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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4aguD15Cyclin-dependent kinase-like 1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4aguD15Cyclin-dependent kinase-like 1/1.000
3my5RFZCyclin-dependent kinase 22.7.11.220.494
4bcmT7ZCyclin-dependent kinase 22.7.11.220.492
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.491
3at4CCKCasein kinase II subunit alpha2.7.11.10.489
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.488
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.487
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.483
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.480
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.480
3i60E86Mitogen-activated protein kinase 12.7.11.240.479
1pjkANPCasein kinase II subunit alpha2.7.11.10.475
2vu3LZECyclin-dependent kinase 22.7.11.220.474
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.474
4grb0XGCasein kinase II subunit alpha2.7.11.10.473
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.472
4fv9E71Mitogen-activated protein kinase 12.7.11.240.472
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.471
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.470
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.469
4o0wADNAurora kinase A2.7.11.10.469
3axwTIDCasein kinase II subunit alpha2.7.11.10.468
3js2VM1Fibroblast growth factor receptor 1/0.467
4ijp1EHSerine/threonine-protein kinase PRP4 homolog2.7.11.10.467
3q9xEMOCasein kinase II subunit alpha2.7.11.10.463
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.463
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.462
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.461
2pvlP55Casein kinase II subunit alpha2.7.11.10.459
3bqr4RBDeath-associated protein kinase 3/0.459
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.458
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.458
1fvv107Cyclin-dependent kinase 22.7.11.220.457
3pe2E1BCasein kinase II subunit alpha2.7.11.10.457
4btjATPTau-tubulin kinase 12.7.11.10.456
5cvfATPCasein kinase II subunit alpha2.7.11.10.456
2yaaATPDeath-associated protein kinase 2/0.455
3be9P04Casein kinase II subunit alpha2.7.11.10.455
3lltANPProtein serine/threonine kinase-1/0.455
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.454
4l9i8PRRhodopsin kinase/0.453
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.452
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.452
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.450
3c4xATPRhodopsin kinase/0.450
3nux3NVCyclin-dependent kinase 62.7.11.220.450
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.450
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.450
4j99ACPFibroblast growth factor receptor 2/0.450
4jajXU1Aurora kinase A2.7.11.10.450
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.450
5av3KMPDeath-associated protein kinase 12.7.11.10.450
2fvdLIACyclin-dependent kinase 22.7.11.220.449
4dgmAGICasein kinase II subunit alpha2.7.11.10.449
4f081RSTyrosine-protein kinase JAK2/0.449
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.449
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.447
4jia1K3Tyrosine-protein kinase JAK2/0.447
4qnyANPMitogen activated protein kinase, putative/0.447
5av2KMPDeath-associated protein kinase 12.7.11.10.447
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.446
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.446
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.445
2j0lANPFocal adhesion kinase 12.7.10.20.444
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.444
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.444
2x9fX9FEphrin type-B receptor 42.7.10.10.444
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3lpbNVBTyrosine-protein kinase JAK2/0.444
3rak03ZCyclin-dependent kinase 22.7.11.220.444
4c3pACPAurora kinase A2.7.11.10.444
4fv6E57Mitogen-activated protein kinase 12.7.11.240.444
1jklANPDeath-associated protein kinase 12.7.11.10.443
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.443
4aqc88ATyrosine-protein kinase JAK2/0.443
5dosATPAurora kinase A2.7.11.10.443
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.442
2ojj82AMitogen-activated protein kinase 12.7.11.240.442
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.441
4qmlANPSerine/threonine-protein kinase 242.7.11.10.440