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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ghtLDTAldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3ghtLDTAldose reductase1.1.1.211.000
2i17LDTAldose reductase1.1.1.210.869
3ghsLDTAldose reductase1.1.1.210.863
3ghrLDTAldose reductase1.1.1.210.828
3ghuLDTAldose reductase1.1.1.210.815
3ld5LDTAldose reductase1.1.1.210.755
1us0LDTAldose reductase1.1.1.210.729
2qxwLDTAldose reductase1.1.1.210.719
2i16LDTAldose reductase1.1.1.210.718
2duxZSTAldose reductase1.1.1.210.703
3g5eQ74Aldose reductase1.1.1.210.683
2fz8ZSTAldose reductase1.1.1.210.682
2duzZSTAldose reductase1.1.1.210.677
2hvoZSTAldose reductase1.1.1.210.676
3mb9ZSTAldose reductase1.1.1.210.643
1pwlBFIAldose reductase1.1.1.210.637
1z3n3NAAldose reductase1.1.1.210.634
2pdlTOLAldose reductase1.1.1.210.632
2pdg47DAldose reductase1.1.1.210.623
2pzn393Aldose reductase1.1.1.210.621
2iki388Aldose reductase1.1.1.210.618
2hv5ZSTAldose reductase1.1.1.210.615
2pdh47DAldose reductase1.1.1.210.611
4yu153NAldose reductase1.1.1.210.597
3m64393Aldose reductase1.1.1.210.596
4gca2X9Aldose reductase1.1.1.210.595
1t40ID5Aldose reductase1.1.1.210.594
2pdp393Aldose reductase1.1.1.210.592
3mc5393Aldose reductase1.1.1.210.592
2pdn47DAldose reductase1.1.1.210.591
2pdfZSTAldose reductase1.1.1.210.590
2pdu393Aldose reductase1.1.1.210.586
3lz5LDTAldose reductase1.1.1.210.585
3lenZSTAldose reductase1.1.1.210.584
1z8962PAldose reductase1.1.1.210.583
2pdbZSTAldose reductase1.1.1.210.581
1ieiZESAldose reductase1.1.1.210.580
2pdq47DAldose reductase1.1.1.210.574
3m0iZSTAldose reductase1.1.1.210.574
2pdxZSTAldose reductase1.1.1.210.572
3t423T4Aldose reductase1.1.1.210.572
2dv0ZSTAldose reductase1.1.1.210.570
2pdj393Aldose reductase1.1.1.210.570
2pdc393Aldose reductase1.1.1.210.562
1frbZSTAldose reductase-related protein 2/0.556
2pd5ZSTAldose reductase1.1.1.210.556
2ikj393Aldose reductase1.1.1.210.549
1zuaTOLAldo-keto reductase family 1 member B101.1.10.548
2fz9ZSTAldose reductase1.1.1.210.548
1t41ID5Aldose reductase1.1.1.210.539
2iqdLPAAldose reductase1.1.1.210.529
3lqlLDTAldose reductase1.1.1.210.529
1ah3TOLAldose reductase1.1.1.210.526
3lboLDTAldose reductase1.1.1.210.526
2fzdTOLAldose reductase1.1.1.210.522
2ikhLITAldose reductase1.1.1.210.520
3m4h388Aldose reductase1.1.1.210.515
2pdwFIDAldose reductase1.1.1.210.506
2f2kTGGAldose reductase1.1.1.210.498
2fzbTOLAldose reductase1.1.1.210.494
2pd9FIDAldose reductase1.1.1.210.485
4dbw511Aldo-keto reductase family 1 member C3/0.483
2pdyFIDAldose reductase1.1.1.210.482
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.481
2agtFIDAldose reductase1.1.1.210.480
5liu388Aldo-keto reductase family 1 member B101.1.10.480
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.479
3c3xNAPEugenol synthase 11.1.1.3180.468
1gg5E09NAD(P)H dehydrogenase [quinone] 11.6.5.20.466
1x8lOXRRetinol dehydratase/0.466
4dz5NAPAldo-keto reductase family 1 member C3/0.466
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
4d2dALA_ALA_ALADi-or tripeptide:H+ symporter/0.465
1yw7A41Methionine aminopeptidase 2/0.464
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.463
4stdBFSScytalone dehydratase4.2.1.940.463
3f3y4OABile salt sulfotransferase2.8.2.140.462
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.462
3r8hZOMAldo-keto reductase family 1 member C3/0.461
2ea4F79Methionine aminopeptidase 2/0.459
2f3815MAldo-keto reductase family 1 member C3/0.459
2cekN8TAcetylcholinesterase3.1.1.70.458
3lz6A0DCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.457
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.456
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.456
3rj0BLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.456
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.456
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.456
1ry0PG2Aldo-keto reductase family 1 member C3/0.455
2ga2A19Methionine aminopeptidase 2/0.455
2qimZEAClass 10 plant pathogenesis-related protein/0.455
2v0mKLNCytochrome P450 3A4/0.455
3w2eFADNADH-cytochrome b5 reductase 31.6.2.20.455
1q83TZ5Acetylcholinesterase3.1.1.70.454
