier-protein] reductase / 0.705
3pgx NADUncharacterized NAD-dependent oxidoreductase MAP_4146 / 0.700
1e3w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.699
1eq2 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.697
3a9w NADNDP-sugar epimerase / 0.697
4pvd NDPNADPH-dependent methylglyoxal reductase GRE2 / 0.697
3qvs NADMyo-inositol-1-phosphate synthase (Ino1) / 0.696
2bgm NAJSecoisolariciresinol dehydrogenase 1.1.1.331 0.695
4egb NADdTDP-glucose 4,6-dehydratase / 0.695
2c54 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.694
2wdz NADGalactitol dehydrogenase / 0.694
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.694
2x86 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.693
2b69 NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.692
4u7w NDPMxaA / 0.692
4lk3 NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.690
4yr9 NADL-threonine 3-dehydrogenase, mitochondrial 1.1.1.103 0.690
1n5d NDPCarbonyl reductase [NADPH] 1 / 0.689
4m55 NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.689
2p5u NADUDP-glucose 4-epimerase / 0.688
1zem NADXylitol dehydrogenase / 0.687
3sj7 NDP3-oxoacyl-(Acyl-carrier-protein) reductase, putative / 0.687
3uxy NADShort-chain dehydrogenase/reductase SDR / 0.687
3h2s NDPPutative NADH-flavin reductase / 0.686
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.686
1bxk NADdTDP-glucose 4,6-dehydratase 2 / 0.685
1nfr NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.684
2yut NAPPutative short-chain oxidoreductase / 0.684
2ydx NAPMethionine adenosyltransferase 2 subunit beta / 0.683
2ztl NADD(-)-3-hydroxybutyrate dehydrogenase / 0.683
3mje NDPAmphB / 0.682
3geg NADShort-chain dehydrogenase/reductase SDR / 0.681
3mht SAHModification methylase HhaI 2.1.1.37 0.681
5jsf NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.681
2c59 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.680
3rfx NADUronate dehydrogenase / 0.680
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.679
3ajr NADNDP-sugar epimerase / 0.679
2ggs NDPdTDP-4-dehydrorhamnose reductase / 0.678
4hxy NDPPlm1 / 0.678
1sny NAPLD36273p / 0.677
2o06 MTASpermidine synthase 2.5.1.16 0.676
4hwk NAPSepiapterin reductase 1.1.1.153 0.676
1d2h SAHGlycine N-methyltransferase 2.1.1.20 0.675
5ccx SAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220 0.675
1pzh NADLactate dehydrogenase / 0.674
2hmv ADPKtr system potassium uptake protein A / 0.674
3s55 NADPutative short-chain dehydrogenase/reductase / 0.674
1mg5 NAIAlcohol dehydrogenase 1.1.1.1 0.673
1u7t NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.673
3ec7 NADInositol 2-dehydrogenase / 0.673
3qwf NAP17beta-hydroxysteroid dehydrogenase / 0.673
1rwb NADGlucose 1-dehydrogenase 1.1.1.47 0.672
3ijr NADOxidoreductase, short chain dehydrogenase/reductase family / 0.670
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.669
2c29 NAPDihydroflavonol 4-reductase / 0.668
3r3s NADPutative oxidoreductase / 0.668
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.667
2ekp NAD2-deoxy-D-gluconate 3-dehydrogenase / 0.667
3a1n NADNDP-sugar epimerase / 0.666
3rj5 NADAlcohol dehydrogenase 1.1.1.1 0.666
3sju NDPKeto reductase / 0.665
1n2s NAIdTDP-4-dehydrorhamnose reductase 1.1.1.133 0.664
2q2v NADBeta-D-hydroxybutyrate dehydrogenase / 0.664
4j7x NAPSepiapterin reductase 1.1.1.153 0.664
3qow SAMHistone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.662
3qrw NDPPutative ketoacyl reductase 1.3.1 0.662
2ji9 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.661
2p35 SAHTrans-aconitate 2-methyltransferase / 0.661
5ccb SAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220 0.661
1rkx NADCDP-D-glucose-4,6-dehydratase / 0.660
3rud NADUDP-N-acetylglucosamine 4-epimerase / 0.660
4yag NAIC alpha-dehydrogenase / 0.660
4iv8 SAMPhosphoethanolamine N-methyltransferase,putative / 0.659
3orf NADDihydropteridine reductase 1.5.1.34 0.658
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.658
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.658
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.658
5jla NADPutative short-chain dehydrogenase/reductase / 0.658
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.657
2ibt NEAModification methylase TaqI 2.1.1.72 0.656
3d3w NAPL-xylulose reductase 1.1.1.10 0.656
3nug NADPyridoxal 4-dehydrogenase 1.1.1.107 0.656
4k6f NAPPutative Acetoacetyl-CoA reductase / 0.656
1enz NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.655
2nyu SAMrRNA methyltransferase 2, mitochondrial / 0.655
3ak4 NADNADH-dependent quinuclidinone reductase / 0.655
1sow NADL-lactate dehydrogenase 1.1.1.27 0.654
1eny NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.653
2hun NAD336aa long hypothetical dTDP-glucose 4,6-dehydratase / 0.653
2z6u SAHModification methylase HhaI 2.1.1.37 0.653
3rj9 NADAlcohol dehydrogenase 1.1.1.1 0.653
4o0l NDPNADPH-dependent 3-quinuclidinone reductase / 0.653
4yac NAIC alpha-dehydrogenase / 0.653
2z95 NDPGDP-mannose 4,6-dehydratase / 0.652
7mht SAHModification methylase HhaI 2.1.1.37 0.652
1pzg A3DLactate dehydrogenase / 0.651
5je4 SAHMethyl transferase / 0.651
3lqf NADGalactitol dehydrogenase / 0.650
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.650
4i1i NADMalate dehydrogenase / 0.650