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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1jkkANPDeath-associated protein kinase 12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1jkkANPDeath-associated protein kinase 12.7.11.11.000
1ig1ANPDeath-associated protein kinase 12.7.11.10.750
1jklANPDeath-associated protein kinase 12.7.11.10.716
2w4jADPDeath-associated protein kinase 12.7.11.10.703
3gu7ADPDeath-associated protein kinase 12.7.11.10.626
5av3KMPDeath-associated protein kinase 12.7.11.10.588
5av2KMPDeath-associated protein kinase 12.7.11.10.587
3gu83GUDeath-associated protein kinase 12.7.11.10.552
2yaaATPDeath-associated protein kinase 2/0.539
3bqr4RBDeath-associated protein kinase 3/0.537
4ysjADPCalmodulin-like domain protein kinase/0.537
4qnyANPMitogen activated protein kinase, putative/0.531
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.526
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.522
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.513
5aut2ANDeath-associated protein kinase 12.7.11.10.509
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.508
3bu5ATPInsulin receptor2.7.10.10.508
5dosATPAurora kinase A2.7.11.10.508
2ckeIQUDeath-associated protein kinase 2/0.504
3c4zADPRhodopsin kinase/0.501
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.501
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.500
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.496
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.496
4bbfO19Tyrosine-protein kinase JAK2/0.496
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.494
3c4wATPRhodopsin kinase/0.489
3c4xATPRhodopsin kinase/0.488
4eooATPCyclin-dependent kinase 22.7.11.220.486
4xlvACPInsulin receptor2.7.10.10.486
3qc9ADPRhodopsin kinase/0.485
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.485
3lltANPProtein serine/threonine kinase-1/0.482
2j0lANPFocal adhesion kinase 12.7.10.20.481
3zxtACPDeath-associated protein kinase 12.7.11.10.480
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.479
4aqc88ATyrosine-protein kinase JAK2/0.478
1qmzATPCyclin-dependent kinase 22.7.11.220.477
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.477
4l9i8PRRhodopsin kinase/0.477
4jia1K3Tyrosine-protein kinase JAK2/0.476
4qmlANPSerine/threonine-protein kinase 242.7.11.10.476
3lpbNVBTyrosine-protein kinase JAK2/0.475
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.474
4ii5ADPCyclin-dependent kinase 22.7.11.220.472
4c3pACPAurora kinase A2.7.11.10.471
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.470
3ztxZTXAurora kinase B-A2.7.11.10.468
3my5RFZCyclin-dependent kinase 22.7.11.220.467
4hvi19STyrosine-protein kinase JAK32.7.10.20.467
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.467
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.466
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.466
4i3zADPCyclin-dependent kinase 22.7.11.220.465
3qxpX64Cyclin-dependent kinase 22.7.11.220.463
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.462
2qo7ANPEphrin type-A receptor 32.7.10.10.460
4hge15VTyrosine-protein kinase JAK2/0.460
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.459
2uzbC75Cyclin-dependent kinase 22.7.11.220.459
2vu3LZECyclin-dependent kinase 22.7.11.220.459
4wsqKSAAP2-associated protein kinase 12.7.11.10.459
1yvj4STTyrosine-protein kinase JAK32.7.10.20.458
3orpAGSSerine/threonine protein kinase/0.457
3s1h56ZCyclin-dependent kinase 22.7.11.220.457
4e6q0NVTyrosine-protein kinase JAK2/0.456
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.455
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.454
3dqwAGSProto-oncogene tyrosine-protein kinase Src2.7.10.20.454
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.454
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.453
5dnrATPAurora kinase A2.7.11.10.452
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.451
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.450
4crsAGSSerine/threonine-protein kinase N22.7.11.130.448
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.446
5eg3ACPFibroblast growth factor receptor 2/0.446
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.445
3dfcANPDeath-associated protein kinase 12.7.11.10.445
4i5cC5ITyrosine-protein kinase JAK1/0.445
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.444
2cjmATPCyclin-dependent kinase 22.7.11.220.443
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2fvdLIACyclin-dependent kinase 22.7.11.220.442
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.442
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.442
4ehzJAKTyrosine-protein kinase JAK1/0.441
4s33ANPMitogen-activated protein kinase 12.7.11.240.441
3i60E86Mitogen-activated protein kinase 12.7.11.240.440
3uvqFS8Mitogen-activated protein kinase 14/0.440
4o0wADNAurora kinase A2.7.11.10.440