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.454
4u95MIYMultidrug efflux pump subunit AcrB/0.454
1ry8RUTAldo-keto reductase family 1 member C3/0.453
2c1zU2FAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.453
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.453
4lsaBLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.453
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
3r58NPSAldo-keto reductase family 1 member C3/0.452
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.452
4kn104JFolate receptor beta/0.452
4xwtU5PRibonuclease J/0.452
1ndzFR5Adenosine deaminase3.5.4.40.451
1yw9A84Methionine aminopeptidase 2/0.451
2ipiAKYAclacinomycin-N/aclacinomycin-A oxidase/0.451
1q84TZ4Acetylcholinesterase3.1.1.70.450
2xupTZ5Acetylcholinesterase3.1.1.70.450
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.450
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.450
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.450
4m6l21VDihydrofolate reductase1.5.1.30.450
5stdUNNScytalone dehydratase4.2.1.940.450
1e66HUXAcetylcholinesterase3.1.1.70.449
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.449
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
3ugrIMNAldo-keto reductase family 1 member C3/0.449
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.449
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.449
1jtqLY3Thymidylate synthase/0.448
3uzxAOX3-oxo-5-beta-steroid 4-dehydrogenase/0.448
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
1s07PLPAdenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.447
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.447
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.447
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.447
2ociTYCValacyclovir hydrolase3.10.447
3bxoUPPdTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose/0.447
3g1rFIT3-oxo-5-beta-steroid 4-dehydrogenase/0.447
3q9bB3NAcetylpolyamine amidohydrolase/0.447
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
2cbqTH2Neocarzinostatin/0.446
2xujTZ5Acetylcholinesterase3.1.1.70.446
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.446
4dbuBT9Aldo-keto reductase family 1 member C3/0.446
4htx19FcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.446
1ihiIU5Aldo-keto reductase family 1 member C2/0.445
1q23FUAChloramphenicol acetyltransferase2.3.1.280.445
2ckmAA7Acetylcholinesterase3.1.1.70.445
2y6fM9FIsopenicillin N synthase1.21.3.10.445
3c1oNAPEugenol synthase/0.445
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.445
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
4daj0HKMuscarinic acetylcholine receptor M3/0.445
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.444
1esmCOAPantothenate kinase2.7.1.330.444
3zv7NHGAcetylcholinesterase3.1.1.70.444
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
4m0f1YKAcetylcholinesterase3.1.1.70.444
2ycxP32Beta-1 adrenergic receptor/0.444
1lnmDTXBilin-binding protein/0.443
1r58AO5Methionine aminopeptidase 2/0.443
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.443
2vrjNCWBeta-glucosidase A3.2.1.210.443
3cgtBCDCyclomaltodextrin glucanotransferase2.4.1.190.443
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.443
4ea2RWZDehydrosqualene synthase/0.443
4u163C0Muscarinic acetylcholine receptor M3/0.443
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.442
1s36CEIObelin/0.442
2pdmZSTAldose reductase1.1.1.210.442
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.442
4kmzFOLFolate receptor beta/0.442
4xo7ASDAldo-keto reductase family 1 member C2/0.442
1obnASVIsopenicillin N synthase1.21.3.10.441
1ohkCOPDihydrofolate reductase1.5.1.30.441
1xu9CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.441
3jq8DX3Pteridine reductase, putative/0.441
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.441
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.441
4gm4TZDBenzoylformate decarboxylase4.1.1.70.441
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.440
4e0u0MVCyclic dipeptide N-prenyltransferase/0.440
4x7zZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.440