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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1a71 NAD Alcohol dehydrogenase E chain 1.1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 1.272
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.211
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.209
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 1.202
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.194
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 1.194
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 1.194
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 1.194
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.194
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 1.193
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 1.180
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 1.179
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 1.179
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 1.175
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 1.173
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 1.166
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 1.164
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.149
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.149
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 1.135
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 1.108
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 1.106
1het NADAlcohol dehydrogenase E chain 1.1.1.1 1.085
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 1.080
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 1.076
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 1.070
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 1.064
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 1.059
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 1.056
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 1.041
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 1.036
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.980
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.963
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.910
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.895
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.881
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.879
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.870
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.867
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.853
4c4o NADSADH / 0.853
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.843
3jv7 NADSecondary alcohol dehydrogenase / 0.829
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.825
3wle NAD(R)-specific carbonyl reductase / 0.810
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.809
4cpd NADAlcohol dehydrogenase / 0.809
1uxj NADMalate dehydrogenase / 0.804
4oaq NDPR-specific carbonyl reductase / 0.803
1yqx NAPSinapyl alcohol dehydrogenase / 0.787
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.786
1yqd NAPSinapyl alcohol dehydrogenase / 0.785
2dph NADFormaldehyde dismutase / 0.780
3two NDPMannitol dehydrogenase / 0.778
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.777
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.776
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.775
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.773
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.773
1uxk NADMalate dehydrogenase / 0.769
2voj NADAlanine dehydrogenase 1.4.1.1 0.767
1u7h NADPutative ornithine cyclodeaminase / 0.766
1x7d NADPutative ornithine cyclodeaminase / 0.762
2o4c NADErythronate-4-phosphate dehydrogenase / 0.756
4l0q NADAlcohol dehydrogenase class-3 / 0.754
4rqu NADAlcohol dehydrogenase class-P / 0.745
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.740
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.739
1gv0 NADMalate dehydrogenase / 0.736
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.733
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.733
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.732
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.730
4jji NADAlcohol dehydrogenase class-3 / 0.727
2x0i NAIMalate dehydrogenase / 0.725
1c1d NAIPhenylalanine dehydrogenase / 0.723
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.722
4ejm NAPPutative zinc-binding dehydrogenase / 0.722
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.721
2vhx NADAlanine dehydrogenase 1.4.1.1 0.721
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.719
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.717
4i1i NADMalate dehydrogenase / 0.715
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.714
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.713
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.712
4k28 NADShikimate dehydrogenase family protein / 0.708
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.708
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.703
4jk3 NADUncharacterized protein / 0.703
3ggp NADPrephenate dehydrogenase / 0.702
4b7x NAPProbable oxidoreductase / 0.701
4j43 NADUncharacterized protein / 0.701
5ees NAP4-hydroxy-tetrahydrodipicolinate reductase / 0.701
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.700
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.700
5a1t NAIL-lactate dehydrogenase / 0.700
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.698
2x0r NADMalate dehydrogenase / 0.697
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.695
4y1b NAPAntE / 0.695
2yy7 NADL-threonine dehydrogenase / 0.694
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.692
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.692
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.691
1guy NADMalate dehydrogenase / 0.690
1pzf A3DLactate dehydrogenase / 0.690
2vwh NAPGlucose 1-dehydrogenase / 0.690
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.690
1wze NADMalate dehydrogenase / 0.689
1pzg A3DLactate dehydrogenase / 0.688
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.688
4plp NADHomospermidine synthase 2.5.1.44 0.688
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.688
1up6 NAD6-phospho-beta-glucosidase BglT 3.2.1.86 0.686
2cdc NAPGlucose 1-dehydrogenase / 0.686
4xqc NADHomospermidine synthase 2.5.1.44 0.686
2y05 NAPProstaglandin reductase 1 / 0.685
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.684
1pjc NADAlanine dehydrogenase / 0.683
2cda NAPGlucose 1-dehydrogenase / 0.683
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.682
4tvb NADHomospermidine synthase 2.5.1.44 0.682
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.681
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.680
3wfj NAD2-dehydropantoate 2-reductase / 0.680
3x2f NAIAdenosylhomocysteinase / 0.679
4j49 NAIUncharacterized protein / 0.679
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.678
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.678
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.677
2gsd NADFormate dehydrogenase / 0.677
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.676
1la2 NADInositol-3-phosphate synthase 5.5.1.4 0.675
1ur5 NADMalate dehydrogenase / 0.675
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.673
3uko NADAlcohol dehydrogenase class-3 / 0.673
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.673
4j49 NADUncharacterized protein / 0.673
1pzh NADLactate dehydrogenase / 0.671
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.670
1b8v NADMalate dehydrogenase / 0.668
1f8f NADBenzyl alcohol dehydrogenase / 0.668
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.668
3d64 NADAdenosylhomocysteinase / 0.668
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.668
1efk NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.667
1ie3 NADMalate dehydrogenase / 0.667
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.667
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.667
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.666
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.666
4rvu NDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) / 0.666
1omo NADAlanine dehydrogenase / 0.665
2i9p NAD3-hydroxyisobutyrate dehydrogenase, mitochondrial 1.1.1.31 0.665
2vwq NAPGlucose 1-dehydrogenase / 0.665
3kb6 NADD-lactate dehydrogenase / 0.665
1up7 NAD6-phospho-beta-glucosidase BglT 3.2.1.86 0.664
1wzi NDPMalate dehydrogenase / 0.664
1ryd NDPGlucose--fructose oxidoreductase 1.1.99.28 0.663
3q2k NAIProbable oxidoreductase / 0.663
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.662
3ikt NADRedox-sensing transcriptional repressor Rex / 0.662
4j4b NAIUncharacterized protein / 0.662
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.662
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.661
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.661
1lsj NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.658
4xrg NADHomospermidine synthase 2.5.1.44 0.658
4jbi NDPAlcohol dehydrogenase (Zinc) / 0.657
5bqf NAPProbable hydroxyacid dehydrogenase protein / 0.657
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.656
1sow NADL-lactate dehydrogenase 1.1.1.27 0.655
2dc1 NADProbable L-aspartate dehydrogenase / 0.655
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.655
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.654
3tri NAPPyrroline-5-carboxylate reductase / 0.654
1pj3 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.653
3mvq NDPGlutamate dehydrogenase 1, mitochondrial 1.4.1.3 0.653
5a04 NDPGlucose-fructose oxidoreductase / 0.653
4gl4 NAIAlcohol dehydrogenase class-3 / 0.652
1nyt NAPShikimate dehydrogenase (NADP(+)) / 0.650
3adp NAILambda-crystallin 1.1.1.45 0.650
3f3s NADLambda-crystallin homolog / 0.650
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.650
3vdq NAD3-hydroxybutyrate dehydrogenase / 0.650
5a05 NDPGlucose-fructose oxidoreductase / 0.650