Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3vs4VSFTyrosine-protein kinase HCK2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3vs4VSFTyrosine-protein kinase HCK2.7.10.21.000
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.675
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.632
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.631
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.607
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.605
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.604
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.602
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.599
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.596
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.589
3vryB43Tyrosine-protein kinase HCK2.7.10.20.585
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.578
4i22IREEpidermal growth factor receptor2.7.10.10.564
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.561
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.559
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.552
3vs1VSATyrosine-protein kinase HCK2.7.10.20.552
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.551
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.549
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.546
4hjoAQ4Epidermal growth factor receptor2.7.10.10.541
4y93746Tyrosine-protein kinase/0.541
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.533
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.531
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.530
4id71G0Activated CDC42 kinase 1/0.525
1bygSTUTyrosine-protein kinase CSK/0.524
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.524
2wotZZGTGF-beta receptor type-12.7.11.300.521
2gs7ANPEpidermal growth factor receptor2.7.10.10.520
4nka2K7Fibroblast growth factor receptor 1/0.518
4y95746Tyrosine-protein kinase/0.517
4yuqKS1Calmodulin-like domain protein kinase/0.517
4gk2L66Ephrin type-A receptor 32.7.10.10.515
2hk51BMTyrosine-protein kinase HCK2.7.10.20.514
3w2sW2REpidermal growth factor receptor2.7.10.10.513
4riyADPEpidermal growth factor receptor2.7.10.10.513
1u54ACPActivated CDC42 kinase 1/0.509
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.508
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.506
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.504
5e8wSTUTGF-beta receptor type-12.7.11.300.504
2of4979Tyrosine-protein kinase Lck2.7.10.20.503
3poz03PEpidermal growth factor receptor2.7.10.10.503
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.503
3l8p0CEAngiopoietin-1 receptor2.7.10.10.502
4gmy0X5Tyrosine-protein kinase JAK2/0.501
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.500
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.500
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.499
4zseANPEpidermal growth factor receptor2.7.10.10.499
5e8xSTUTGF-beta receptor type-12.7.11.300.499
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.498
2y6o1N1Ephrin type-A receptor 42.7.10.10.497
2of2547Tyrosine-protein kinase Lck2.7.10.20.495
1u4dDBQActivated CDC42 kinase 1/0.494
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.493
2vwx7X4Ephrin type-B receptor 42.7.10.10.492
4lggVGGProto-oncogene tyrosine-protein kinase Src2.7.10.20.492
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.491
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.491
3gxlQIGTGF-beta receptor type-12.7.11.300.490
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.489
3vjoANPEpidermal growth factor receptor2.7.10.10.489
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.488
4hvh19RTyrosine-protein kinase JAK32.7.10.20.486
4bb432WEphrin type-B receptor 42.7.10.10.485
4kiq1RAMitogen-activated protein kinase 14/0.485
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.485
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.485
1rw8580TGF-beta receptor type-12.7.11.300.484
2qo9ANPEphrin type-A receptor 32.7.10.10.484
3dtcVINMitogen-activated protein kinase kinase kinase 92.7.11.250.484
4j97ACPFibroblast growth factor receptor 2/0.484
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.484
2itnANPEpidermal growth factor receptor2.7.10.10.483
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.483
5aaaVGHALK tyrosine kinase receptor2.7.10.10.483
2balPQAMitogen-activated protein kinase 14/0.482
3a60STURibosomal protein S6 kinase beta-12.7.11.10.482
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.482
3ac1KZITyrosine-protein kinase Lck2.7.10.20.481
4gk3L87Ephrin type-A receptor 32.7.10.10.481
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.481
2c6eHPMAurora kinase A2.7.11.10.480
2ittAEEEpidermal growth factor receptor2.7.10.10.480
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.480
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.480
4mxaBK7Calmodulin-like domain protein kinase isoenzyme gamma, related/0.479
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.478
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.478
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.477
