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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1b16 NAQ Alcohol dehydrogenase 1.1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1b16 NAQAlcohol dehydrogenase 1.1.1.1 1.418
1b15 NAEAlcohol dehydrogenase 1.1.1.1 1.198
1mg5 NAIAlcohol dehydrogenase 1.1.1.1 1.092
3rj5 NADAlcohol dehydrogenase 1.1.1.1 1.086
1b2l NDCAlcohol dehydrogenase 1.1.1.1 1.069
3rj9 NADAlcohol dehydrogenase 1.1.1.1 1.006
1sby NADAlcohol dehydrogenase 1.1.1.1 0.902
4fj0 NAP17beta-hydroxysteroid dehydrogenase / 0.834
4o0l NDPNADPH-dependent 3-quinuclidinone reductase / 0.823
3w8d NAD3-hydroxybutyrate dehydrogenase / 0.814
2c29 NAPDihydroflavonol 4-reductase / 0.801
2o23 NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.801
1e6w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.800
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.799
3ak4 NADNADH-dependent quinuclidinone reductase / 0.789
4pvd NDPNADPH-dependent methylglyoxal reductase GRE2 / 0.789
4nbu NAI3-oxoacyl-(Acyl-carrier-protein) reductase / 0.787
4yag NAIC alpha-dehydrogenase / 0.786
3sx2 NADUncharacterized protein / 0.781
1vl8 NAPOxidoreductase, short chain dehydrogenase/reductase family / 0.775
3wds NADNADH-dependent quinuclidinone reductase / 0.775
3gy0 NAPNAD(P)-dependent oxidoreductase / 0.774
1g0n NDPTetrahydroxynaphthalene reductase 1.1.1.252 0.772
1e3w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.771
2wsb NADGalactitol dehydrogenase / 0.771
3iah NAPPutative oxoacyl-(Acyl carrier protein) reductase / 0.771
4yai NAIC alpha-dehydrogenase / 0.770
3pgx NADUncharacterized NAD-dependent oxidoreductase MAP_4146 / 0.768
3bhi NAPCarbonyl reductase [NADPH] 1 1.1.1.184 0.766
3r3s NADPutative oxidoreductase / 0.766
5idw NAPShort-chain dehydrogenase/reductase SDR / 0.763
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.761
4b79 NADProbable short-chain dehydrogenase / 0.760
5js6 NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.759
3vdq NAD3-hydroxybutyrate dehydrogenase / 0.758
3ijr NADOxidoreductase, short chain dehydrogenase/reductase family / 0.756
2p5y NADUDP-glucose 4-epimerase / 0.753
2q2v NADBeta-D-hydroxybutyrate dehydrogenase / 0.751
3p19 NDPPutative blue fluorescent protein / 0.749
4hp8 NAP2-deoxy-D-gluconate 3-dehydrogenase / 0.749
1u7t TDT3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.748
2ztm NADD(-)-3-hydroxybutyrate dehydrogenase / 0.747
4kwh NAPReductase homolog / 0.747
1ae1 NAPTropinone reductase 1 / 0.746
1x7h NDPPutative ketoacyl reductase 1.3.1 0.743
1w4z NAPPutative ketoacyl reductase 1.3.1 0.742
1e3s NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.741
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.740
1sny NAPLD36273p / 0.740
5jsf NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.740
2gdz NAD15-hydroxyprostaglandin dehydrogenase [NAD(+)] 1.1.1.141 0.739
1zem NADXylitol dehydrogenase / 0.738
2q1w NADPutative nucleotide sugar epimerase/ dehydratase / 0.738
4fj2 NAP17beta-hydroxysteroid dehydrogenase / 0.738
4nbt NAD3-oxoacyl-[acyl-carrier-protein] reductase / 0.738
4zju NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.737
4dre NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.736
2aqk NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.734
2ntj P1HEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.731
3mje NDPAmphB / 0.730
1gco NADGlucose 1-dehydrogenase 1.1.1.47 0.729
1h5q NAPNADP-dependent mannitol dehydrogenase 1.1.1.138 0.729
4is3 NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 1.17.98.1 0.729
1x7g NAPPutative ketoacyl reductase 1.3.1 0.728
5ig2 NADShort-chain dehydrogenase/reductase SDR / 0.728
4dc1 NDPPutative ketoacyl reductase 1.3.1 0.727
4dti NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.727
4z3d NDPCarbonyl reductase [NADPH] 1 1.1.1.184 0.727
2c54 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.726
2ztl NADD(-)-3-hydroxybutyrate dehydrogenase / 0.726
4m87 NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.726
2aq8 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.725
2aqh NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.725
2q2q NADBeta-D-hydroxybutyrate dehydrogenase / 0.725
2b69 NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.723
2nv6 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.723
1nff NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.722
3o26 NDPSalutaridine reductase / 0.722
4hxy NDPPlm1 / 0.722
2d1y NADOxidoreductase, short-chain dehydrogenase/reductase family / 0.721
