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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2r3fSC8Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2r3fSC8Cyclin-dependent kinase 22.7.11.221.000
2r3p3SCCyclin-dependent kinase 22.7.11.220.670
2r3iSCFCyclin-dependent kinase 22.7.11.220.666
2r3q5SCCyclin-dependent kinase 22.7.11.220.656
2r3gSC9Cyclin-dependent kinase 22.7.11.220.633
2c6iDT1Cyclin-dependent kinase 22.7.11.220.632
3r83Z14Cyclin-dependent kinase 22.7.11.220.588
4fklCK2Cyclin-dependent kinase 22.7.11.220.588
3rahO1ZCyclin-dependent kinase 22.7.11.220.584
2r3r6SCCyclin-dependent kinase 22.7.11.220.555
2c69CT8Cyclin-dependent kinase 22.7.11.220.552
2r3o2SCCyclin-dependent kinase 22.7.11.220.552
1w8cN69Cyclin-dependent kinase 22.7.11.220.548
2exmZIPCyclin-dependent kinase 22.7.11.220.544
2r3kSCQCyclin-dependent kinase 22.7.11.220.542
3r7yZ04Cyclin-dependent kinase 22.7.11.220.542
3r9nZ68Cyclin-dependent kinase 22.7.11.220.537
4fkg4CKCyclin-dependent kinase 22.7.11.220.535
2btrU73Cyclin-dependent kinase 22.7.11.220.533
3iggEFQCyclin-dependent kinase 22.7.11.220.531
4fkt48KCyclin-dependent kinase 22.7.11.220.530
3rm719ZCyclin-dependent kinase 22.7.11.220.527
2r3mSCXCyclin-dependent kinase 22.7.11.220.526
2a0cCK9Cyclin-dependent kinase 22.7.11.220.522
3r1yX76Cyclin-dependent kinase 22.7.11.220.522
3lfsA07Cyclin-dependent kinase 22.7.11.220.521
1gz8MBPCyclin-dependent kinase 22.7.11.220.515
1y8yCT7Cyclin-dependent kinase 22.7.11.220.513
3qwjX6ACyclin-dependent kinase 22.7.11.220.512
4ek610KCyclin-dependent kinase 22.7.11.220.509
2r3jSCJCyclin-dependent kinase 22.7.11.220.508
1b38ATPCyclin-dependent kinase 22.7.11.220.507
3r7vZ02Cyclin-dependent kinase 22.7.11.220.507
3r8lZ30Cyclin-dependent kinase 22.7.11.220.507
3lfnA27Cyclin-dependent kinase 22.7.11.220.506
4fkq42KCyclin-dependent kinase 22.7.11.220.506
3lfqA28Cyclin-dependent kinase 22.7.11.220.505
2a4lRRCCyclin-dependent kinase 22.7.11.220.504
3wblPDYCyclin-dependent kinase 22.7.11.220.503
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.501
3qqlX03Cyclin-dependent kinase 22.7.11.220.501
4kd11QKCyclin-dependent kinase 22.7.11.220.501
2c6o4SPCyclin-dependent kinase 22.7.11.220.500
3raiX85Cyclin-dependent kinase 22.7.11.220.498
1b39ATPCyclin-dependent kinase 22.7.11.220.497
2c6lDT4Cyclin-dependent kinase 22.7.11.220.496
2c6kDT2Cyclin-dependent kinase 22.7.11.220.495
3qxoX65Cyclin-dependent kinase 22.7.11.220.495
1w0xOLOCyclin-dependent kinase 22.7.11.220.494
1pxoCK7Cyclin-dependent kinase 22.7.11.220.492
3qqhX0ACyclin-dependent kinase 22.7.11.220.491
3qtsX46Cyclin-dependent kinase 22.7.11.220.491
3r7uX96Cyclin-dependent kinase 22.7.11.220.490
4fkj11KCyclin-dependent kinase 22.7.11.220.490
1h0vUN4Cyclin-dependent kinase 22.7.11.220.489
3qzgX67Cyclin-dependent kinase 22.7.11.220.487
1oitHDTCyclin-dependent kinase 22.7.11.220.486
