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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.11.000
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.512
2x1nX1NCyclin-dependent kinase 22.7.11.220.510
2uzeC95Cyclin-dependent kinase 22.7.11.220.499
1di8DTQCyclin-dependent kinase 22.7.11.220.495
2c5nCK8Cyclin-dependent kinase 22.7.11.220.493
3be9P04Casein kinase II subunit alpha2.7.11.10.493
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.491
1y91CT9Cyclin-dependent kinase 22.7.11.220.490
4ek610KCyclin-dependent kinase 22.7.11.220.487
2vagV25Dual specificity protein kinase CLK12.7.12.10.484
4wboANWRhodopsin kinase/0.484
1aq1STUCyclin-dependent kinase 22.7.11.220.482
2uzlC94Cyclin-dependent kinase 22.7.11.220.481
3rk507ZCyclin-dependent kinase 22.7.11.220.481
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.479
2pvnP63Casein kinase II subunit alpha2.7.11.10.478
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.476
1oitHDTCyclin-dependent kinase 22.7.11.220.474
2cchATPCyclin-dependent kinase 22.7.11.220.474
3rk708ZCyclin-dependent kinase 22.7.11.220.474
1h1r6CPCyclin-dependent kinase 22.7.11.220.472
3uli1N3Cyclin-dependent kinase 22.7.11.220.472
2bkzSBCCyclin-dependent kinase 22.7.11.220.471
3rmf20ZCyclin-dependent kinase 22.7.11.220.471
4fkv61KCyclin-dependent kinase 22.7.11.220.471
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
4i22IREEpidermal growth factor receptor2.7.10.10.470
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.469
2iw94SPCyclin-dependent kinase 22.7.11.220.468
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.468
2xikJ60Serine/threonine-protein kinase 252.7.11.10.468
3rni21ZCyclin-dependent kinase 22.7.11.220.468
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.468
1oirHDYCyclin-dependent kinase 22.7.11.220.467
3lfqA28Cyclin-dependent kinase 22.7.11.220.467
1xjdSTUProtein kinase C theta type2.7.11.130.466
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.466
1gih1PUCyclin-dependent kinase 22.7.11.220.465
1om1IQACasein kinase II subunit alpha2.7.11.10.465
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.465
1ke9LS5Cyclin-dependent kinase 22.7.11.220.464
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.464
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.464
3bhtMFRCyclin-dependent kinase 22.7.11.220.463
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.462
3sheI85MAP kinase-activated protein kinase 32.7.11.10.462
4dgo0JWCasein kinase II subunit alpha2.7.11.10.462
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.461
4jqeANPCasein kinase II subunit alpha2.7.11.10.461
1oiuN76Cyclin-dependent kinase 22.7.11.220.460
1t88CAMCamphor 5-monooxygenase1.14.15.10.460
2iw84SPCyclin-dependent kinase 22.7.11.220.460
2eufLQQCyclin-dependent kinase 62.7.11.220.458
3qtxX43Cyclin-dependent kinase 22.7.11.220.458
4acm7YGCyclin-dependent kinase 22.7.11.220.458
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.457
3gubGUBDeath-associated protein kinase 12.7.11.10.457
4anmWULCasein kinase II subunit alpha2.7.11.10.457
4bcpT3CCyclin-dependent kinase 22.7.11.220.457
4nj32KDCyclin-dependent kinase 22.7.11.220.457
3q43D66M1 family aminopeptidase3.4.110.456
1oiyN41Cyclin-dependent kinase 22.7.11.220.455
2btsU32Cyclin-dependent kinase 22.7.11.220.455
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.455
3c50ADPRhodopsin kinase/0.455
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.455
1eh4IC1Casein kinase I homolog 12.7.11.10.454
1h1s4SPCyclin-dependent kinase 22.7.11.220.454
1u4dDBQActivated CDC42 kinase 1/0.454
2xmyCDKCyclin-dependent kinase 22.7.11.220.454
3r9dX6BCyclin-dependent kinase 22.7.11.220.454
4dgnLU2Casein kinase II subunit alpha2.7.11.10.454