1i3l NADUDP-glucose 4-epimerase / 0.720
2zat NAPDehydrogenase/reductase SDR family member 4 1.1.1.184 0.718
2dkn NAI3-alpha-hydroxysteroid dehydrogenase / 0.717
3ruf NADUDP-N-acetylglucosamine 4-epimerase / 0.717
3uxy NADShort-chain dehydrogenase/reductase SDR / 0.715
3ru9 NADUDP-N-acetylglucosamine 4-epimerase / 0.714
2wdz NADGalactitol dehydrogenase / 0.712
5jyd NADShort chain dehydrogenase / 0.711
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.710
1n2s NAIdTDP-4-dehydrorhamnose reductase 1.1.1.133 0.709
2b37 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.708
4gh5 NADShort-chain dehydrogenase/reductase SDR / 0.707
4hwk NAPSepiapterin reductase 1.1.1.153 0.706
2aqi NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.705
1gee NADGlucose 1-dehydrogenase 1.1.1.47 0.703
1fk8 NAD3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase 1.1.1.50 0.702
2jah NDPClavaldehyde dehydrogenase / 0.702
3ru7 NADUDP-N-acetylglucosamine 4-epimerase / 0.702
3uce NDPDehydrogenase / 0.702
4j7u NAPSepiapterin reductase 1.1.1.153 0.700
1rwb NADGlucose 1-dehydrogenase 1.1.1.47 0.699
2ggs NDPdTDP-4-dehydrorhamnose reductase / 0.699
4bmv NAPShort-chain dehydrogenase / 0.699
4u7w NDPMxaA / 0.698
4qed NAPElxO / 0.697
3rua NADUDP-N-acetylglucosamine 4-epimerase / 0.696
2ag5 NAD3-hydroxybutyrate dehydrogenase type 2 / 0.695
3ndr NADPyridoxal 4-dehydrogenase 1.1.1.107 0.695
4idg NADPutative UDP-glucose 4-epimerase / 0.692
1pr9 NAPL-xylulose reductase 1.1.1.10 0.691
2bgm NAJSecoisolariciresinol dehydrogenase 1.1.1.331 0.691
3sxp NADADP-L-glycero-D-mannoheptose-6-epimerase / 0.691
2b4q NAPRhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase 1.1.1.100 0.690
3orf NADDihydropteridine reductase 1.5.1.34 0.690
4dbz NDPPutative ketoacyl reductase 1.3.1 0.690
2c59 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.689
2ztu NADD(-)-3-hydroxybutyrate dehydrogenase / 0.689
3ruc NADUDP-N-acetylglucosamine 4-epimerase / 0.689
1n5d NDPCarbonyl reductase [NADPH] 1 / 0.688
5d2e NAPMlnE / 0.688
3oey NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.686
3rud NADUDP-N-acetylglucosamine 4-epimerase / 0.685
1cyd NDPCarbonyl reductase [NADPH] 2 1.1.1.184 0.684
2ie0 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.684
2ztv NADD(-)-3-hydroxybutyrate dehydrogenase / 0.683
3a4v NADNDP-sugar epimerase / 0.682
4cql NADEstradiol 17-beta-dehydrogenase 8 1.1.1.62 0.681
2pr2 DG1Enoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.680
3geg NADShort-chain dehydrogenase/reductase SDR / 0.680
3qrw NDPPutative ketoacyl reductase 1.3.1 0.680
3lu1 NADUDP-N-acetylglucosamine 4-epimerase / 0.679
4gll NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.679
3ruh NADUDP-N-acetylglucosamine 4-epimerase / 0.676
5lc1 NADL-threonine 3-dehydrogenase / 0.675
2ieb ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.674
4iqg NAPShort-chain dehydrogenase/reductase SDR / 0.674
3sju NDPKeto reductase / 0.673
1bdb NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase / 0.672
1bws NDPGDP-L-fucose synthase / 0.672
2q1s NAIPutative nucleotide sugar epimerase/ dehydratase / 0.672
2dte NAIGlucose 1-dehydrogenase related protein / 0.671
4clo NAPPteridine reductase / 0.671
4dmm NAP3-oxoacyl-[acyl-carrier-protein] reductase / 0.669
1p44 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.668
2nq8 ZIDEnoyl-ACP reductase / 0.668
4j7x NAPSepiapterin reductase 1.1.1.153 0.668
3tsc NADUncharacterized protein / 0.667
3tox NAPPutative oxidoreductase / 0.666
1u7t NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.663
3icp NADNAD-dependent epimerase/dehydratase / 0.662
3ai2 NDPNADPH-sorbose reductase / 0.661
2yut NAPPutative short-chain oxidoreductase / 0.659
3a1n NADNDP-sugar epimerase / 0.658
4cr8 NADN-acylmannosamine 1-dehydrogenase 1.1.1.233 0.658
4o1m NADEnoyl-acyl carrier reductase / 0.657
1eny NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.656
1xjq ADPBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 2.7.1.25 0.656
2bd0 NAPSepiapterin reductase / 0.656
1n7h NDPGDP-mannose 4,6 dehydratase 2 4.2.1.47 0.654
3zxi TYATyrosine--tRNA ligase, mitochondrial 6.1.1.1 0.654
2b35 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.652
4c7k NAPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.652
4fn4 NADShort chain dehydrogenase / 0.652
4wec NADShort chain dehydrogenase / 0.652
4i5e NAPAlclohol dehydrogenase/short-chain dehydrogenase / 0.651
4fw8 NAI3-oxoacyl-(Acyl-carrier-protein) reductase / 0.650