3r8vZ62Cyclin-dependent kinase 22.7.11.220.485
3ezvEZVCyclin-dependent kinase 22.7.11.220.484
3qzhX69Cyclin-dependent kinase 22.7.11.220.484
3r8uZ31Cyclin-dependent kinase 22.7.11.220.484
1ykr628Cyclin-dependent kinase 22.7.11.220.482
3rak03ZCyclin-dependent kinase 22.7.11.220.480
3qruX19Cyclin-dependent kinase 22.7.11.220.478
4fki09KCyclin-dependent kinase 22.7.11.220.478
3rm618ZCyclin-dependent kinase 22.7.11.220.477
2r3lSCWCyclin-dependent kinase 22.7.11.220.476
3qx2X63Cyclin-dependent kinase 22.7.11.220.475
3pxyJWSCyclin-dependent kinase 22.7.11.220.474
2uzoC62Cyclin-dependent kinase 22.7.11.220.473
3s2pPMUCyclin-dependent kinase 22.7.11.220.473
3sw719KCyclin-dependent kinase 22.7.11.220.473
1pxmCK5Cyclin-dependent kinase 22.7.11.220.472
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.472
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.471
3r28XA0Cyclin-dependent kinase 22.7.11.220.471
4fkr45KCyclin-dependent kinase 22.7.11.220.470
2j9mPY8Cyclin-dependent kinase 22.7.11.220.469
3s1h56ZCyclin-dependent kinase 22.7.11.220.469
4fkpLS5Cyclin-dependent kinase 22.7.11.220.467
3ezrEZRCyclin-dependent kinase 22.7.11.220.466
3ral04ZCyclin-dependent kinase 22.7.11.220.465
1h0w207Cyclin-dependent kinase 22.7.11.220.464
2uznC96Cyclin-dependent kinase 22.7.11.220.463
1ke5LS1Cyclin-dependent kinase 22.7.11.220.462
1pxpCK8Cyclin-dependent kinase 22.7.11.220.461
2c5yMTWCyclin-dependent kinase 22.7.11.220.460
2c68CT6Cyclin-dependent kinase 22.7.11.220.460
2b54D05Cyclin-dependent kinase 22.7.11.220.459
2c6mDT5Cyclin-dependent kinase 22.7.11.220.459
2vu3LZECyclin-dependent kinase 22.7.11.220.455
3qxpX64Cyclin-dependent kinase 22.7.11.220.455
2vttLZDCyclin-dependent kinase 22.7.11.220.454
1oirHDYCyclin-dependent kinase 22.7.11.220.453
3pj8404Cyclin-dependent kinase 22.7.11.220.453
3ig7EFPCyclin-dependent kinase 22.7.11.220.452
3my5RFZCyclin-dependent kinase 22.7.11.220.452
2btsU32Cyclin-dependent kinase 22.7.11.220.451
2vthLZ2Cyclin-dependent kinase 22.7.11.220.451
3rni21ZCyclin-dependent kinase 22.7.11.220.451
3fz1B98Cyclin-dependent kinase 22.7.11.220.450
3qziX72Cyclin-dependent kinase 22.7.11.220.450
4ek816KCyclin-dependent kinase 22.7.11.220.450
2fvdLIACyclin-dependent kinase 22.7.11.220.449
2w05FRTCyclin-dependent kinase 22.7.11.220.449
1gii1PUCyclin-dependent kinase 22.7.11.220.448
2vtsLZCCyclin-dependent kinase 22.7.11.220.448
5aniES4Cyclin-dependent kinase 22.7.11.220.448
2w06FRVCyclin-dependent kinase 22.7.11.220.447
3rpy27ZCyclin-dependent kinase 22.7.11.220.447
3r71X86Cyclin-dependent kinase 22.7.11.220.445
3rpv26ZCyclin-dependent kinase 22.7.11.220.445
4nj32KDCyclin-dependent kinase 22.7.11.220.445
2b53D23Cyclin-dependent kinase 22.7.11.220.443
3qqkX02Cyclin-dependent kinase 22.7.11.220.443
4bgh3I6Cyclin-dependent kinase 22.7.11.220.443
3r9hZ67Cyclin-dependent kinase 22.7.11.220.441