1xkkFMMEpidermal growth factor receptor2.7.10.10.477
2vx07X7Ephrin type-B receptor 42.7.10.10.477
2vx17X8Ephrin type-B receptor 42.7.10.10.477
4fob0USALK tyrosine kinase receptor2.7.10.10.477
2py3ACPFibroblast growth factor receptor 2/0.476
3ac2KSETyrosine-protein kinase Lck2.7.10.20.476
4g2fC07Ephrin type-A receptor 32.7.10.10.476
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.475
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.474
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.474
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.474
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.474
2vww7X2Ephrin type-B receptor 42.7.10.10.473
4erwSTUCyclin-dependent kinase 22.7.11.220.473
3ttjJBIMitogen-activated protein kinase 102.7.11.240.472
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.10.472
4nk92K5Fibroblast growth factor receptor 1/0.472
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.471
2qocANPEphrin type-A receptor 32.7.10.10.471
3gubGUBDeath-associated protein kinase 12.7.11.10.471
2qoqANPEphrin type-A receptor 32.7.10.10.470
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.470
4gk4L90Ephrin type-A receptor 32.7.10.10.470
2vwz7X6Ephrin type-B receptor 42.7.10.10.469
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.468
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.468
4nks2M2Fibroblast growth factor receptor 1/0.468
2vwy7X5Ephrin type-B receptor 42.7.10.10.467
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.467
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.467
4kip1R9Mitogen-activated protein kinase 14/0.467
2vwu7X1Ephrin type-B receptor 42.7.10.10.466
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.466
4c02TAKActivin receptor type-12.7.11.300.466
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.465
4i231C9Epidermal growth factor receptor2.7.10.10.465
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.464
2pwlACPFibroblast growth factor receptor 2/0.464
2pzpACPFibroblast growth factor receptor 2/0.464
3uvqFS8Mitogen-activated protein kinase 14/0.464
4c4g7RODual specificity protein kinase TTK2.7.12.10.464
2itvANPEpidermal growth factor receptor2.7.10.10.463
3oom507Activin receptor type-12.7.11.300.463
3w18N13Aurora kinase A2.7.11.10.463
4tuvCPZCytochrome P450 1191.140.463
1m75CAAHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.462
2henADPEphrin type-B receptor 22.7.10.10.462
3icrCOACoenzyme A disulfide reductase/0.462
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.462
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.461
2eb3ANPEpidermal growth factor receptor2.7.10.10.461
3h0sB38Acetyl-CoA carboxylase/0.461
3k5uPFQAurora kinase A2.7.11.10.461
3oriAGSSerine/threonine protein kinase/0.461
1u5rATPSerine/threonine-protein kinase TAO22.7.11.10.460
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.460
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.460
3zewSTUEphrin type-B receptor 42.7.10.10.460
4aotGW8Serine/threonine-protein kinase 102.7.11.10.460
1pn3TYDdTDP-epi-vancosaminyltransferase2.4.1.3110.459
2xp2VGHALK tyrosine kinase receptor2.7.10.10.459
3mtfA3FActivin receptor type-12.7.11.300.459
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.459
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.459
3q5iANPProtein kinase, putative/0.458
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.458
4qnaX11Serine/threonine-protein kinase 242.7.11.10.458
1osvCHCBile acid receptor/0.457
1pmeSB2Mitogen-activated protein kinase 12.7.11.240.457
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.457
3gc9B45Mitogen-activated protein kinase 112.7.11.240.457
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.457
4iebANPCalmodulin-domain protein kinase 1/0.457
3igoANPCalmodulin-domain protein kinase 1, putative/0.456
3s4qNK0Mitogen-activated protein kinase 14/0.456
4c4h7RODual specificity protein kinase TTK2.7.12.10.456
1gih1PUCyclin-dependent kinase 22.7.11.220.455
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.455
2itqITQEpidermal growth factor receptor2.7.10.10.455
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.455
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.455
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.455
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.455
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.455
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.455
1ir3ANPInsulin receptor2.7.10.10.454
1jpaANPEphrin type-B receptor 22.7.10.10.454
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.454
3a7hATPSerine/threonine-protein kinase 242.7.11.10.454
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.454
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.454
4kuhCAA3-hydroxybutyryl-CoA dehydrogenase/0.454
1dhjMTXDihydrofolate reductase1.5.1.30.453
2f4jVX6Tyrosine-protein kinase ABL12.7.10.20.453
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.453
2xikJ60Serine/threonine-protein kinase 252.7.11.10.453
3ormAGSSerine/threonine protein kinase/0.453
4f630S7Fibroblast growth factor receptor 1/0.453
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.453
