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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4g170VNCasein kinase I isoform gamma-32.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4g170VNCasein kinase I isoform gamma-32.7.11.11.000
4g160VMCasein kinase I isoform gamma-32.7.11.10.725
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.684
2izrBRKCasein kinase I isoform gamma-32.7.11.10.612
4hgs15GCasein kinase I isoform gamma-32.7.11.10.553
2izsBRQCasein kinase I isoform gamma-32.7.11.10.551
4ic7ANPMitogen-activated protein kinase 72.7.11.240.521
2izuP01Casein kinase I isoform gamma-32.7.11.10.514
2chlDKICasein kinase I isoform gamma-32.7.11.10.504
4bgg844Activin receptor type-12.7.11.300.499
2btsU32Cyclin-dependent kinase 22.7.11.220.498
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.498
4dgnLU2Casein kinase II subunit alpha2.7.11.10.490
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.484
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.481
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.481
4bcmT7ZCyclin-dependent kinase 22.7.11.220.481
1eh4IC1Casein kinase I homolog 12.7.11.10.480
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.480
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.480
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.480
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.480
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.480
3nynSGVG protein-coupled receptor kinase 62.7.11.160.479
2pvnP63Casein kinase II subunit alpha2.7.11.10.478
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.477
2pvhP19Casein kinase II subunit alpha2.7.11.10.477
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.477
2izt23DCasein kinase I isoform gamma-32.7.11.10.476
1pkdUCNCyclin-dependent kinase 22.7.11.220.473
3mtfA3FActivin receptor type-12.7.11.300.473
3gc9B45Mitogen-activated protein kinase 112.7.11.240.472
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.472
2w05FRTCyclin-dependent kinase 22.7.11.220.471
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.471
1fvv107Cyclin-dependent kinase 22.7.11.220.470
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.470
2vtqLZACyclin-dependent kinase 22.7.11.220.469
4kbk1QGCasein kinase I isoform delta2.7.11.10.469
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.468
2pvlP55Casein kinase II subunit alpha2.7.11.10.468
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.467
3lltANPProtein serine/threonine kinase-1/0.467
1pyePM1Cyclin-dependent kinase 22.7.11.220.466
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.466
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.463
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.463
1g5sI17Cyclin-dependent kinase 22.7.11.220.462
4hvh19RTyrosine-protein kinase JAK32.7.10.20.462
2iw84SPCyclin-dependent kinase 22.7.11.220.461
4dgo0JWCasein kinase II subunit alpha2.7.11.10.461
4hnf16WCasein kinase I isoform delta2.7.11.10.461
1oi9N20Cyclin-dependent kinase 22.7.11.220.460
2eufLQQCyclin-dependent kinase 62.7.11.220.460
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.460
3be9P04Casein kinase II subunit alpha2.7.11.10.460
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.460
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.460
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.459
3gubGUBDeath-associated protein kinase 12.7.11.10.459
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
5c8d5ADProbable transcriptional regulator/0.459
2iw94SPCyclin-dependent kinase 22.7.11.220.457
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.457
3oroAGSSerine/threonine protein kinase/0.457
1py5PY1TGF-beta receptor type-12.7.11.300.456
3ddpRC8Cyclin-dependent kinase 22.7.11.220.456
3uyt0CKCasein kinase I isoform delta2.7.11.10.456
4ez50RSCyclin-dependent kinase 62.7.11.220.456
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.455
3eb0DRKUncharacterized protein/0.455
4jr7GNPCasein kinase II subunit alpha2.7.11.10.455
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.454
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.454
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.453
2w1fL0FAurora kinase A2.7.11.10.453
3el51UNGag-Pol polyprotein/0.453
3rak03ZCyclin-dependent kinase 22.7.11.220.453
1h1r6CPCyclin-dependent kinase 22.7.11.220.452
1m2rMNYCasein kinase II subunit alpha2.7.11.10.452
