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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2a87 FAD Thioredoxin reductase 1.8.1.9

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2a87 FADThioredoxin reductase 1.8.1.9 1.251
2q7v FADThioredoxin reductase / 0.787
4gcm FADThioredoxin reductase 1.8.1.9 0.745
4hsu FADLysine-specific histone demethylase 1B 1 0.745
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.742
2bab FADPutative aminooxidase / 0.742
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.739
2q0k FADThioredoxin reductase 1.8.1.9 0.731
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.730
1ng4 FADGlycine oxidase 1.4.3.19 0.729
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.728
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.725
3r9u FADThioredoxin reductase / 0.725
4wx1 FDAUDP-galactopyranose mutase / 0.724
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.723
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.723
2b9y FADPutative aminooxidase / 0.722
3cnd FADPolyamine oxidase FMS1 / 0.722
2whd FADThioredoxin reductase / 0.721
2rgh FADAlpha-Glycerophosphate Oxidase / 0.716
4u8l FDAUDP-galactopyranose mutase / 0.716
4u8o FDAUDP-galactopyranose mutase / 0.714
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.712
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.711
3ish FADThioredoxin reductase 1.8.1.9 0.711
3uth FDAUDP-galactopyranose mutase / 0.710
1nhs FADNADH peroxidase 1.11.1.1 0.706
1vdc FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.706
5j60 FADThioredoxin reductase / 0.706
4u8k FDAUDP-galactopyranose mutase / 0.705
4u8m FDAUDP-galactopyranose mutase / 0.703
3f8d FADNADH oxidase/thioredoxin reductase / 0.701
4u8j FDAUDP-galactopyranose mutase / 0.700
3cgc FADCoenzyme A disulfide reductase / 0.699
4a5l FADThioredoxin reductase / 0.699
4cnj FADL-amino acid oxidase / 0.699
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.698
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.696
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.693
4cbq FADThioredoxin reductase / 0.692
4u8i FDAUDP-galactopyranose mutase / 0.692
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.690
3cgd FADCoenzyme A disulfide reductase / 0.689
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.689
2yg6 FADPutrescine oxidase / 0.687
3cty FADProbable thioredoxin reductase / 0.687
4u8n FDAUDP-galactopyranose mutase / 0.687
4up3 FADThioredoxin reductase / 0.686
4z26 FADPutative GMC-type oxidoreductase R135 1 0.686
1nhr FADNADH peroxidase 1.11.1.1 0.685
2h94 FADLysine-specific histone demethylase 1A 1 0.685
4dsg FADUncharacterized protein / 0.685
4gut FADLysine-specific histone demethylase 1B 1 0.685
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.685
1h81 FADPolyamine oxidase 1.5.3.14 0.684
3utf FDAUDP-galactopyranose mutase / 0.684
3itj FADThioredoxin reductase 1 1.8.1.9 0.683
4cnk FADL-amino acid oxidase / 0.683
5j4e FMNSensory box protein / 0.683
1q1w FADPutidaredoxin reductase 1.18.1.5 0.681
2yg7 FADPutrescine oxidase / 0.681
2ba9 FADPutative aminooxidase / 0.680
2ywl FADThioredoxin reductase related protein / 0.680
3k4c FADPyranose 2-oxidase / 0.679
4opd FDAConserved Archaeal protein / 0.678
4rsl FADFructosyl peptide oxidase / 0.678
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.677
4gde FDAUDP-galactopyranose mutase / 0.677
2gmj FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.676
3cge FADCoenzyme A disulfide reductase / 0.676
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.676
1c0k FADD-amino-acid oxidase 1.4.3.3 0.675
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.675
1tdo FADL-amino-acid oxidase 1.4.3.2 0.675
2b9w FADPutative aminooxidase / 0.675
2x3n FADProbable FAD-dependent monooxygenase / 0.675
3nlc FADUncharacterized protein / 0.675
4ccr FADThioredoxin reductase / 0.675
4dsh FDAUncharacterized protein / 0.675
5l3d FADLysine-specific histone demethylase 1A 1 0.674
2jb1 FADL-amino acid oxidase / 0.673
3utg FDAUDP-galactopyranose mutase / 0.673
4guu FA9Lysine-specific histone demethylase 1B 1 0.673
2bac FADPutative aminooxidase / 0.672
2jae FADL-amino acid oxidase / 0.672
2jb2 FADL-amino acid oxidase / 0.672
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.672
1ffu FADCarbon monoxide dehydrogenase medium chain / 0.671
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.671
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.670
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.669
2yg5 FADPutrescine oxidase / 0.669
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.668
1nhp FADNADH peroxidase 1.11.1.1 0.668
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.668
4fwe FADLysine-specific histone demethylase 1B 1 0.667
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.667
4a65 FADThioredoxin reductase / 0.666
5buk FADFADH2-dependent halogenase / 0.666
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.665
1cl0 FADThioredoxin reductase 1.8.1.9 0.664
2e1m FADL-glutamate oxidase / 0.664
3fmw FADOxygenase / 0.664
4eqx FADCoenzyme A disulfide reductase / 0.664
4opc FDAConserved Archaeal protein / 0.664
3ept FDAPutative FAD-monooxygenase / 0.663
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.663
4x9m FADUncharacterized protein MG039 homolog / 0.663
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.662
3sfe FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.662
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.662
4eet FMNPhototropin-2 2.7.11.1 0.661
4gdp FADPolyamine oxidase FMS1 / 0.661
5ez7 FADProbable FAD-dependent oxidoreductase PA4991 / 0.661
1trb FADThioredoxin reductase 1.8.1.9 0.660
1zk7 FADMercuric reductase 1.16.1.1 0.660
2dw4 FADLysine-specific histone demethylase 1A 1 0.660
3da1 FADGlycerol-3-phosphate dehydrogenase / 0.659
4yry FADGlutamate synthase, beta subunit / 0.659
2yg3 FADPutrescine oxidase / 0.658
4gur FADLysine-specific histone demethylase 1B 1 0.658
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.658
3k4n FADPyranose 2-oxidase / 0.657
1xpq FADPolyamine oxidase FMS1 / 0.656
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.656
3cgb FADCoenzyme A disulfide reductase / 0.656
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.655
2npx FADNADH peroxidase 1.11.1.1 0.655
3fcj FADNitroalkane oxidase 1.7.3.1 0.655
3if9 FADGlycine oxidase 1.4.3.19 0.655
4nwz FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.655
1tde FADThioredoxin reductase 1.8.1.9 0.654
4jn9 FADDepH / 0.654
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.652
2b9x FADPutative aminooxidase / 0.652
3bi5 FADPolyamine oxidase FMS1 / 0.652
4k2x FADPolyketide oxygenase/hydroxylase / 0.652
1joa FADNADH peroxidase 1.11.1.1 0.651
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.651
3fbs FADOxidoreductase / 0.651
2yvj FADFerredoxin reductase / 0.650
3t37 FADPyridoxine 4-oxidase / 0.650