sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3rzp | PRF | NADPH-dependent 7-cyano-7-deazaguanine reductase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3rzp | PRF | NADPH-dependent 7-cyano-7-deazaguanine reductase | / | 1.000 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.545 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.484 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.481 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.481 | |
| 1h65 | GDP | Translocase of chloroplast 34 | 3.6.5 | 0.474 | |
| 3uxv | GUN | NADPH-dependent 7-cyano-7-deazaguanine reductase | / | 0.467 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.465 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.463 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.463 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.461 | |
| 1cju | FOK | Adenylate cyclase type 2 | / | 0.460 | |
| 1cju | FOK | Adenylate cyclase type 5 | / | 0.460 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.459 | |
| 3ime | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.459 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.455 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.453 | |
| 4f70 | 0ST | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.452 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.451 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.450 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.450 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 4zwp | M44 | Xaa-Pro dipeptidase | 3.4.13.9 | 0.449 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.448 | |
| 4k0z | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.448 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.447 | |
| 2cft | PLP | Pyridoxal phosphate phosphatase | / | 0.447 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.446 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.446 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 5l3d | FAD | Lysine-specific histone demethylase 1A | 1 | 0.446 | |
| 1rdw | LAR | Actin, alpha skeletal muscle | / | 0.445 | |
| 2j2p | SC2 | Ficolin-2 | / | 0.445 | |
| 2nni | MTK | Cytochrome P450 2C8 | / | 0.445 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.445 | |
| 3wqt | ANP | Cell division protein FtsA | / | 0.445 | |
| 1omo | NAD | Alanine dehydrogenase | / | 0.444 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 1lrj | UD1 | UDP-glucose 4-epimerase | 5.1.3.2 | 0.443 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2a4x | BLM | Mitomycin-binding protein | / | 0.443 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.443 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.443 | |
| 4iah | 1DX | Alr2278 protein | / | 0.443 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.441 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.440 |