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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2gfdRDAEndoplasmin

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2gfdRDAEndoplasmin/1.000
2fypRDEEndoplasmin/0.623
2gqpPA7Endoplasmin/0.575
1u2oNECEndoplasmin/0.568
1u0zRDCEndoplasmin/0.554
1qy5NECEndoplasmin/0.552
2hchN5AEndoplasmin/0.551
4fcr0TMHeat shock protein HSP 90-alpha/0.549
2werRDCATP-dependent molecular chaperone HSP82/0.547
2exlGDMEndoplasmin/0.539
1yszNECEndoplasmin/0.538
2hg1N5OEndoplasmin/0.536
1qy8RDIEndoplasmin/0.533
3rlq3RQHeat shock protein HSP 90-alpha/0.531
3ekrPY9Heat shock protein HSP 90-alpha/0.523
3ekoPYUHeat shock protein HSP 90-alpha/0.519
3c11GDMATP-dependent molecular chaperone HSP82/0.515
3hekBD0Heat shock protein HSP 90-alpha/0.515
2xd6XD6ATP-dependent molecular chaperone HSP82/0.511
4xc0ACPHeat shock cognate 90 kDa protein/0.509
3rlr3RRHeat shock protein HSP 90-alpha/0.508
2iwuNP5ATP-dependent molecular chaperone HSP82/0.504
2wi6ZZ6Heat shock protein HSP 90-alpha/0.503
3whaWHAHeat shock protein HSP 90-alpha/0.503
2vw5BC6ATP-dependent molecular chaperone HSP82/0.502
2byh2D7Heat shock protein HSP 90-alpha/0.501
3k99PFTHeat shock protein HSP 90-alpha/0.500
3hhu819Heat shock protein HSP 90-alpha/0.495
1byqADPHeat shock protein HSP 90-alpha/0.494
2bz5AB4Heat shock protein HSP 90-alpha/0.494
3k974CDHeat shock protein HSP 90-alpha/0.494
2yegXQGHeat shock protein HSP 90-alpha/0.493
2xx213CATP-dependent molecular chaperone HSP82/0.492
4bqjXKLHeat shock protein HSP 90-alpha/0.492
3r4pFU7Heat shock protein HSP 90-alpha/0.490
2xhrC0PHeat shock protein HSP 90-alpha/0.488
3hyz42CHeat shock protein HSP 90-alpha/0.488
3vhaVHAHeat shock protein HSP 90-alpha/0.488
1bgqRDCATP-dependent molecular chaperone HSP82/0.487
2breKJ2ATP-dependent molecular chaperone HSP82/0.486
3r4nFU5Heat shock protein HSP 90-alpha/0.486
1u0yPA7Endoplasmin/0.483
2bt0CT5Heat shock protein HSP 90-alpha/0.483
1yc14BCHeat shock protein HSP 90-alpha/0.482
2yefANPHeat shock protein HSP 90-alpha/0.481
3ft8MOJHeat shock protein HSP 90-alpha/0.481
2xabVHDHeat shock protein HSP 90-alpha/0.478
3pehIBDEndoplasmin homolog, putative/0.477
4gqtADPHeat shock protein 90/0.477
1y4sADPChaperone protein HtpG/0.476
3t2sAGSHeat shock protein HSP 90-alpha/0.475
2xhtC0YHeat shock protein HSP 90-alpha/0.474
4jqlVJ6Heat shock protein HSP 90-alpha/0.474
2wepADPATP-dependent molecular chaperone HSP82/0.473
3b28B2XHeat shock protein HSP 90-alpha/0.473
3t10ACPHeat shock protein HSP 90-alpha/0.473
2iwxM1SATP-dependent molecular chaperone HSP82/0.471
1yc34BCHeat shock protein HSP 90-alpha/0.470
3k981RCHeat shock protein HSP 90-alpha/0.469
2wi5ZZ5Heat shock protein HSP 90-alpha/0.467
4ce3L4VATP-dependent molecular chaperone HSP82/0.465
4asg814ATP-dependent molecular chaperone HSP82/0.463
2yi5YI5Heat shock protein HSP 90-alpha/0.462
1am1ADPATP-dependent molecular chaperone HSP82/0.458
4eftEFTHeat shock protein HSP 90-alpha/0.458
2byi2DDHeat shock protein HSP 90-alpha/0.457
2esaGDMEndoplasmin/0.457
2zdyADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.457
4ce17FKATP-dependent molecular chaperone HSP82/0.457
2brcCT5ATP-dependent molecular chaperone HSP82/0.456
2xcmADPCytosolic heat shock protein 90/0.456
1uy7PU4Heat shock protein HSP 90-alpha/0.455
3t1kANPHeat shock protein HSP 90-alpha/0.454
4bqg50QHeat shock protein HSP 90-alpha/0.454
4egkRDCHeat shock protein HSP 90-alpha/0.453
4xcjADPHeat shock cognate 90 kDa protein/0.453
2e0aANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.452
4tuvCPZCytochrome P450 1191.140.452
1yetGDMHeat shock protein HSP 90-alpha/0.451
3qdd94MHeat shock protein HSP 90-alpha/0.451
5f5rANPHeat shock protein 75 kDa, mitochondrial/0.451
1uy8PU5Heat shock protein HSP 90-alpha/0.450
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.450
4egh0OYHeat shock protein HSP 90-alpha/0.450
4xdmGDMHeat shock cognate 90 kDa protein/0.450
2fxsRDAATP-dependent molecular chaperone HSP82/0.449
3d2rADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.449
1uyiPUZHeat shock protein HSP 90-alpha/0.448
2iwsNP4ATP-dependent molecular chaperone HSP82/0.448
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.448
1yc443PHeat shock protein HSP 90-alpha/0.447
1xddAAYIntegrin alpha-L/0.446
2xx413IATP-dependent molecular chaperone HSP82/0.446
2xk2ADPHeat shock protein HSP 90-alpha/0.445
4b7p9UNHeat shock protein HSP 90-alpha/0.445
2npaMMBPeroxisome proliferator-activated receptor alpha/0.444
3pftFMNFlavin reductase/0.444
2ijgFADCryptochrome DASH, chloroplastic/mitochondrial/0.443
3cukFADD-amino-acid oxidase1.4.3.30.443
4ce2BO5ATP-dependent molecular chaperone HSP82/0.442
2qg0A94Heat shock protein HSP 90-alpha/0.441
1yt0ADPEndoplasmin/0.440
3hz5Z64Heat shock protein HSP 90-alpha/0.440