2h96893Mitogen-activated protein kinase 82.7.11.240.452
3lfnA27Cyclin-dependent kinase 22.7.11.220.452
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.452
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.452
4hvi19STyrosine-protein kinase JAK32.7.10.20.452
4o0wADNAurora kinase A2.7.11.10.452
1m2pHNACasein kinase II subunit alpha2.7.11.10.451
1xjdSTUProtein kinase C theta type2.7.11.130.451
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.451
4dgmAGICasein kinase II subunit alpha2.7.11.10.451
1di8DTQCyclin-dependent kinase 22.7.11.220.450
1k6cMK1Gag-Pol polyprotein3.4.23.160.450
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.450
3nxe2NCProtease/0.450
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.450
4wsqKSAAP2-associated protein kinase 12.7.11.10.450
2in6839Wee1-like protein kinase2.7.10.20.449
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.449
2uzdC85Cyclin-dependent kinase 22.7.11.220.449
4bcoT6QCyclin-dependent kinase 22.7.11.220.449
2uzbC75Cyclin-dependent kinase 22.7.11.220.448
2vttLZDCyclin-dependent kinase 22.7.11.220.448
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.448
3c50ADPRhodopsin kinase/0.448
3w33W19Epidermal growth factor receptor2.7.10.10.448
4jqeANPCasein kinase II subunit alpha2.7.11.10.448
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.448
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.447
4anmWULCasein kinase II subunit alpha2.7.11.10.447
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4qgiROCGag-Pol polyprotein3.4.23.160.447
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.447
4y93746Tyrosine-protein kinase/0.447
1ke6LS2Cyclin-dependent kinase 22.7.11.220.446
1oiyN41Cyclin-dependent kinase 22.7.11.220.446
1vbiNADMalate/L-lactate dehydrogenase family protein/0.446
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.446
2znq401Peroxisome proliferator-activated receptor delta/0.446
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.446
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4c4jX21Dual specificity protein kinase TTK2.7.12.10.446
1ke5LS1Cyclin-dependent kinase 22.7.11.220.445
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
3s2pPMUCyclin-dependent kinase 22.7.11.220.445
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.445
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.445
4qmySTUSerine/threonine-protein kinase 242.7.11.10.445
1hvsA77Gag-Pol polyprotein/0.444
1k6tXN1Gag-Pol polyprotein3.4.23.160.444
2x9fX9FEphrin type-B receptor 42.7.10.10.444
3bheBZNGag-Pol polyprotein3.4.23.160.444
3hx4ANPCalmodulin-domain protein kinase 1/0.444
4yuqKS1Calmodulin-like domain protein kinase/0.444
5cvfATPCasein kinase II subunit alpha2.7.11.10.444
5e8wSTUTGF-beta receptor type-12.7.11.300.444
1om1IQACasein kinase II subunit alpha2.7.11.10.443
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.443
3ormAGSSerine/threonine protein kinase/0.443
3s1h56ZCyclin-dependent kinase 22.7.11.220.443
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.443
1gih1PUCyclin-dependent kinase 22.7.11.220.442
1y91CT9Cyclin-dependent kinase 22.7.11.220.442
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.442
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.442
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4bcqTJFCyclin-dependent kinase 22.7.11.220.442
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.442
4hgt15GCasein kinase I isoform delta2.7.11.10.442
1bai0Q4Gag-Pro polyprotein/0.441
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2ckeIQUDeath-associated protein kinase 2/0.441
2hog710Serine/threonine-protein kinase Chk12.7.11.10.441
2po7CHDFerrochelatase, mitochondrial4.99.1.10.441
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3friSAH16S rRNA methylase/0.441
3gxlQIGTGF-beta receptor type-12.7.11.300.441
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.441
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.441
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4wboANWRhodopsin kinase/0.441
2c5nCK8Cyclin-dependent kinase 22.7.11.220.440
2j0m4STFocal adhesion kinase 12.7.10.20.440
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.440
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.440
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.440
4eok4SPCyclin-dependent kinase 22.7.11.220.440
4fx360KCyclin-dependent kinase 22.7.11.220.440
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440