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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.11.000
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.668
3wdsNADNADH-dependent quinuclidinone reductase/0.550
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.547
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.539
4gh5NADShort-chain dehydrogenase/reductase SDR/0.538
4j7xNAPSepiapterin reductase1.1.1.1530.536
5jlaNADPutative short-chain dehydrogenase/reductase/0.532
4j7uNAPSepiapterin reductase1.1.1.1530.528
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.527
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.525
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.524
1zemNADXylitol dehydrogenase/0.521
1ae1NAPTropinone reductase 1/0.520
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.519
3d3wNAPL-xylulose reductase1.1.1.100.519
4yaiNAIC alpha-dehydrogenase/0.517
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.516
2yy7NADL-threonine dehydrogenase/0.516
3ak4NADNADH-dependent quinuclidinone reductase/0.516
3s55NADPutative short-chain dehydrogenase/reductase/0.514
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.511
2dteNAIGlucose 1-dehydrogenase related protein/0.511
3p19NDPPutative blue fluorescent protein/0.511
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.510
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.510
5lc1NADL-threonine 3-dehydrogenase/0.510
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.509
5ig2NADShort-chain dehydrogenase/reductase SDR/0.509
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.508
4fn4NADShort chain dehydrogenase/0.507
1ipeNDPTropinone reductase 21.1.1.2360.506
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.505
1xg5NAPDehydrogenase/reductase SDR family member 11/0.504
2wdzNADGalactitol dehydrogenase/0.503
3lqfNADGalactitol dehydrogenase/0.503
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.503
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.503
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.502
4yagNAIC alpha-dehydrogenase/0.501
4hwkNAPSepiapterin reductase1.1.1.1530.500
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.499
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.498
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.497
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.497
3sx2NADUncharacterized protein/0.496
1x7gNAPPutative ketoacyl reductase1.3.10.493
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.492
1iy8NADLevodione reductase/0.492
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.491
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.491
2wsbNADGalactitol dehydrogenase/0.491
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.491
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.490
1x7hNDPPutative ketoacyl reductase1.3.10.490
3uxyNADShort-chain dehydrogenase/reductase SDR/0.490
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.490
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.489
1snyNAPLD36273p/0.488
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.488
1g6kNADGlucose 1-dehydrogenase1.1.1.470.487
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.487
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.487
2bd0NAPSepiapterin reductase/0.486
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.486
4qecNAPElxO/0.486
4bmvNAPShort-chain dehydrogenase/0.485
3tscNADUncharacterized protein/0.484
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.484
5jydNADShort chain dehydrogenase/0.484
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.483
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.482
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.482
1wntNAPL-xylulose reductase1.1.1.100.481
3gy0NAPNAD(P)-dependent oxidoreductase/0.481
1oaaNAPSepiapterin reductase1.1.1.1530.480
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.480
4esoNAPPutative oxidoreductase/0.479
1n5dNDPCarbonyl reductase [NADPH] 1/0.478
3vdqNAD3-hydroxybutyrate dehydrogenase/0.478
3sjuNDPKeto reductase/0.477
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.476
4cr8NADN-acylmannosamine 1-dehydrogenase1.1.1.2330.476
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.476
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.475
1xkqNDPUncharacterized protein/0.474
2yutNAPPutative short-chain oxidoreductase/0.474
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.473
3rj5NADAlcohol dehydrogenase1.1.1.10.473
3f1kNAPUncharacterized oxidoreductase YciK10.472
3l77NJPShort-chain alcohol dehydrogenase/0.472
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.472
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.472
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.471
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.471
4nbwNADShort-chain dehydrogenase/reductase SDR/0.471
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.470
3w8eNAD3-hydroxybutyrate dehydrogenase/0.469
1w4zNAPPutative ketoacyl reductase1.3.10.467
3gegNADShort-chain dehydrogenase/reductase SDR/0.467
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.467
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.466
3qrwNDPPutative ketoacyl reductase1.3.10.466
3w8fNAD3-hydroxybutyrate dehydrogenase/0.466
4dwvNAJAlcohol dehydrogenase E chain1.1.1.10.466
4ej0NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.465
1b15NAEAlcohol dehydrogenase1.1.1.10.464
5idwNAPShort-chain dehydrogenase/reductase SDR/0.463
4b79NADProbable short-chain dehydrogenase/0.462
1b16NAQAlcohol dehydrogenase1.1.1.10.461
3ai2NDPNADPH-sorbose reductase/0.460
3tn7NJPShort-chain alcohol dehydrogenase/0.460
3ai3NDPNADPH-sorbose reductase/0.458
3bmoNAPPteridine reductase/0.458
4dc1NDPPutative ketoacyl reductase1.3.10.458
1rwbNADGlucose 1-dehydrogenase1.1.1.470.457
3a4vNADNDP-sugar epimerase/0.457
3toxNAPPutative oxidoreductase/0.457
1mgoNADAlcohol dehydrogenase E chain1.1.1.10.456
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.456
3w8dNAD3-hydroxybutyrate dehydrogenase/0.455
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.455
1pr9NAPL-xylulose reductase1.1.1.100.454
3a1nNADNDP-sugar epimerase/0.454
3rj9NADAlcohol dehydrogenase1.1.1.10.454
3uceNDPDehydrogenase/0.453
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.452
2ohxNADAlcohol dehydrogenase E chain1.1.1.10.452
4b8wNAPGDP-L-fucose synthase1.1.1.2710.452
4idgNADPutative UDP-glucose 4-epimerase/0.452
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
3r3sNADPutative oxidoreductase/0.451
1eq2NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.450
2x86NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.450
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.450
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.450
1mg5NAIAlcohol dehydrogenase1.1.1.10.449
2jahNDPClavaldehyde dehydrogenase/0.449
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.449
1geeNADGlucose 1-dehydrogenase1.1.1.470.448
1i2bNADUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.448
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
4ng5NAJAlcohol dehydrogenase E chain1.1.1.10.448
1kvrNADUDP-glucose 4-epimerase5.1.3.20.446
1b14NADAlcohol dehydrogenase1.1.1.10.445
1gcoNADGlucose 1-dehydrogenase1.1.1.470.442
1sbyNADAlcohol dehydrogenase1.1.1.10.442
2p5uNADUDP-glucose 4-epimerase/0.441
4nfhNAJAlcohol dehydrogenase E chain1.1.1.10.441
1sowNADL-lactate dehydrogenase1.1.1.270.440
4cpdNADAlcohol dehydrogenase/0.440
4o0lNDPNADPH-dependent 3-quinuclidinone reductase/0.440