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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2j0lANPFocal adhesion kinase 12.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2j0lANPFocal adhesion kinase 12.7.10.21.000
4k8aK8AFocal adhesion kinase 12.7.10.20.519
2ijmATPFocal adhesion kinase 12.7.10.20.512
3c4xATPRhodopsin kinase/0.507
3c4zADPRhodopsin kinase/0.507
4jia1K3Tyrosine-protein kinase JAK2/0.507
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.498
4qmlANPSerine/threonine-protein kinase 242.7.11.10.496
2etm7PYFocal adhesion kinase 12.7.10.20.494
3c4wATPRhodopsin kinase/0.494
4l9i8PRRhodopsin kinase/0.494
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.493
2ijmADPFocal adhesion kinase 12.7.10.20.488
5av2KMPDeath-associated protein kinase 12.7.11.10.488
3zewSTUEphrin type-B receptor 42.7.10.10.484
5dosATPAurora kinase A2.7.11.10.482
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.479
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.477
4j95ACPFibroblast growth factor receptor 2/0.477
2henADPEphrin type-B receptor 22.7.10.10.476
2j0m4STFocal adhesion kinase 12.7.10.20.476
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.474
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.473
3bqr4RBDeath-associated protein kinase 3/0.472
3qc9ADPRhodopsin kinase/0.471
2qocANPEphrin type-A receptor 32.7.10.10.470
3t8oATPRhodopsin kinase/0.468
4c3pACPAurora kinase A2.7.11.10.468
2x9fX9FEphrin type-B receptor 42.7.10.10.467
3gu7ADPDeath-associated protein kinase 12.7.11.10.467
3nynSGVG protein-coupled receptor kinase 62.7.11.160.467
4ysjADPCalmodulin-like domain protein kinase/0.467
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.466
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.466
4j99ACPFibroblast growth factor receptor 2/0.466
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.463
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.462
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.461
2qo7ANPEphrin type-A receptor 32.7.10.10.461
2yaaATPDeath-associated protein kinase 2/0.459
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.458
3my5RFZCyclin-dependent kinase 22.7.11.220.458
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.458
1ig1ANPDeath-associated protein kinase 12.7.11.10.457
1jklANPDeath-associated protein kinase 12.7.11.10.456
2v7a627Tyrosine-protein kinase ABL12.7.10.20.456
2qoqANPEphrin type-A receptor 32.7.10.10.455
3js2VM1Fibroblast growth factor receptor 1/0.455
4deeADPAurora kinase A2.7.11.10.455
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.453
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.452
5av3KMPDeath-associated protein kinase 12.7.11.10.452
4gu94GUFocal adhesion kinase 12.7.10.20.450
2xvdAS6Ephrin type-B receptor 42.7.10.10.449
3pxkPXKFocal adhesion kinase 12.7.10.20.449
4o0uADNAurora kinase A2.7.11.10.449
4xlvACPInsulin receptor2.7.10.10.449
2w4jADPDeath-associated protein kinase 12.7.11.10.448
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.448
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.448
3lltANPProtein serine/threonine kinase-1/0.447
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.447
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.446
4gk4L90Ephrin type-A receptor 32.7.10.10.446
1jkkANPDeath-associated protein kinase 12.7.11.10.445
2hog710Serine/threonine-protein kinase Chk12.7.11.10.445
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.445
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
4qnyANPMitogen activated protein kinase, putative/0.445
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.444
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.444
3ztxZTXAurora kinase B-A2.7.11.10.443
4bcmT7ZCyclin-dependent kinase 22.7.11.220.443
4eooATPCyclin-dependent kinase 22.7.11.220.443
1finATPCyclin-dependent kinase 22.7.11.220.442
5dnrATPAurora kinase A2.7.11.10.442
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.441
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.440