scPDB - Distribution of Cavity Similarity values of 4buv entry / Site 2

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4buv	16I	Tankyrase-2	2.4.2.30

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity
4buv	16I	Tankyrase-2	2.4.2.30	1.000
4hki	FLN	Tankyrase-2	2.4.2.30	0.721
4buf	F36	Tankyrase-2	2.4.2.30	0.687
4l33	F70	Tankyrase-2	2.4.2.30	0.674
4l2f	1V3	Tankyrase-2	2.4.2.30	0.638
4avw	G18	Tankyrase-2	2.4.2.30	0.631
4but	31F	Tankyrase-2	2.4.2.30	0.627
5aku	29F	Tankyrase-2	2.4.2.30	0.618
4kzl	20D	Tankyrase-2	2.4.2.30	0.612
4bux	F35	Tankyrase-2	2.4.2.30	0.598
4bue	JQF	Tankyrase-2	2.4.2.30	0.597
4l0i	1UW	Tankyrase-2	2.4.2.30	0.587
4buw	F33	Tankyrase-2	2.4.2.30	0.580
4bus	32F	Tankyrase-2	2.4.2.30	0.575
4l32	1VF	Tankyrase-2	2.4.2.30	0.573
4hmh	F94	Tankyrase-2	2.4.2.30	0.572
4l09	1UR	Tankyrase-2	2.4.2.30	0.569
4l2k	1V8	Tankyrase-2	2.4.2.30	0.567
4bs4	A64	Tankyrase-2	2.4.2.30	0.564
4hlm	16S	Tankyrase-2	2.4.2.30	0.562
4buu	F38	Tankyrase-2	2.4.2.30	0.561
4kzu	A73	Tankyrase-2	2.4.2.30	0.561
4l0v	1V1	Tankyrase-2	2.4.2.30	0.558
4l31	F08	Tankyrase-2	2.4.2.30	0.557
4hl5	15W	Tankyrase-2	2.4.2.30	0.553
4iue	AJ4	Tankyrase-2	2.4.2.30	0.553
4hlf	15Z	Tankyrase-2	2.4.2.30	0.549
4hlh	20D	Tankyrase-2	2.4.2.30	0.548
4hkk	AGI	Tankyrase-2	2.4.2.30	0.546
4avu	LDR	Tankyrase-2	2.4.2.30	0.538
3p0p	NNF	Tankyrase-2	2.4.2.30	0.537
4l2g	1V4	Tankyrase-2	2.4.2.30	0.534
4j21	AJ6	Tankyrase-2	2.4.2.30	0.533
4j22	AJ7	Tankyrase-2	2.4.2.30	0.533
4hkn	LU2	Tankyrase-2	2.4.2.30	0.528
4j3l	AJ5	Tankyrase-2	2.4.2.30	0.523
4krs	1SX	Tankyrase-1	2.4.2.30	0.510
4pnr	G18	Tankyrase-2	2.4.2.30	0.510
4xbf	FAD	Lysine-specific histone demethylase 1A	1	0.473
4zm6	ACO	N-acetyl-beta-D glucosaminidase	/	0.470
3uic	NAD	Enoyl-[acyl-carrier-protein] reductase [NADH]	/	0.468
4tjy	3GN	Tankyrase-2	2.4.2.30	0.468
4tkg	09L	Tankyrase-2	2.4.2.30	0.466
3dyl	PCG	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.464
3jsi	WTC	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.464
3djf	BC3	Purine nucleoside phosphorylase	/	0.462
4dvi	2IW	Tankyrase-1	2.4.2.30	0.462
1rfg	GMP	Purine nucleoside phosphorylase	2.4.2.1	0.461
3tk0	FAD	FAD-linked sulfhydryl oxidase ALR	1.8.3.2	0.460
3f4b	TCL	Enoyl-acyl carrier protein reductase	/	0.459
3u2m	FAD	FAD-linked sulfhydryl oxidase ALR	1.8.3.2	0.459
4n4v	2GY	Tankyrase-1	2.4.2.30	0.458
2dw4	FAD	Lysine-specific histone demethylase 1A	1	0.457
2yp0	OVE	2',3'-cyclic-nucleotide 3'-phosphodiesterase	3.1.4.37	0.457
3exh	TPP	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	1.2.4.1	0.457
3exh	TPP	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	1.2.4.1	0.457
4eyw	L0R	Carnitine O-palmitoyltransferase 2, mitochondrial	2.3.1.21	0.456
1yun	ATP	Probable nicotinate-nucleotide adenylyltransferase	2.7.7.18	0.455