4fi1ATPCasein kinase II subunit alpha2.7.11.10.454
4fkr45KCyclin-dependent kinase 22.7.11.220.454
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.454
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.454
1oguST8Cyclin-dependent kinase 22.7.11.220.453
2c6tDT5Cyclin-dependent kinase 22.7.11.220.453
3ddpRC8Cyclin-dependent kinase 22.7.11.220.453
3r7iX9ICyclin-dependent kinase 22.7.11.220.453
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.453
2izsBRQCasein kinase I isoform gamma-32.7.11.10.452
3r9oZ71Cyclin-dependent kinase 22.7.11.220.452
2j9mPY8Cyclin-dependent kinase 22.7.11.220.451
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
4ek816KCyclin-dependent kinase 22.7.11.220.451
4g170VNCasein kinase I isoform gamma-32.7.11.10.451
2pvhP19Casein kinase II subunit alpha2.7.11.10.450
1m2pHNACasein kinase II subunit alpha2.7.11.10.449
1oi9N20Cyclin-dependent kinase 22.7.11.220.449
3qu0X40Cyclin-dependent kinase 22.7.11.220.449
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.449
4eoi1ROCyclin-dependent kinase 22.7.11.220.449
4erwSTUCyclin-dependent kinase 22.7.11.220.449
4fkj11KCyclin-dependent kinase 22.7.11.220.449
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.449
2yfeYFEPeroxisome proliferator-activated receptor gamma/0.448
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.448
3s1h56ZCyclin-dependent kinase 22.7.11.220.448
2c5yMTWCyclin-dependent kinase 22.7.11.220.447
4bcoT6QCyclin-dependent kinase 22.7.11.220.447
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.447
4nifANPMitogen-activated protein kinase 12.7.11.240.447
5cvhADPCasein kinase II subunit alpha2.7.11.10.447
1dm2HMDCyclin-dependent kinase 22.7.11.220.446
1g5sI17Cyclin-dependent kinase 22.7.11.220.446
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.446
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.446
2wihP48Cyclin-dependent kinase 22.7.11.220.446
3qtzX42Cyclin-dependent kinase 22.7.11.220.446
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.446
1e9hINRCyclin-dependent kinase 22.7.11.220.445
1ke6LS2Cyclin-dependent kinase 22.7.11.220.445
4bgg844Activin receptor type-12.7.11.300.445
4fks46KCyclin-dependent kinase 22.7.11.220.445
4req5ADMethylmalonyl-CoA mutase large subunit5.4.99.20.445
2uzbC75Cyclin-dependent kinase 22.7.11.220.444
3ddqRRCCyclin-dependent kinase 22.7.11.220.444
3nynSGVG protein-coupled receptor kinase 62.7.11.160.444
4fkg4CKCyclin-dependent kinase 22.7.11.220.444
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.444
4jr7GNPCasein kinase II subunit alpha2.7.11.10.444
1pxoCK7Cyclin-dependent kinase 22.7.11.220.443
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.443
3own3OWRenin3.4.23.150.443
3ral04ZCyclin-dependent kinase 22.7.11.220.443
4fkw62KCyclin-dependent kinase 22.7.11.220.443
1m2rMNYCasein kinase II subunit alpha2.7.11.10.442
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.442
2uzdC85Cyclin-dependent kinase 22.7.11.220.442
4eon1ROCyclin-dependent kinase 22.7.11.220.442
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.442
1pxlCK4Cyclin-dependent kinase 22.7.11.220.441
3rkb12ZCyclin-dependent kinase 22.7.11.220.441
3vt7VDXVitamin D3 receptor/0.441
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.441
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.441
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.441
5e8wSTUTGF-beta receptor type-12.7.11.300.441
1zys199Serine/threonine-protein kinase Chk12.7.11.10.440
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.440
2r3lSCWCyclin-dependent kinase 22.7.11.220.440
2uznC96Cyclin-dependent kinase 22.7.11.220.440
2vthLZ2Cyclin-dependent kinase 22.7.11.220.440
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.440
4fx360KCyclin-dependent kinase 22.7.11.220.440