sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 1.000 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.647 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.579 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.529 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.522 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.521 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.514 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.513 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.510 | |
| 2vqq | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.503 | |
| 3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.502 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.500 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.500 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.500 | |
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 0.493 | |
| 2pdy | FID | Aldose reductase | 1.1.1.21 | 0.490 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.489 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.488 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.488 | |
| 1ah0 | SBI | Aldose reductase | 1.1.1.21 | 0.487 | |
| 2nvc | ITA | Aldose reductase | 1.1.1.21 | 0.485 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.484 | |
| 2pdk | SBI | Aldose reductase | 1.1.1.21 | 0.484 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.484 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.483 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.483 | |
| 2agt | FID | Aldose reductase | 1.1.1.21 | 0.482 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.481 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.480 | |
| 2is7 | 2CL | Aldose reductase | 1.1.1.21 | 0.480 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.479 | |
| 3u2c | SUZ | Aldose reductase | 1.1.1.21 | 0.478 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.477 | |
| 2dux | ZST | Aldose reductase | 1.1.1.21 | 0.477 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.477 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.477 | |
| 4drh | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.477 | |
| 4drh | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.477 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.477 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.476 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.476 | |
| 4phl | PIL | Phosphodiesterase | / | 0.476 | |
| 1ef3 | FID | Aldose reductase | 1.1.1.21 | 0.475 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.475 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.474 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.474 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.474 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.473 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.473 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.473 | |
| 1pwm | FID | Aldose reductase | 1.1.1.21 | 0.472 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.472 | |
| 1v08 | NTZ | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.472 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.472 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.471 | |
| 2vqo | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.471 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.471 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.470 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
| 2pdw | FID | Aldose reductase | 1.1.1.21 | 0.470 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.468 | |
| 2pd9 | FID | Aldose reductase | 1.1.1.21 | 0.468 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.466 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.466 | |
| 1s36 | CEI | Obelin | / | 0.465 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.465 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 1lke | DOG | Bilin-binding protein | / | 0.463 | |
| 2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.463 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.463 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.463 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.462 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.462 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.461 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.461 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.461 | |
| 1rxj | BNI | Streptavidin | / | 0.460 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 3gn7 | 3GN | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.460 | |
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.460 | |
| 3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.460 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.460 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.459 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.459 | |
| 3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.459 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.458 | |
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 0.458 | |
| 2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.458 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.458 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.458 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.458 | |
| 4a33 | PS8 | Glycylpeptide N-tetradecanoyltransferase | / | 0.458 | |
| 4gab | FID | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.458 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.458 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.457 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.457 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.457 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.457 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.456 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.456 | |
| 3s3g | TLT | Aldose reductase | 1.1.1.21 | 0.456 | |
| 1e1f | PSG | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.455 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.455 | |
| 2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.455 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.455 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.455 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.454 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.454 | |
| 4jqa | ID8 | Aldo-keto reductase family 1 member C2 | / | 0.454 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.453 | |
| 3w0t | HPU | Lactoylglutathione lyase | 4.4.1.5 | 0.453 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.452 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.452 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 4ga8 | SBI | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.452 | |
| 5dsg | 0HK | Muscarinic acetylcholine receptor M4 | / | 0.452 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.451 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3ocw | 3AM | Lipoprotein E | / | 0.451 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.451 | |
| 4jpg | 1OX | Pyruvate kinase PKM | 2.7.1.40 | 0.451 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.450 | |
| 2xnv | VU3 | Soluble acetylcholine receptor | / | 0.450 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.449 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.449 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.449 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.448 | |
| 3cas | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.448 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.448 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.447 | |
| 2f99 | AKV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.447 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.447 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.447 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.446 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.446 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.446 | |
| 2r86 | ATP | 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase | / | 0.446 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.446 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.445 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.445 | |
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.445 | |
| 3g72 | A6T | Renin | 3.4.23.15 | 0.445 | |
| 3htj | ET | EbrA repressor | / | 0.445 | |
| 4jtq | FLP | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.445 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.444 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.444 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.444 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.444 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1el4 | CTZ | Obelin | / | 0.443 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.443 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4tvj | 09L | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.443 | |
| 2xei | ARK | Glutamate carboxypeptidase 2 | 3.4.17.21 | 0.442 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.442 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.442 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.442 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.441 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.441 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4bjb | P34 | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.441 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.440 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.440 | |
| 3b82 | NAD | Exotoxin A | 2.4.2.36 | 0.440 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.440 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.440 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.440 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.440 | |
| 5dsy | UHB | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.440 |