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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3hllI45Mitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3hllI45Mitogen-activated protein kinase 14/1.000
4lopSB4Mitogen-activated protein kinase 14/0.561
3roc29AMitogen-activated protein kinase 14/0.543
3fklFKLMitogen-activated protein kinase 14/0.530
3mvl38PMitogen-activated protein kinase 14/0.523
3hl7I47Mitogen-activated protein kinase 14/0.522
3kf7L9GMitogen-activated protein kinase 14/0.521
4aacAAVMitogen-activated protein kinase 14/0.520
1yw2PGJMitogen-activated protein kinase 14/0.508
3gu83GUDeath-associated protein kinase 12.7.11.10.506
3dt1P40Mitogen-activated protein kinase 14/0.500
3iphG11Mitogen-activated protein kinase 14/0.500
4nk92K5Fibroblast growth factor receptor 1/0.498
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.491
3fmh533Mitogen-activated protein kinase 14/0.488
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.488
1ouk084Mitogen-activated protein kinase 14/0.487
3fln3FNMitogen-activated protein kinase 14/0.487
1zz2B11Mitogen-activated protein kinase 14/0.486
3flyFLYMitogen-activated protein kinase 14/0.486
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.485
2znq401Peroxisome proliferator-activated receptor delta/0.484
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.484
3hx4ANPCalmodulin-domain protein kinase 1/0.483
3nww3NWMitogen-activated protein kinase 14/0.482
3s4qNK0Mitogen-activated protein kinase 14/0.482
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.480
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.479
2q59240Peroxisome proliferator-activated receptor gamma/0.478
2ghlLIBMitogen-activated protein kinase 14/0.477
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.477
4kip1R9Mitogen-activated protein kinase 14/0.477
4loqSB4Mitogen-activated protein kinase 14/0.477
2znnS44Peroxisome proliferator-activated receptor alpha/0.474
3gc9B45Mitogen-activated protein kinase 112.7.11.240.474
4kiq1RAMitogen-activated protein kinase 14/0.474
1nvtNAPShikimate dehydrogenase (NADP(+))/0.473
4ubsDIFPentalenic acid synthase1.14.15.110.473
1rfuADPPyridoxal kinase2.7.1.350.472
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.472
2qd9LGFMitogen-activated protein kinase 14/0.471
4ic7ANPMitogen-activated protein kinase 72.7.11.240.471
1y0s331Peroxisome proliferator-activated receptor delta/0.470
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.470
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.470
3oafOAGDihydrofolate reductase1.5.1.30.468
3ttiKBIMitogen-activated protein kinase 102.7.11.240.468
3gubGUBDeath-associated protein kinase 12.7.11.10.467
1ywrLI9Mitogen-activated protein kinase 14/0.466
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.466
1eupASD6-deoxyerythronolide B hydroxylase/0.465
3d84NDPDihydrofolate reductase1.5.1.30.465
4a6nFADTetX family tetracycline inactivation enzyme/0.465
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.465
2balPQAMitogen-activated protein kinase 14/0.464
2p33J07Mitogen-activated protein kinase 102.7.11.240.464
3mpaSB2Mitogen-activated protein kinase 14/0.464
4oj4DIFPeroxisome proliferator-activated receptor gamma/0.464
1pmn984Mitogen-activated protein kinase 102.7.11.240.463
4aa5NQBMitogen-activated protein kinase 14/0.463
4cd2FOLDihydrofolate reductase1.5.1.30.463
4g95OAGDihydrofolate reductase1.5.1.30.463
4looSB4Mitogen-activated protein kinase 14/0.463
1jioDEB6-deoxyerythronolide B hydroxylase/0.462
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.462
3l9hEMQKinesin-like protein KIF11/0.462
3nxxNDPDihydrofolate reductase1.5.1.30.462
4a99FADTetX family tetracycline inactivation enzyme/0.462
4ewqMWLMitogen-activated protein kinase 14/0.462
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
5itzLOCTubulin beta-2B chain/0.462
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
4awp99AHeat shock protein HSP 90-alpha/0.461
