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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.21.000
3zonIK1Non-receptor tyrosine-protein kinase TYK22.7.10.20.508
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.490
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.488
2qoqANPEphrin type-A receptor 32.7.10.10.484
5cnnANPEpidermal growth factor receptor2.7.10.10.484
1qmzATPCyclin-dependent kinase 22.7.11.220.481
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.480
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.480
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.479
4deeADPAurora kinase A2.7.11.10.479
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.479
4y95746Tyrosine-protein kinase/0.479
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.477
3oriAGSSerine/threonine protein kinase/0.476
3vthAPCCarbamoyltransferase/0.475
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.474
4ysjADPCalmodulin-like domain protein kinase/0.473
1b38ATPCyclin-dependent kinase 22.7.11.220.471
3plsANPMacrophage-stimulating protein receptor2.7.10.10.471
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.469
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.469
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.468
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.466
2henADPEphrin type-B receptor 22.7.10.10.465
5dnrATPAurora kinase A2.7.11.10.465
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.464
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.464
1b39ATPCyclin-dependent kinase 22.7.11.220.462
3oroAGSSerine/threonine protein kinase/0.462
3r8vZ62Cyclin-dependent kinase 22.7.11.220.462
4fhpUTPTerminal uridylyltransferase cid1/0.462
3wfjNAD2-dehydropantoate 2-reductase/0.461
4xcvNDPProbable hydroxyacid dehydrogenase protein/0.461
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.460
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.10.460
3orpAGSSerine/threonine protein kinase/0.459
4ix5ANPUncharacterized protein/0.459
4k33ACPFibroblast growth factor receptor 32.7.10.10.459
5cnoANPEpidermal growth factor receptor2.7.10.10.459
1i44ACPInsulin receptor2.7.10.10.458
1ie4T44Transthyretin/0.458
3kmwATPIntegrin-linked protein kinase2.7.11.10.458
3lu7IPXSerum albumin/0.458
3tdvGDPGentamicin resistance protein/0.458
3tqhNDPQuinone oxidoreductase/0.458
4yswFADXanthine dehydrogenase/oxidase/0.458
1dawANPCasein kinase II subunit alpha2.7.11.10.456
2pd7FADVivid PAS protein VVD/0.456
3lpbNVBTyrosine-protein kinase JAK2/0.456
3ormAGSSerine/threonine protein kinase/0.456
1jstATPCyclin-dependent kinase 22.7.11.220.455
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.455
2wqeADPAurora kinase A2.7.11.10.454
4ful0VUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
4xr9TMPCalS8/0.454
5l8lADPAurora kinase A2.7.11.10.454
1hckATPCyclin-dependent kinase 22.7.11.220.453
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.453
1t1rIMB1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.453
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.453
4jia1K3Tyrosine-protein kinase JAK2/0.453
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.453
4f07FADStyrene monooxygenase component 2/0.452
4fvqATPTyrosine-protein kinase JAK2/0.452
4xlvACPInsulin receptor2.7.10.10.452
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.451
3poz03PEpidermal growth factor receptor2.7.10.10.451
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.451
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.450
3iok1P6Tyrosine-protein kinase JAK2/0.450
3qarQARPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4lfiGNPCasein kinase II subunit alpha2.7.11.10.450
4o0uADNAurora kinase A2.7.11.10.450
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.449
2b1pAIZMitogen-activated protein kinase 102.7.11.240.449
2ijmATPFocal adhesion kinase 12.7.10.20.449
3c4zADPRhodopsin kinase/0.449
3fhyATPPyridoxal kinase2.7.1.350.449
3qc9ADPRhodopsin kinase/0.449
5eg3ACPFibroblast growth factor receptor 2/0.449
2i5bADPPyridoxine kinase/0.448
2j0lANPFocal adhesion kinase 12.7.10.20.448
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
3tm0ANPAminoglycoside 3'-phosphotransferase2.7.1.950.448
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.448
4oauADP2-5A-dependent ribonuclease3.1.260.448
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.447
2w4jADPDeath-associated protein kinase 12.7.11.10.447
2yxuATPPyridoxal kinase2.7.1.350.447
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.447
4jrnANPRhoptry kinase family protein/0.447
4lrjANPUncharacterized protein/0.447
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.446
2bkkADPAminoglycoside 3'-phosphotransferase2.7.1.950.446
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.446
2w98P1ZProstaglandin reductase 21.3.1.480.446
3k5uPFQAurora kinase A2.7.11.10.446
4c3pACPAurora kinase A2.7.11.10.446
4hvi19STyrosine-protein kinase JAK32.7.10.20.446
4xj3GTPCyclic GMP-AMP synthase/0.446
1mf0GDPAdenylosuccinate synthetase isozyme 1/0.445
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.445
1ol5ADPAurora kinase A2.7.11.10.445
2j0m4STFocal adhesion kinase 12.7.10.20.445
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.445
2ywwATPAspartate carbamoyltransferase regulatory chain/0.445
4wh3ATPN-acetylhexosamine 1-kinase2.7.1.1620.445
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
5l3rGCPCell division protein FtsY homolog, chloroplastic/0.445
1bygSTUTyrosine-protein kinase CSK/0.444
1h0w207Cyclin-dependent kinase 22.7.11.220.444
2qo7ANPEphrin type-A receptor 32.7.10.10.444
3cukFADD-amino-acid oxidase1.4.3.30.444
3nszANPCasein kinase II subunit alpha2.7.11.10.444
3t8oATPRhodopsin kinase/0.444
3zh8C58Protein kinase C iota type2.7.11.130.444
4qnyANPMitogen activated protein kinase, putative/0.444
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
1jnkANPMitogen-activated protein kinase 102.7.11.240.443
3c4wATPRhodopsin kinase/0.443
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.443
4hge15VTyrosine-protein kinase JAK2/0.443
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4oavACP2-5A-dependent ribonuclease3.1.260.443
4y0xADPSerine/threonine-protein kinase PknG2.7.11.10.443
1ictT44Transthyretin/0.442
1mqbANPEphrin type-A receptor 22.7.10.10.442
2xvdAS6Ephrin type-B receptor 42.7.10.10.442
3efwAK8Aurora kinase A2.7.11.10.442
3ortAGSSerine/threonine protein kinase/0.442
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.442
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
2excJNKMitogen-activated protein kinase 102.7.11.240.440
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.440