Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4jik1KOSerine/threonine-protein kinase Chk12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4jik1KOSerine/threonine-protein kinase Chk12.7.11.11.000
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.519
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.518
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.510
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.508
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.508
4jia1K3Tyrosine-protein kinase JAK2/0.500
4ysjADPCalmodulin-like domain protein kinase/0.497
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.491
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.491
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.491
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.487
2ckeIQUDeath-associated protein kinase 2/0.484
5av2KMPDeath-associated protein kinase 12.7.11.10.481
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.478
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
2uzbC75Cyclin-dependent kinase 22.7.11.220.476
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.476
2j0lANPFocal adhesion kinase 12.7.10.20.474
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.474
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.471
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.469
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.468
2vnwM01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.468
3gu83GUDeath-associated protein kinase 12.7.11.10.467
4bcmT7ZCyclin-dependent kinase 22.7.11.220.467
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.467
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.466
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.465
4fv6E57Mitogen-activated protein kinase 12.7.11.240.464
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.464
5dpvSKEAurora kinase A2.7.11.10.464
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.463
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.463
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.463
3my5RFZCyclin-dependent kinase 22.7.11.220.463
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.463
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
3nynSGVG protein-coupled receptor kinase 62.7.11.160.462
1jklANPDeath-associated protein kinase 12.7.11.10.461
2ijmADPFocal adhesion kinase 12.7.10.20.461
3gu7ADPDeath-associated protein kinase 12.7.11.10.461
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.460
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.460
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.459
4hge15VTyrosine-protein kinase JAK2/0.459
5av3KMPDeath-associated protein kinase 12.7.11.10.459
4grb0XGCasein kinase II subunit alpha2.7.11.10.458
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.458
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.457
3bu5ATPInsulin receptor2.7.10.10.457
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.456
3js2VM1Fibroblast growth factor receptor 1/0.456
3zo1SIJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.455
2vu3LZECyclin-dependent kinase 22.7.11.220.455
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.455
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.455
4dtaADNAPH(2'')-Id/0.455
3bqr4RBDeath-associated protein kinase 3/0.454
2w4jADPDeath-associated protein kinase 12.7.11.10.453
2yaaATPDeath-associated protein kinase 2/0.453
3cqwCQWRAC-alpha serine/threonine-protein kinase2.7.11.10.452
3mv5XFERAC-alpha serine/threonine-protein kinase2.7.11.10.451
4aqc88ATyrosine-protein kinase JAK2/0.451
4f081RSTyrosine-protein kinase JAK2/0.451
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
3nux3NVCyclin-dependent kinase 62.7.11.220.449
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.448
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.448
5dt0SKEAurora kinase A2.7.11.10.448
1ig1ANPDeath-associated protein kinase 12.7.11.10.447
1jkkANPDeath-associated protein kinase 12.7.11.10.447
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
3c4xATPRhodopsin kinase/0.447
4e6d0NUTyrosine-protein kinase JAK2/0.447
4btkDTQTau-tubulin kinase 12.7.11.10.446
3eb0DRKUncharacterized protein/0.445
3i60E86Mitogen-activated protein kinase 12.7.11.240.445
2wouZZFTGF-beta receptor type-12.7.11.300.444
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.444
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.443
3mvhWFERAC-alpha serine/threonine-protein kinase2.7.11.10.443
3t8oATPRhodopsin kinase/0.443
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.443
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.442
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.442
1k6cMK1Gag-Pol polyprotein3.4.23.160.441
2j0m4STFocal adhesion kinase 12.7.10.20.441
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.441
4jajXU1Aurora kinase A2.7.11.10.441
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.441