Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3lcjCOAPhosphopantetheine adenylyltransferase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3lcjCOAPhosphopantetheine adenylyltransferase/1.000
3rbaCODPhosphopantetheine adenylyltransferase/0.594
4nauAGSPhosphopantetheine adenylyltransferase/0.499
1esvLARActin, alpha skeletal muscle/0.486
1h6cNDPGlucose--fructose oxidoreductase1.1.99.280.485
5a0yCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.485
5a0yCOMMethyl-coenzyme M reductase I subunit beta2.8.4.10.485
1o9bNAIQuinate/shikimate dehydrogenase/0.482
3iocA5DPantothenate synthetase6.3.2.10.476
4fhd0TTSpore photoproduct lyase/0.473
1touB1VFatty acid-binding protein, adipocyte/0.472
1i59ANPChemotaxis protein CheA2.7.13.30.471
2r5nTPPTransketolase 1/0.471
3fr5I4AFatty acid-binding protein, adipocyte/0.470
2pidYSATyrosine--tRNA ligase, mitochondrial6.1.1.10.469
3apwDP0Alpha-1-acid glycoprotein 2/0.469
5kwvANPPantothenate synthetase/0.469
4fxy0W2Neurolysin, mitochondrial3.4.24.160.466
4u0sADPAdenosine monophosphate-protein transferase FICD2.7.7.n10.466
1evjNADGlucose--fructose oxidoreductase1.1.99.280.463
1jdzFMBPurine nucleoside phosphorylase/0.461
1towCRZFatty acid-binding protein, adipocyte/0.461
3e8xNAPBH1520 protein/0.461
3etdNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.460
3tjzGNPADP-ribosylation factor 1/0.460
1i59ADPChemotaxis protein CheA2.7.13.30.459
3qttANPPantothenate synthetase/0.457
1ci0FMNPyridoxamine 5'-phosphate oxidase1.4.3.50.456
1qruATPGlutamine--tRNA ligase6.1.1.180.456
1x27ASP_TYR_VAL_HIS_PTRTyrosine-protein kinase Lck2.7.10.20.456
3elbC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.455
4d04NAPPhenylacetone monooxygenase1.14.13.920.455
1nm5NAPNAD(P) transhydrogenase subunit beta1.6.1.20.454
2a9y26AAdenosine kinase2.7.1.200.454
3fr4F8AFatty acid-binding protein, adipocyte/0.454
4c77N01Phenylacetone monooxygenase1.14.13.920.454
4fm80UQBeta-secretase 13.4.23.460.454
4u0zAPCAdenosine monophosphate-protein transferase FICD2.7.7.n10.454
1vi2NADQuinate/shikimate dehydrogenase/0.453
4j0v1H7Beta-secretase 13.4.23.460.453
1vbmYSATyrosine--tRNA ligase6.1.1.10.452
1h6bNDPGlucose--fructose oxidoreductase1.1.99.280.451
4a99FADTetX family tetracycline inactivation enzyme/0.451
1rdwLARActin, alpha skeletal muscle/0.450
2oapANPType II secretion system protein (GspE-2)/0.450
3aezGDPPantothenate kinase2.7.1.330.450
3e6yCW114-3-3-like protein C/0.450
3qt62P0Mevalonate diphosphate decarboxylase/0.450
1jedADPSulfate adenylyltransferase/0.449
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.449
3lpiZ74Beta-secretase 13.4.23.460.449
4dan2FAPurine nucleoside phosphorylase DeoD-type2.4.2.10.449
1jil485Tyrosine--tRNA ligase/0.448
1rydNDPGlucose--fructose oxidoreductase1.1.99.280.448
1r6uTYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.447
3vx4ATPPutative ABC transporter, ATP-binding protein ComA/0.447
5hg0SAMPantothenate synthetase/0.447
2ea2F77Methionine aminopeptidase 2/0.446
2jlbUDMUncharacterized protein/0.446
2qw034Z4-chlorobenzoyl CoA ligase/0.446
2ylrNAPPhenylacetone monooxygenase1.14.13.920.446
3b1dPLSBetaC-S lyase/0.446
3p74FMNPentaerythritol tetranitrate reductase/0.446
4ba5PXGProbable aminotransferase/0.446
1euyQSIGlutamine--tRNA ligase6.1.1.180.445
1h6aNDPGlucose--fructose oxidoreductase1.1.99.280.445
1n1dC2GGlycerol-3-phosphate cytidylyltransferase2.7.7.390.445
1xjqADPBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 12.7.1.250.445
2f3rG5PGuanylate kinase2.7.4.80.445
3opxU5PSuppressor of disruption of TFIIS/0.445
4qbgAP5Adenylate kinase/0.445
3hk1B64Fatty acid-binding protein, adipocyte/0.444
3kjiADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.444
3nd6ATPPhosphopantetheine adenylyltransferase/0.444
4a6nFADTetX family tetracycline inactivation enzyme/0.444
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.444
1a5bIGPTryptophan synthase alpha chain/0.443
1pnqNDPNAD(P) transhydrogenase subunit beta1.6.1.20.443
2bb3SAHCobalamin biosynthesis precorrin-6Y methylase (CbiE)/0.443
2bn4NAPNADPH--cytochrome P450 reductase/0.443
3f03FMNPentaerythritol tetranitrate reductase/0.443
3i0pNADMalate dehydrogenase, putative/0.443
4fduIHSPutative multiple inositol polyphosphate histidine phosphatase 1/0.443
4gukP2GNeuronal calcium sensor 1/0.443
4hmsFMNPhenazine biosynthesis protein PhzG1.40.443
4hn1TYDdTDP-4-dehydro-6-deoxyglucose 3-epimerase5.1.3.270.443
1jdvADNPurine nucleoside phosphorylase/0.442
3lnc5GPGuanylate kinase/0.442
4yj2GTPTubulin alpha-1B chain/0.442
1b2lNDCAlcohol dehydrogenase1.1.1.10.441
1xddAAYIntegrin alpha-L/0.441
3gegNADShort-chain dehydrogenase/reductase SDR/0.441
4i6gFADCryptochrome-2/0.441
4ts9FMCPurine nucleoside phosphorylase DeoD-type/0.441
4zj8SUVOrexin receptor type 1/0.441
2aa3AP0L-lactate dehydrogenase/0.440
2dzbHH2Dihydropteroate synthase/0.440
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.440
3c8aARG_ARG_GLY_LEU_NH2Botulinum neurotoxin type A3.4.24.690.440
3fun798Leukotriene A-4 hydrolase3.3.2.60.440
3jypNADQuinate/shikimate dehydrogenase (NAD(+))/0.440
3m2uCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.440
3vr8RQXSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial/0.440
3vr8RQXCytochrome b-large subunit/0.440
4dptAGSMevalonate diphosphate decarboxylase/0.440