4z34ON7Lysophosphatidic acid receptor 1/0.453
1dkfBMSRetinoic acid receptor alpha/0.452
2excJNKMitogen-activated protein kinase 102.7.11.240.452
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.452
4e4m0NHTyrosine-protein kinase JAK2/0.452
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.452
2yaaATPDeath-associated protein kinase 2/0.451
3el7PD3Proto-oncogene tyrosine-protein kinase Src2.7.10.20.451
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.260.451
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.451
4fod0UVALK tyrosine kinase receptor2.7.10.10.451
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.451
4wkqIREEpidermal growth factor receptor2.7.10.10.451
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.450
2g2fAGSTyrosine-protein kinase ABL12.7.10.20.450
2o0uC0MMitogen-activated protein kinase 102.7.11.240.450
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.450
2xa4AZ5Tyrosine-protein kinase JAK2/0.450
2zybKSLTyrosine-protein kinase Lck2.7.10.20.450
3acjKSSTyrosine-protein kinase Lck2.7.10.20.450
3aidARQGag-Pol polyprotein3.4.23.160.450
3inxJZCHeat shock protein HSP 90-alpha/0.450
4c62XWWTyrosine-protein kinase JAK2/0.450
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.449
2i1m5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.449
2x9fX9FEphrin type-B receptor 42.7.10.10.449
2xyuQ9GEphrin type-A receptor 42.7.10.10.449
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.449
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.449
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.449
1sguMK1Gag-Pol polyprotein3.4.23.160.448
3iw4LW4Protein kinase C alpha type2.7.11.130.448
4j16NADNAD/NADP transhydrogenase alpha subunit 1/0.448
4oj4DIFPeroxisome proliferator-activated receptor gamma/0.448
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.447
3ictCOACoenzyme A disulfide reductase/0.447
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.447
4bb3KKAIsopenicillin N synthase1.21.3.10.447
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.447
4wa9AXITyrosine-protein kinase ABL12.7.10.20.447
2c475IDCasein kinase I isoform gamma-2/0.446
3r9dX6BCyclin-dependent kinase 22.7.11.220.446
3upjU03Gag-Pol polyprotein/0.446
4a6bQG8Gag-Pol polyprotein3.4.23.160.446
4anqVGHALK tyrosine kinase receptor2.7.10.10.446
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.446
4ih8B43Calmodulin-domain protein kinase 1/0.446
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.446
1iyzNDPProbable quinone oxidoreductase/0.445
2aazCB3Thymidylate synthase2.1.1.450.445
2j0lANPFocal adhesion kinase 12.7.10.20.445
2yn8STUEphrin type-B receptor 42.7.10.10.445
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.445
3qlrNDPDihydrofolate reductase1.5.1.30.445
4ansVGHALK tyrosine kinase receptor2.7.10.10.445
2x3nFADProbable FAD-dependent monooxygenase/0.444
3aoxEMHALK tyrosine kinase receptor2.7.10.10.444
3hx4ANPCalmodulin-domain protein kinase 1/0.444
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.444
3r9hZ67Cyclin-dependent kinase 22.7.11.220.444
4a9tA9TSerine/threonine-protein kinase Chk22.7.11.10.444
4aa5NQBMitogen-activated protein kinase 14/0.444
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
4g1wG1WMitogen-activated protein kinase 82.7.11.240.444
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.444
4lopSB4Mitogen-activated protein kinase 14/0.444
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.444
1ie4T44Transthyretin/0.443
3t113T1Gag-Pol polyprotein3.4.23.160.443
4cd0AWJALK tyrosine kinase receptor2.7.10.10.443
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.443
1w06W05Isopenicillin N synthase1.21.3.10.442
2om9AJAPeroxisome proliferator-activated receptor gamma/0.442
2pz5ACPFibroblast growth factor receptor 2/0.442
2wqeADPAurora kinase A2.7.11.10.442
3mg3ECHOrange carotenoid-binding protein/0.442
3mwuBK3Calmodulin-domain protein kinase 1, putative/0.442
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.442
3w2rW2REpidermal growth factor receptor2.7.10.10.442
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.442
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.442
4qmpDKISerine/threonine-protein kinase 242.7.11.10.442
4y8wSTRSteroid 21-hydroxylase/0.442
5aacVGHALK tyrosine kinase receptor2.7.10.10.442
1fwkADPHomoserine kinase2.7.1.390.441
2ykbYKBHeat shock protein HSP 90-alpha/0.441
2ykjYKJHeat shock protein HSP 90-alpha/0.441
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.441
3hl7I47Mitogen-activated protein kinase 14/0.441
4aguD15Cyclin-dependent kinase-like 1/0.441
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
5auuLU2Death-associated protein kinase 12.7.11.10.441
1l3iSAHProbable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating)/0.440
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.440
2znq401Peroxisome proliferator-activated receptor delta/0.440
3fklFKLMitogen-activated protein kinase 14/0.440
4dfrMTXDihydrofolate reductase1.5.1.30.440
4nj32KDCyclin-dependent kinase 22.7.11.220.440
4wq4ATPtRNA N6-adenosine threonylcarbamoyltransferase/0.440
3uzcT4EAdenosine receptor A2a/0.440