1zyjBI5Mitogen-activated protein kinase 14/0.460
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.459
3fmkFMKMitogen-activated protein kinase 14/0.459
3sx2NADUncharacterized protein/0.459
3wmxNADNAD dependent epimerase/dehydratase/0.459
4h8nNDPNADPH-dependent conjugated polyketone reductase C2/0.459
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.458
3kpkFADSulfide-quinone reductase/0.458
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.458
1bwsNDPGDP-L-fucose synthase/0.457
1eh4IC1Casein kinase I homolog 12.7.11.10.457
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.457
4iv8SAMPhosphoethanolamine N-methyltransferase,putative/0.457
4njvRITProtease/0.457
1jipKTN6-deoxyerythronolide B hydroxylase/0.456
1k6cMK1Gag-Pol polyprotein3.4.23.160.456
1vjy460TGF-beta receptor type-12.7.11.300.456
1xkkFMMEpidermal growth factor receptor2.7.10.10.456
2cy0NAPShikimate dehydrogenase (NADP(+))/0.456
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.456
3ttjJBIMitogen-activated protein kinase 102.7.11.240.456
3zk5Z18Cytochrome P450 monooxygenase PikC/0.456
2o0uC0MMitogen-activated protein kinase 102.7.11.240.455
3fskRO6Mitogen-activated protein kinase 14/0.455
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.455
3zlyYSODual specificity mitogen-activated protein kinase kinase 12.7.12.20.455
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.455
2b1pAIZMitogen-activated protein kinase 102.7.11.240.454
4fob0USALK tyrosine kinase receptor2.7.10.10.454
4y93746Tyrosine-protein kinase/0.454
1k6tXN1Gag-Pol polyprotein3.4.23.160.453
1xe55FEPlasmepsin-23.4.23.390.453
3flzFLZMitogen-activated protein kinase 14/0.453
3sp9IL2Peroxisome proliferator-activated receptor delta/0.453
5e8xSTUTGF-beta receptor type-12.7.11.300.453
3fi4FI4Mitogen-activated protein kinase 14/0.452
4f650S9Fibroblast growth factor receptor 1/0.452
2ev9NAPShikimate dehydrogenase (NADP(+))/0.451
2x7hPFNProstaglandin reductase 310.451
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.451
3w33W19Epidermal growth factor receptor2.7.10.10.451
3zuyTCHTransporter/0.451
4c02TAKActivin receptor type-12.7.11.300.451
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.450
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.450
3tvuB37Acetyl-CoA carboxylase/0.450
4dfrMTXDihydrofolate reductase1.5.1.30.450
3d7kD7KBenzaldehyde lyase/0.449
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.449
3uibSB2Putative mitogen-activated protein kinase/0.449
4bgg844Activin receptor type-12.7.11.300.449
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.448
2b53D23Cyclin-dependent kinase 22.7.11.220.448
2hqpNDPDihydrofolate reductase1.5.1.30.448
2q61SF1Peroxisome proliferator-activated receptor gamma/0.448
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.448
3hvcGG5Mitogen-activated protein kinase 14/0.448
3lqfNADGalactitol dehydrogenase/0.448
3mtfA3FActivin receptor type-12.7.11.300.448
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.448
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.448
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.448
1dhjMTXDihydrofolate reductase1.5.1.30.447
1dr2TAPDihydrofolate reductase1.5.1.30.447
2nmtNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.447
2uxoTACHTH-type transcriptional regulator TtgR/0.447
2znoS44Peroxisome proliferator-activated receptor gamma/0.447
2znpK55Peroxisome proliferator-activated receptor delta/0.447
3fl4FL4Mitogen-activated protein kinase 14/0.447
3tm5SFGUncharacterized protein/0.447
3tqhNDPQuinone oxidoreductase/0.447
4eh60ONMitogen-activated protein kinase 14/0.447
4v12POGMaoC like domain protein/0.447
4xiwAZMCarbonic anhydrase, alpha type/0.447
1diuBDMDihydrofolate reductase1.5.1.30.446
2hfuMEVMevalonate kinase/0.446
3idsNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.446
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.446
3q43D66M1 family aminopeptidase3.4.110.446
