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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1fnbFADFerredoxin--NADP reductase, chloroplastic1.18.1.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1fnbFADFerredoxin--NADP reductase, chloroplastic1.18.1.21.000
1bx1FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.825
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.690
1bx0FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.671
1gawFADFerredoxin/0.632
3vo2FADFerredoxin--NADP reductase/0.630
1gaqFADFerredoxin/0.614
3mhpFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.606
1fncFDAFerredoxin--NADP reductase, chloroplastic1.18.1.20.604
3zc3FADFerredoxin--NADP reductase1.18.1.20.602
1gjrFADFerredoxin--NADP reductase1.18.1.20.594
1sm4FADFerredoxin--NADP reductase/0.588
4c43FADFerredoxin--NADP reductase1.18.1.20.588
1fndFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.582
2rc6FADFerredoxin--NADP reductase/0.581
1w35FADFerredoxin--NADP reductase1.18.1.20.578
1e64FADFerredoxin--NADP reductase1.18.1.20.574
1go2FADFerredoxin--NADP reductase1.18.1.20.572
1qgyFADFerredoxin--NADP reductase1.18.1.20.572
1h85FADFerredoxin--NADP reductase1.18.1.20.571
3w5uFADFerredoxin/0.569
4af6FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.569
1qh0FADFerredoxin--NADP reductase1.18.1.20.564
4bprFADFerredoxin--NADP reductase1.18.1.20.554
2b5oFADFerredoxin--NADP reductase1.18.1.20.549
1h42FADFerredoxin--NADP reductase1.18.1.20.548
1queFADFerredoxin--NADP reductase1.18.1.20.547
1bjkFADFerredoxin--NADP reductase1.18.1.20.544
4yaoFADNADPH--cytochrome P450 reductase/0.538
3zbtFADFerredoxin--NADP reductase1.18.1.20.537
1ogiFADFerredoxin--NADP reductase1.18.1.20.533
1gr1FADFerredoxin--NADP reductase1.18.1.20.532
2ok8FADFerredoxin--NADP reductase, apicoplast/0.530
1ogjFADFerredoxin--NADP reductase1.18.1.20.528
1j9zFADNADPH--cytochrome P450 reductase/0.520
3jqrFADFerredoxin--NADP reductase, apicoplast/0.520
1ja1FADNADPH--cytochrome P450 reductase/0.515
3fpkFADFerredoxin-NADP reductase/0.511
1b2rFADFerredoxin--NADP reductase1.18.1.20.508
1w87FADFerredoxin--NADP reductase1.18.1.20.506
1amoFADNADPH--cytochrome P450 reductase/0.502
4uajFADNa(+)-translocating NADH-quinone reductase subunit F/0.502
3qftFADNADPH--cytochrome P450 reductase/0.498
1e63FADFerredoxin--NADP reductase1.18.1.20.495
1e62FADFerredoxin--NADP reductase1.18.1.20.494
2rc5FADFerredoxin--NADP reductase/0.492
2vnjFADNADPH:ferredoxin reductase/0.491
3qfsFADNADPH--cytochrome P450 reductase/0.488
1qgzFADFerredoxin--NADP reductase1.18.1.20.483
2r6hFADNa(+)-translocating NADH-quinone reductase subunit F/0.480
3rsv3RSBeta-secretase 13.4.23.460.476
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.476
1x27ASP_ASP_TYR_VAL_PTRTyrosine-protein kinase Lck2.7.10.20.474
2xncFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.472
1x1bSAHC-20 methyltransferase/0.469
5dp2NAPCurF/0.469
2zz0FADThioredoxin reductase 1, cytoplasmic1.8.1.90.468
3otwCOAPhosphopantetheine adenylyltransferase/0.467
2vnkFADNADPH:ferredoxin reductase/0.466
1a8pFADFerredoxin--NADP reductase/0.465
2e0nSAHPrecorrin-2 C20-methyltransferase/0.465
3ojxFADNADPH--cytochrome P450 reductase/0.464
1tllFADNitric oxide synthase, brain1.14.13.390.460
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.460
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.459
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.459
2vn1FK5Peptidylprolyl isomerase/0.458
1fdrFADFerredoxin--NADP reductase1.18.1.20.457
2uxoTACHTH-type transcriptional regulator TtgR/0.457
3exfTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.457
3exfTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.457
1z41FMNNADPH dehydrogenase/0.456
2ejzSAHDiphthine synthase/0.456
2gesCOKPantothenate kinase2.7.1.330.456
1opmIYGPeptidyl-glycine alpha-amidating monooxygenase1.14.17.30.454
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.453
3c1oNAPEugenol synthase/0.453
3qfcFADNADPH--cytochrome P450 reductase/0.453
5ah5LSSLeucine--tRNA ligase/0.453
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.452
1xddAAYIntegrin alpha-L/0.452
3aezGDPPantothenate kinase2.7.1.330.452
3frkTQPQdtB/0.452
3m30COMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.452
3m30COMMethyl-coenzyme M reductase I subunit beta2.8.4.10.452
4fse0VABeta-secretase 13.4.23.460.452
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.451
2g8yNADHydroxycarboxylate dehydrogenase B/0.451
4b4dFADFerredoxin-NADP reductase/0.451
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.450
2piaFMNPhthalate dioxygenase reductase/0.450
2zevIPEGeranylgeranyl pyrophosphate synthase/0.450
3busSAHDemethylrebeccamycin-D-glucose O-methyltransferase/0.450
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.447
3q43D66M1 family aminopeptidase3.4.110.447
3m2uCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.446
1x8lOXRRetinol dehydratase/0.445
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.445
3hl0NADMaleylacetate reductase/0.445
4fk8FADFerredoxin--NADP reductase/0.445
4q0kGA3Phytohormone-binding protein/0.444
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.443
4acxS8ZBeta-secretase 13.4.23.460.443
4b7754MBeta-secretase 13.4.23.460.443
2gouFMNNADH:flavin oxidoreductase Sye1/0.442
3zhtTD9Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.442
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.442
4z4pSAHHistone-lysine N-methyltransferase 2D2.1.1.430.442
1bsvNDPGDP-L-fucose synthase/0.441
1oycFMNNADPH dehydrogenase 11.6.99.10.441
3q9bB3NAcetylpolyamine amidohydrolase/0.441
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.441
4i101BSBeta-secretase 13.4.23.460.441
2xlrFADPutative flavin-containing monooxygenase/0.440
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.440
5dldUD1UDP-N-Acetylglucosamine 2-epimerase/0.440