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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3h4gFIDAlcohol dehydrogenase [NADP(+)]1.1.1.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3h4gFIDAlcohol dehydrogenase [NADP(+)]1.1.1.21.000
3cv7C2UAlcohol dehydrogenase [NADP(+)]1.1.1.20.547
2pd9FIDAldose reductase1.1.1.210.526
4gabFIDAldo-keto reductase family 1 member B101.1.10.524
2pdwFIDAldose reductase1.1.1.210.523
1pwmFIDAldose reductase1.1.1.210.513
2pdkSBIAldose reductase1.1.1.210.511
3u2cSUZAldose reductase1.1.1.210.510
2f2kTGGAldose reductase1.1.1.210.507
3s3gTLTAldose reductase1.1.1.210.501
3fx4FX4Alcohol dehydrogenase [NADP(+)]1.1.1.20.497
2is72CLAldose reductase1.1.1.210.496
3p2vDOYAldose reductase1.1.1.210.493
3v35NTIAldose reductase1.1.1.210.485
2iejS48Protein farnesyltransferase subunit beta2.5.1.580.484
1yw7A41Methionine aminopeptidase 2/0.482
2pdj393Aldose reductase1.1.1.210.479
2pdyFIDAldose reductase1.1.1.210.479
1ekoI84Aldose reductase1.1.1.210.477
5kf2ACOPredicted acetyltransferase/0.477
1dlrMXADihydrofolate reductase1.5.1.30.473
1ef3FIDAldose reductase1.1.1.210.472
2iqdLPAAldose reductase1.1.1.210.472
5liu388Aldo-keto reductase family 1 member B101.1.10.472
2vi5Y196,7-dimethyl-8-ribityllumazine synthase2.5.1.780.471
2ea4F79Methionine aminopeptidase 2/0.466
2fzbTOLAldose reductase1.1.1.210.466
1gt5BZQOdorant-binding protein/0.465
2agtFIDAldose reductase1.1.1.210.465
2inzOHPAldose reductase1.1.1.210.465
2nvcITAAldose reductase1.1.1.210.465
3f3y4OABile salt sulfotransferase2.8.2.140.464
1ah0SBIAldose reductase1.1.1.210.462
3rsv3RSBeta-secretase 13.4.23.460.462
3szfDCQSulfide-quinone reductase/0.462
2pdlTOLAldose reductase1.1.1.210.461
2r6kGTXGlutathione S-transferase A12.5.1.180.461
1yw9A84Methionine aminopeptidase 2/0.460
5kgjACOPredicted acetyltransferase/0.460
3v36NAPAldose reductase1.1.1.210.459
2poqISDTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase1.3.1.200.458
4lsaBLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.458
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.457
1lnmDTXBilin-binding protein/0.456
2ea2F77Methionine aminopeptidase 2/0.456
2pdiZSTAldose reductase1.1.1.210.456
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.456
3t0kDCQSulfide-quinone reductase/0.455
1pq944BOxysterols receptor LXR-beta/0.454
1pqc444Oxysterols receptor LXR-beta/0.454
2gmsP0PPutative pyridoxamine 5-phosphate-dependent dehydrase/0.452
5stdUNNScytalone dehydratase4.2.1.940.452
2ga2A19Methionine aminopeptidase 2/0.451
2ikj393Aldose reductase1.1.1.210.451
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.451
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
2pdh47DAldose reductase1.1.1.210.450
2r86ATP5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase/0.450
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
4wevSUZAldo-keto reductase family 1 member B101.1.10.450
4xzjNADPutative NAD(+)--arginine ADP-ribosyltransferase Vis2.4.2.310.450
1e6zNGOChitinase/0.449
1yw8A75Methionine aminopeptidase 2/0.449
2bjsACVIsopenicillin N synthase1.21.3.10.449
1zuaTOLAldo-keto reductase family 1 member B101.1.10.448
2pdmZSTAldose reductase1.1.1.210.448
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.448
1el3I84Aldose reductase1.1.1.210.447
1g63FMNEpidermin decarboxylase4.1.10.447
1ni4TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.447
1ni4TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.447
2pdfZSTAldose reductase1.1.1.210.447
3bloQEIQueuine tRNA-ribosyltransferase2.4.2.290.447
3dvaTPWPyruvate dehydrogenase E1 component subunit alpha1.2.4.10.447
3dvaTPWPyruvate dehydrogenase E1 component subunit beta1.2.4.10.447
1zq5E04Aldo-keto reductase family 1 member C3/0.446
2vrjNCWBeta-glucosidase A3.2.1.210.446
3rviRVIBeta-secretase 13.4.23.460.446
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
4jq2SUZAldo-keto reductase family 1 member C2/0.446
4jq4IMNAldo-keto reductase family 1 member C2/0.446
1el4CTZObelin/0.445
1p8dCO1Oxysterols receptor LXR-beta/0.445
2ipw2CLAldose reductase1.1.1.210.445
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
5kf9ACOPredicted acetyltransferase/0.445
3ghsLDTAldose reductase1.1.1.210.444
4lm4JPZcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
2qx7NAPEugenol synthase 11.1.1.3180.443
4g2yNI5cGMP-specific 3',5'-cyclic phosphodiesterase/0.443
1e2lTMCThymidine kinase/0.442
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
2o6hINI6,7-dimethyl-8-ribityllumazine synthase 12.5.1.780.442
2ovvPFHcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
3uph0C1Genome polyprotein2.7.7.480.442
4bfuZVUPantothenate kinase2.7.1.330.442
4jtrIBPAldo-keto reductase family 1 member C2/0.442
1qv0CZHObelin/0.441
3zv7NHGAcetylcholinesterase3.1.1.70.441
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
1az1ALRAldose reductase1.1.1.210.440
1az2NAPAldose reductase1.1.1.210.440
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
2acuNAPAldose reductase1.1.1.210.440
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.440
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
4jtrIZPAldo-keto reductase family 1 member C2/0.440