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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3gegNADShort-chain dehydrogenase/reductase SDR

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3gegNADShort-chain dehydrogenase/reductase SDR/1.000
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.568
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.555
1zemNADXylitol dehydrogenase/0.517
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.516
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.515
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.503
5jlaNADPutative short-chain dehydrogenase/reductase/0.497
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.496
4fn4NADShort chain dehydrogenase/0.495
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.493
3toxNAPPutative oxidoreductase/0.493
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.492
3lqfNADGalactitol dehydrogenase/0.490
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.490
1ipeNDPTropinone reductase 21.1.1.2360.488
1iy8NADLevodione reductase/0.488
1mgoNADAlcohol dehydrogenase E chain1.1.1.10.488
4qecNAPElxO/0.487
2ohxNADAlcohol dehydrogenase E chain1.1.1.10.486
1g1aNADdTDP-glucose 4,6-dehydratase/0.484
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.484
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.483
4cr8NADN-acylmannosamine 1-dehydrogenase1.1.1.2330.480
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.477
3r3sNADPutative oxidoreductase/0.477
1ae1NAPTropinone reductase 1/0.475
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.474
4hwkNAPSepiapterin reductase1.1.1.1530.474
1ldeNADAlcohol dehydrogenase E chain1.1.1.10.472
1qyvNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.471
5lc1NADL-threonine 3-dehydrogenase/0.471
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.470
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.468
3ak4NADNADH-dependent quinuclidinone reductase/0.467
4dwvNAJAlcohol dehydrogenase E chain1.1.1.10.467
4yagNAIC alpha-dehydrogenase/0.467
1axeNADAlcohol dehydrogenase E chain1.1.1.10.466
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.466
4esoNAPPutative oxidoreductase/0.466
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.466
4gllNADUDP-glucuronic acid decarboxylase 14.1.1.350.466
4j7xNAPSepiapterin reductase1.1.1.1530.466
4qedNAPElxO/0.466
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.464
4j7uNAPSepiapterin reductase1.1.1.1530.464
3d3wNAPL-xylulose reductase1.1.1.100.463
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.461
1kolNADGlutathione-independent formaldehyde dehydrogenase/0.460
1u3vNADAlcohol dehydrogenase 1B1.1.1.10.460
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.460
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.460
1tehNADAlcohol dehydrogenase class-31.1.1.10.459
2jahNDPClavaldehyde dehydrogenase/0.459
4bmvNAPShort-chain dehydrogenase/0.459
4ng5NAJAlcohol dehydrogenase E chain1.1.1.10.458
4b79NADProbable short-chain dehydrogenase/0.457
3ai3NDPNADPH-sorbose reductase/0.456
5cdsNAJAlcohol dehydrogenase E chain1.1.1.10.456
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.455
2yvwEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.455
3w8eNAD3-hydroxybutyrate dehydrogenase/0.455
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.455
4yaiNAIC alpha-dehydrogenase/0.455
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.453
3rj9NADAlcohol dehydrogenase1.1.1.10.453
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.452
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.452
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.452
3vdqNAD3-hydroxybutyrate dehydrogenase/0.452
1h2bNAJNAD-dependent alcohol dehydrogenase/0.451
1uayADNOxidoreductase/0.449
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
5idwNAPShort-chain dehydrogenase/reductase SDR/0.449
1f8fNADBenzyl alcohol dehydrogenase/0.448
4egbNADdTDP-glucose 4,6-dehydratase/0.448
4nd2A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.448
4nbwNADShort-chain dehydrogenase/reductase SDR/0.447
1xg5NAPDehydrogenase/reductase SDR family member 11/0.446
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.446
4nfsNAJAlcohol dehydrogenase E chain1.1.1.10.446
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.446
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.445
3ai2NDPNADPH-sorbose reductase/0.445
3jv7NADSecondary alcohol dehydrogenase/0.445
4nfhNAJAlcohol dehydrogenase E chain1.1.1.10.445
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.444
3p19NDPPutative blue fluorescent protein/0.444
1hldNADAlcohol dehydrogenase E chain1.1.1.10.443
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.443
1fduNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.442
1sowNADL-lactate dehydrogenase1.1.1.270.442
1mg5NAIAlcohol dehydrogenase1.1.1.10.441
3a1nNADNDP-sugar epimerase/0.441
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.441
3w8dNAD3-hydroxybutyrate dehydrogenase/0.441
2jkvNAP6-phosphogluconate dehydrogenase, decarboxylating1.1.1.440.440
3a4vNADNDP-sugar epimerase/0.440
3kjiADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.440
5kjfNAJAlcohol dehydrogenase E chain1.1.1.10.440