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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
9gssGTXGlutathione S-transferase P2.5.1.18

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
9gssGTXGlutathione S-transferase P2.5.1.181.000
17gsGTXGlutathione S-transferase P2.5.1.180.838
13gsSASGlutathione S-transferase P2.5.1.180.811
12gs0HHGlutathione S-transferase P2.5.1.180.725
2a2sGSNGlutathione S-transferase P2.5.1.180.667
1pgtGTXGlutathione S-transferase P2.5.1.180.654
3pgtGBXGlutathione S-transferase P2.5.1.180.651
1gtiGTBGlutathione S-transferase P 12.5.1.180.641
2oadGTBGlutathione S-transferase P 12.5.1.180.640
2glrGTXGlutathione S-transferase P 12.5.1.180.639
2j9hGTXGlutathione S-transferase P2.5.1.180.639
2oa7GTXGlutathione S-transferase P 12.5.1.180.634
4pgtGBXGlutathione S-transferase P2.5.1.180.629
1aqxGTDGlutathione S-transferase P2.5.1.180.611
3gusN11Glutathione S-transferase P2.5.1.180.589
20gsCBDGlutathione S-transferase P2.5.1.180.584
3ie3N11Glutathione S-transferase P2.5.1.180.582
2pgtGPRGlutathione S-transferase P2.5.1.180.560
1gssLEEGlutathione S-transferase P2.5.1.180.554
3o76GTBGlutathione S-transferase P 12.5.1.180.550
3csjCBLGlutathione S-transferase P2.5.1.180.540
1tu8GTXGlutathione S-transferase 22.5.1.180.539
3n9jEAAGlutathione S-transferase P2.5.1.180.519
2gstGPSGlutathione S-transferase Mu 12.5.1.180.514
1aqv0HGGlutathione S-transferase P2.5.1.180.510
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.503
2oacGTBGlutathione S-transferase P 12.5.1.180.493
2vqbNAPPutative flavin-containing monooxygenase/0.488
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.487
3ai3NDPNADPH-sorbose reductase/0.486
3gstGPRGlutathione S-transferase Mu 12.5.1.180.484
2x3jATPAcsD/0.483
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.481
5dozNDPJamJ/0.481
1xddAAYIntegrin alpha-L/0.479
4bfzZVZPantothenate kinase2.7.1.330.479
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.478
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.478
3br3ETHTH-type transcriptional regulator QacR/0.478
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.476
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.476
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.474
5c2tFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.473
2bb3SAHCobalamin biosynthesis precorrin-6Y methylase (CbiE)/0.470
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.469
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.468
3dgqEAAGlutathione S-transferase P2.5.1.180.468
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.468
1s7lCOAAcetyl transferase/0.467
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.467
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.466
2lfoGCHFatty acid-binding protein, liver/0.466
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.466
1hncGDNGlutathione S-transferase Mu 22.5.1.180.465
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.464
3tr05GPGuanylate kinase/0.464
1akbPPDAspartate aminotransferase, mitochondrial2.6.1.10.463
4bfwZVWPantothenate kinase2.7.1.330.462
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
1cs4FOKAdenylate cyclase type 2/0.460
1cs4FOKAdenylate cyclase type 5/0.460
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.458
4lutDCSAlanine racemase/0.458
2ea4F79Methionine aminopeptidase 2/0.457
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.457
2x7hPFNProstaglandin reductase 310.456
3pm1ETHTH-type transcriptional regulator QacR/0.456
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.455
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.455
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.455
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.455
3eksCY9Actin-5C/0.455
3swqEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.455
1b2lNDCAlcohol dehydrogenase1.1.1.10.454
1h60STRPentaerythritol tetranitrate reductase/0.454
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.453
1towCRZFatty acid-binding protein, adipocyte/0.453
3cb2GDPTubulin gamma-1 chain/0.453
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.453
1gzuNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.452
1s63778Protein farnesyltransferase subunit beta2.5.1.580.452
2cibCM6Lanosterol 14-alpha demethylase1.14.13.700.452
4bfxZVXPantothenate kinase2.7.1.330.452
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
1dgmADNAdenosine kinase2.7.1.200.451
1x1aSAMC-20 methyltransferase/0.451
2po3T4K4-dehydrase/0.451
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.450
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.450
3c3xNAPEugenol synthase 11.1.1.3180.450
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.580.449
2e07SAHDiphthine synthase/0.449
3ekuCY9Actin-5C/0.449
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.448
2h2jSFGRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.448
2qimZEAClass 10 plant pathogenesis-related protein/0.448
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.447
3sxjSAMPutative methyltransferase/0.447
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.447
4ytnFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.447
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.446
2j5xGSPADP-ribosylation factor 6/0.446
3qgf46FGenome polyprotein2.7.7.480.446
1uxyEPUUDP-N-acetylenolpyruvoylglucosamine reductase1.3.1.980.445
2hdjNDPAldo-keto reductase family 1 member C2/0.445
2vprTDCTetracycline repressor protein class H/0.445
3cavCI23-oxo-5-beta-steroid 4-dehydrogenase/0.445
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3e6eDCSAlanine racemase/0.445
3pvrBYC1,2-phenylacetyl-CoA epoxidase, subunit A1.14.13.1490.445
4b4vL34Bifunctional protein FolD/0.445
4df2FMNNADPH dehydrogenase/0.445
1q84TZ4Acetylcholinesterase3.1.1.70.444
1qpl587Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.444
2po7CHDFerrochelatase, mitochondrial4.99.1.10.444
2xupTZ5Acetylcholinesterase3.1.1.70.444
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3pdnSFGHistone-lysine N-methyltransferase SMYD32.1.1.430.444
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.444
4ddhMS0Pantothenate synthetase6.3.2.10.444
4jlm1NNDeoxycytidine kinase2.7.1.740.444
1p0ySAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.443
1xe55FEPlasmepsin-23.4.23.390.443
1yw9A84Methionine aminopeptidase 2/0.443
2g8yNADHydroxycarboxylate dehydrogenase B/0.443
5ckuFADL-ornithine N(5)-monooxygenase/0.443
1l2tATPUncharacterized ABC transporter ATP-binding protein MJ0796/0.442
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.442
1yhjR6CPyridoxal kinase2.7.1.350.442
3b9lAZZSerum albumin/0.442
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.442
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3o03NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase)/0.442
5dp2NAPCurF/0.442
2gv8NDPThiol-specific monooxygenase1.14.130.441
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.441
2b8l5HABeta-secretase 13.4.23.460.440
2yq92AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.440
3b4yF42F420-dependent glucose-6-phosphate dehydrogenase/0.440
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.440
3ggs2FDPurine nucleoside phosphorylase2.4.2.10.440
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4du82P0Mevalonate diphosphate decarboxylase/0.440
5irnADPNucleotide binding oligomerization domain containing 2/0.440