2eeq	SAH	Diphthine synthase	/	0.454
4xvy	SAH	Mycinamicin III 3''-O-methyltransferase	2.1.1.237	0.454
2ycn	P61	Tyrosine phenol-lyase	4.1.99.2	0.453
3k8q	22A	Purine nucleoside phosphorylase	2.4.2.1	0.453
4i9i	1DY	Tankyrase-1	2.4.2.30	0.453
1q0r	AKT	Aclacinomycin methylesterase RdmC	3.1.1.95	0.452
4bb6	HD1	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.451
4bfv	ZVV	Pantothenate kinase	2.7.1.33	0.451
4bb5	HD2	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.450
2op0	7PC	Enoyl-ACP reductase	/	0.449
2pbz	ATP	Uncharacterized protein	/	0.449
3bi2	FAD	Polyamine oxidase FMS1	/	0.449
1rrm	APR	Lactaldehyde reductase	1.1.1.77	0.448
1sep	BIO	Sepiapterin reductase	1.1.1.153	0.448
3sn6	P0G	Beta-2 adrenergic receptor	/	0.448
1rsz	DIH	Purine nucleoside phosphorylase	2.4.2.1	0.447
2qim	ZEA	Class 10 plant pathogenesis-related protein	/	0.447
2zev	B71	Geranylgeranyl pyrophosphate synthase	/	0.447
3mde	CO8	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	1.3.8.7	0.447
4a8v	2AN	Major pollen allergen Bet v 1-J	/	0.447
4ihl	1F5	14-3-3 protein zeta/delta	/	0.447
1dfo	PLG	Serine hydroxymethyltransferase	2.1.2.1	0.446
1zw1	TN5	Enoyl-ACP reductase	/	0.446
3ozc	4CT	S-methyl-5'-thioadenosine phosphorylase	/	0.446
4k4e	K4E	Tankyrase-1	2.4.2.30	0.446
1mcz	RMN	Benzoylformate decarboxylase	4.1.1.7	0.445
1so2	666	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	3.1.4.17	0.445
2oci	TYC	Valacyclovir hydrolase	3.1	0.445
1kzj	CB3	Thymidylate synthase	/	0.444
1lnm	DTX	Bilin-binding protein	/	0.444
2a0w	DIH	Purine nucleoside phosphorylase	2.4.2.1	0.444
4epq	0RR	Poly(ADP-ribose) glycohydrolase	/	0.444
4gdp	FAD	Polyamine oxidase FMS1	/	0.444
1t7o	152	Carnitine O-acetyltransferase	2.3.1.7	0.443
1trg	CB3	Thymidylate synthase	/	0.443
2dsh	SAH	Diphthine synthase	/	0.443
2o2y	TCL	Enoyl-ACP reductase	/	0.443
3jpu	TY4	Transcriptional activator protein LasR	/	0.443
4ly9	1YY	Glucokinase regulatory protein	/	0.443
4xzj	NAD	Putative NAD(+)--arginine ADP-ribosyltransferase Vis	2.4.2.31	0.443
1kt8	ILP	Branched-chain-amino-acid aminotransferase, mitochondrial	2.6.1.42	0.442
1pq9	44B	Oxysterols receptor LXR-beta	/	0.442
3ch6	311	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.442
3exn	ACO	Probable acetyltransferase	/	0.442
3jq6	DX1	Pteridine reductase, putative	/	0.442
5bt4	2LO	Bromodomain-containing protein 4	/	0.442
1qoq	IGP	Tryptophan synthase alpha chain	/	0.441
1y2e	5DE	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.441
3bi5	FAD	Polyamine oxidase FMS1	/	0.441
3biy	01K	Histone acetyltransferase p300	/	0.441
4bj9	UHB	Tankyrase-2	2.4.2.30	0.441
4li8	1XQ	Tankyrase-1	2.4.2.30	0.441
2f3r	G5P	Guanylate kinase	2.7.4.8	0.440
2pnc	CLU	Primary amine oxidase, liver isozyme	/	0.440