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.446
1c6zROCProtease/0.445
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
2dvlFADAcyl-CoA dehydrogenase/0.445
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.445
4geb0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.445
4ipw1G7Mycocyclosin synthase1.14.21.90.445
4jx1CAMCamphor 5-monooxygenase1.14.15.10.445
4v010LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b/0.445
1iidNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.444
1zmcNADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.444
2ghmLICMitogen-activated protein kinase 14/0.444
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.444
2p4yC03Peroxisome proliferator-activated receptor gamma/0.444
2q9fC3SCholesterol 24-hydroxylase/0.444
4dgnLU2Casein kinase II subunit alpha2.7.11.10.444
4g170VNCasein kinase I isoform gamma-32.7.11.10.444
4nks2M2Fibroblast growth factor receptor 1/0.444
1rb3MTXDihydrofolate reductase1.5.1.30.443
2pwlACPFibroblast growth factor receptor 2/0.443
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.443
2y6o1N1Ephrin type-A receptor 42.7.10.10.443
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.443
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
3sheI85MAP kinase-activated protein kinase 32.7.11.10.443
3ukuC69Actin-related protein 3/0.443
3x2eNAIAdenosylhomocysteinase/0.443
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.443
1vbiNADMalate/L-lactate dehydrogenase family protein/0.442
1xl2189Gag-Pol polyprotein3.4.23.160.442
1zgyBRLPeroxisome proliferator-activated receptor gamma/0.442
2wedPP6Penicillopepsin-13.4.23.200.442
3fknFKNMitogen-activated protein kinase 14/0.442
3r3d4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.442
3r9uFADThioredoxin reductase/0.442
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.442
4i22IREEpidermal growth factor receptor2.7.10.10.442
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1dirNADDihydropteridine reductase1.5.1.340.441
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.441
1jpaANPEphrin type-B receptor 22.7.10.10.441
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1ove358Mitogen-activated protein kinase 14/0.441
1unlRRCCyclin-dependent-like kinase 52.7.11.10.441
1xddAAYIntegrin alpha-L/0.441
2c6hPXICytochrome P450 monooxygenase PikC/0.441
2gr1FADFerredoxin reductase/0.441
2xiyXIYSerine/threonine-protein kinase pim-12.7.11.10.441
4a31MYAGlycylpeptide N-tetradecanoyltransferase/0.441
4b7dQLECytochrome P450 monooxygenase PikC/0.441
4f630S7Fibroblast growth factor receptor 1/0.441
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.441
4gk2L66Ephrin type-A receptor 32.7.10.10.441
4ylfFADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog/0.441
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
1bxoPP7Penicillopepsin-13.4.23.200.440
1rfvADPPyridoxal kinase2.7.1.350.440
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.440
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.440
2y8qADP5'-AMP-activated protein kinase subunit gamma-1/0.440
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.440
3flsFLSMitogen-activated protein kinase 14/0.440
3koo24DBifunctional epoxide hydrolase 23.3.2.100.440
3l0lHC3Nuclear receptor ROR-gamma/0.440
3mwuBK3Calmodulin-domain protein kinase 1, putative/0.440
3r324CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.440
3t2zFADSulfide-quinone reductase/0.440
3tea4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.440
4awq592Heat shock protein HSP 90-alpha/0.440
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.440
4ele31IDihydrofolate reductase/0.440
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.440
4h50NAPBiphenyl dioxygenase ferredoxin reductase subunit/0.440
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.440
4ktkKTKCytochrome P450/0.440
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.440
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.440