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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ju21O0Genome polyprotein2.7.7.48

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4ju21O0Genome polyprotein2.7.7.481.000
4jty1NVGenome polyprotein2.7.7.480.686
4ju11NZGenome polyprotein2.7.7.480.677
4jvq1MLGenome polyprotein2.7.7.480.647
4jtw1NUGenome polyprotein2.7.7.480.645
3cj3SX4Genome polyprotein2.7.7.480.564
2d3uCCTPolyprotein/0.558
2o5dVR1Genome polyprotein2.7.7.480.552
1nhv154Genome polyprotein2.7.7.480.532
2girNN3Genome polyprotein2.7.7.480.528
2j5xGSPADP-ribosylation factor 6/0.489
4bqpNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.469
4m9aFDAAcyl-CoA dehydrogenase/0.469
3elm24FCollagenase 33.4.240.468
1lwlDSOCamphor 5-monooxygenase1.14.15.10.467
1kt3RTLRetinol-binding protein 4/0.466
4j361HRKynurenine 3-monooxygenase/0.462
4l4xNDPAmphI/0.462
5jtbZMAAdenosine receptor A2a/0.462
1cqp803Integrin alpha-L/0.461
5k2dZMAAdenosine receptor A2a/0.461
3pqbVGPPutative oxidoreductase/0.460
4do30LAFatty-acid amide hydrolase 13.5.1.990.459
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.458
1szcCNANAD-dependent protein deacetylase HST23.5.10.455
4bvaT3Ketimine reductase mu-crystallin1.5.1.250.455
4knzCB3Thymidylate synthase/0.455
2ydoADNAdenosine receptor A2a/0.454
4iv21GREstrogen receptor/0.454
4rpgFADUDP-galactopyranose mutase5.4.99.90.454
5k2aZMAAdenosine receptor A2a/0.454
1sqvUHDCytochrome b/0.453
3b9lAZZSerum albumin/0.453
5iu86DZAdenosine receptor A2a/0.453
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.451
3n8wFLPProstaglandin G/H synthase 11.14.99.10.451
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.451
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.451
5iubCLRAdenosine receptor A2a/0.451
4eevL1XHepatocyte growth factor receptor2.7.10.10.450
4j6bPLOCytochrome P450 monooxygenase/0.450
4jlm1NNDeoxycytidine kinase2.7.1.740.450
1bqoN25Stromelysin-13.4.24.170.449
1i6xCMPcAMP-activated global transcriptional regulator CRP/0.449
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.449
2zevB71Geranylgeranyl pyrophosphate synthase/0.449
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.449
1felFENRetinol-binding protein 4/0.448
1rx1NAPDihydrofolate reductase1.5.1.30.448
2p4iMR9Angiopoietin-1 receptor2.7.10.10.448
3ntgD72Prostaglandin G/H synthase 21.14.99.10.448
3pcfFHBProtocatechuate 3,4-dioxygenase beta chain1.13.11.30.448
4fk8FADFerredoxin--NADP reductase/0.448
4j6dTESCytochrome P450 monooxygenase/0.448
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.448
1ht834CProstaglandin G/H synthase 11.14.99.10.447
1uuoBRFDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.447
2a84ATPPantothenate synthetase6.3.2.10.447
2belCBOCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
2vcmM11Isopenicillin N synthase1.21.3.10.447
3ce31FNHepatocyte growth factor receptor2.7.10.10.447
3dhcCYKN-acyl homoserine lactonase AiiA3.1.1.810.447
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.447
1a8pFADFerredoxin--NADP reductase/0.446
2ij7TPFMycocyclosin synthase1.14.21.90.446
2wo7ASVIsopenicillin N synthase1.21.3.10.446
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
4nmdFDABifunctional protein PutA/0.446
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.446
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.446
1brpRTLRetinol-binding protein 4/0.445
1kzjCB3Thymidylate synthase/0.445
1xddAAYIntegrin alpha-L/0.445
2hqpNDPDihydrofolate reductase1.5.1.30.445
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.445
3megT27Gag-Pol polyprotein2.7.7.490.445
4j6cSTRCytochrome P450 monooxygenase/0.445
4l5b1UXDeoxycytidine kinase2.7.1.740.445
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.445
1byeATAGlutathione S-transferase 12.5.1.180.444
1eqhFLPProstaglandin G/H synthase 11.14.99.10.444
1jtuLYBThymidylate synthase/0.444
1kt6RTLRetinol-binding protein 4/0.444
1l3iSAHProbable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating)/0.444
4kwi1TJReductase homolog/0.444
4l8u9AZSerum albumin/0.444
4xz3COAAcyl-CoA synthetase (NDP forming)/0.444
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
3hcrCHDFerrochelatase, mitochondrial4.99.1.10.443
4aoxFADSteroid monooxygenase/0.443
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
5k2cZMAAdenosine receptor A2a/0.443
1z7yAA5Cysteine synthase 12.5.1.470.442
2q5g1FAPeroxisome proliferator-activated receptor delta/0.442
2xvv9DNSerum albumin/0.442
4ele31IDihydrofolate reductase/0.442
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
1d3hA26Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.441
2b0m201Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.441
2g2hP16Tyrosine-protein kinase ABL12.7.10.20.441
3e8xNAPBH1520 protein/0.441
3uhmRFNUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.441
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.441
4l9q9TPSerum albumin/0.441
1dkfBMSRetinoic acid receptor alpha/0.440
2aylFLPProstaglandin G/H synthase 11.14.99.10.440
2bxmIMNSerum albumin/0.440
2hziJINTyrosine-protein kinase ABL12.7.10.20.440
4a6nFADTetX family tetracycline inactivation enzyme/0.440
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440