sc-PDB

List of CHEMBLId :

This value allows a number of roughly comparable measures of half-maximal response concentration/potency/affinity to be compared on a negative logarithmic scale (e.g., an IC50 measurement of 1nM would have a pChEMBL value of 9).

Uniprot Annotation

Name:	Protein farnesyltransferase subunit beta
ID:	FNTB_HUMAN
AC:	P49356
Organism:	Homo sapiens
Reign:	Eukaryota
TaxID:	9606
EC Number:	2.5.1.58

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Chains:

Chain Name:	Percentage of Residues within binding site
A	20 %
B	80 %

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Ligand binding site composition:

B-Factor:	14.995
Number of residues:	30
Including
Standard Amino Acids:	28
Non Standard Amino Acids:	1
Water Molecules:	1
Cofactors:
Metals:	ZN

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Cavity properties

Ligandability	Volume (Å3)
0.658	1015.875

% Hydrophobic	% Polar
35.55	64.45
According to VolSite

HET Code:	BNE
Formula:	C28H34N5O2
Molecular weight:	472.602 g/mol
DrugBank ID:	-
Buried Surface Area:	58.56 %
Polar Surface area:	98.79 Å2

Number of
H-Bond Acceptors:	4
H-Bond Donors:	1
Rings:	4
Aromatic rings:	3
Anionic atoms:	0
Cationic atoms:	1
Rule of Five Violation:	0
Rotatable Bonds:	6

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Mass center Coordinates

X	Y	Z
17.1398	133.836	-2.6392

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