sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2evc | FC3 | Methionine aminopeptidase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2evc | FC3 | Methionine aminopeptidase | / | 1.000 | |
| 2evm | FC2 | Methionine aminopeptidase | / | 0.886 | |
| 2q94 | A04 | Methionine aminopeptidase | / | 0.776 | |
| 2q92 | B23 | Methionine aminopeptidase | / | 0.701 | |
| 3iu7 | FCD | Methionine aminopeptidase 2 | / | 0.649 | |
| 2p99 | YE6 | Methionine aminopeptidase | / | 0.631 | |
| 2gg8 | U15 | Methionine aminopeptidase | / | 0.622 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.608 | |
| 1xnz | FCD | Methionine aminopeptidase | / | 0.593 | |
| 3pkb | Y16 | Methionine aminopeptidase 2 | / | 0.582 | |
| 3pkd | Y10 | Methionine aminopeptidase 2 | / | 0.574 | |
| 2q93 | B21 | Methionine aminopeptidase | / | 0.568 | |
| 2p98 | YE7 | Methionine aminopeptidase | / | 0.562 | |
| 2g6p | HM2 | Methionine aminopeptidase 1 | / | 0.559 | |
| 2q96 | A18 | Methionine aminopeptidase | / | 0.557 | |
| 3iu8 | T03 | Methionine aminopeptidase 2 | / | 0.549 | |
| 4flk | Y10 | Methionine aminopeptidase 1 | / | 0.547 | |
| 4iks | TFD | Methionine aminopeptidase 1 | / | 0.547 | |
| 2nq7 | HM5 | Methionine aminopeptidase 1 | / | 0.542 | |
| 2ggb | U17 | Methionine aminopeptidase | / | 0.540 | |
| 3pka | Y02 | Methionine aminopeptidase 2 | / | 0.537 | |
| 2gg2 | U12 | Methionine aminopeptidase | / | 0.529 | |
| 2gg9 | U16 | Methionine aminopeptidase | / | 0.529 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.525 | |
| 4fli | Y16 | Methionine aminopeptidase 1 | / | 0.521 | |
| 2gg0 | U11 | Methionine aminopeptidase | / | 0.516 | |
| 3d27 | W29 | Methionine aminopeptidase | / | 0.516 | |
| 4iku | SHX | Methionine aminopeptidase 1 | / | 0.516 | |
| 4ikt | TFV | Methionine aminopeptidase 1 | / | 0.515 | |
| 4ikr | PVP | Methionine aminopeptidase 1 | / | 0.507 | |
| 4hxx | 1AY | Methionine aminopeptidase 1 | / | 0.506 | |
| 3iu9 | T07 | Methionine aminopeptidase 2 | / | 0.496 | |
| 4fll | YZ6 | Methionine aminopeptidase 1 | / | 0.485 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.481 | |
| 1qzy | TDE | Methionine aminopeptidase 2 | / | 0.480 | |
| 1c23 | MPH | Methionine aminopeptidase | / | 0.479 | |
| 2gg3 | U13 | Methionine aminopeptidase | / | 0.467 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.466 | |
| 1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.465 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.461 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 5ao1 | DG3 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.453 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.452 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.452 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.452 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.452 | |
| 2gs9 | SAH | Uncharacterized protein | / | 0.449 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.446 | |
| 3pkc | Y08 | Methionine aminopeptidase 2 | / | 0.446 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
| 2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.443 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.443 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.442 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.440 |