sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4ipe | ANP | TNF receptor-associated protein 1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4ipe | ANP | TNF receptor-associated protein 1 | / | 1.000 | |
| 4xcj | ADP | Heat shock cognate 90 kDa protein | / | 0.572 | |
| 2wi5 | ZZ5 | Heat shock protein HSP 90-alpha | / | 0.565 | |
| 4ivg | ANP | TNF receptor-associated protein 1 | / | 0.553 | |
| 2xcm | ADP | Cytosolic heat shock protein 90 | / | 0.549 | |
| 2yef | ANP | Heat shock protein HSP 90-alpha | / | 0.543 | |
| 3ekr | PY9 | Heat shock protein HSP 90-alpha | / | 0.527 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.520 | |
| 2qg0 | A94 | Heat shock protein HSP 90-alpha | / | 0.516 | |
| 2xht | C0Y | Heat shock protein HSP 90-alpha | / | 0.515 | |
| 1qy8 | RDI | Endoplasmin | / | 0.510 | |
| 3vha | VHA | Heat shock protein HSP 90-alpha | / | 0.510 | |
| 4xcl | AGS | Heat shock cognate 90 kDa protein | / | 0.509 | |
| 4xc0 | ACP | Heat shock cognate 90 kDa protein | / | 0.506 | |
| 4xdm | GDM | Heat shock cognate 90 kDa protein | / | 0.506 | |
| 2byi | 2DD | Heat shock protein HSP 90-alpha | / | 0.505 | |
| 2bz5 | AB4 | Heat shock protein HSP 90-alpha | / | 0.505 | |
| 2xk2 | ADP | Heat shock protein HSP 90-alpha | / | 0.502 | |
| 1gjv | AGS | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial | 2.7.11.4 | 0.499 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.498 | |
| 3peh | IBD | Endoplasmin homolog, putative | / | 0.497 | |
| 2yeg | XQG | Heat shock protein HSP 90-alpha | / | 0.496 | |
| 3r4p | FU7 | Heat shock protein HSP 90-alpha | / | 0.495 | |
| 1yc3 | 4BC | Heat shock protein HSP 90-alpha | / | 0.494 | |
| 2bu8 | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.493 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.493 | |
| 2byh | 2D7 | Heat shock protein HSP 90-alpha | / | 0.492 | |
| 2xx2 | 13C | ATP-dependent molecular chaperone HSP82 | / | 0.492 | |
| 4bqj | XKL | Heat shock protein HSP 90-alpha | / | 0.492 | |
| 2bre | KJ2 | ATP-dependent molecular chaperone HSP82 | / | 0.491 | |
| 1yet | GDM | Heat shock protein HSP 90-alpha | / | 0.490 | |
| 3k97 | 4CD | Heat shock protein HSP 90-alpha | / | 0.490 | |
| 2gfd | RDA | Endoplasmin | / | 0.489 | |
| 2vci | 2GJ | Heat shock protein HSP 90-alpha | / | 0.489 | |
| 3r4o | FU3 | Heat shock protein HSP 90-alpha | / | 0.489 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.487 | |
| 2ior | ADP | Chaperone protein HtpG | / | 0.487 | |
| 3d2r | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.487 | |
| 1amw | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.485 | |
| 2bt0 | CT5 | Heat shock protein HSP 90-alpha | / | 0.484 | |
| 4ce1 | 7FK | ATP-dependent molecular chaperone HSP82 | / | 0.484 | |
| 4gqt | ADP | Heat shock protein 90 | / | 0.484 | |
| 1osf | KOS | Heat shock protein HSP 90-alpha | / | 0.481 | |
| 1yc1 | 4BC | Heat shock protein HSP 90-alpha | / | 0.480 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.480 | |
| 1byq | ADP | Heat shock protein HSP 90-alpha | / | 0.479 | |
| 2fyp | RDE | Endoplasmin | / | 0.479 | |
| 2o1u | ANP | Endoplasmin | / | 0.479 | |
| 4b7p | 9UN | Heat shock protein HSP 90-alpha | / | 0.478 | |
| 2e0a | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.476 | |
| 2iwu | NP5 | ATP-dependent molecular chaperone HSP82 | / | 0.476 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.474 | |
| 3k98 | 1RC | Heat shock protein HSP 90-alpha | / | 0.473 | |
| 1yc4 | 43P | Heat shock protein HSP 90-alpha | / | 0.471 | |
| 2vcj | 2EQ | Heat shock protein HSP 90-alpha | / | 0.471 | |
| 3h4l | ANP | DNA mismatch repair protein PMS1 | / | 0.470 | |
| 2o1v | ADP | Endoplasmin | / | 0.469 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.468 | |
| 4asg | 814 | ATP-dependent molecular chaperone HSP82 | / | 0.468 | |
| 3hhu | 819 | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 4ce2 | BO5 | ATP-dependent molecular chaperone HSP82 | / | 0.466 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 4asf | 62U | ATP-dependent molecular chaperone HSP82 | / | 0.464 | |
| 4egh | 0OY | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.463 | |
| 4egi | B2J | Heat shock protein HSP 90-alpha | / | 0.463 | |
| 2hch | N5A | Endoplasmin | / | 0.462 | |
| 2xjx | XJX | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.462 | |
| 4efu | EFU | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 2wi6 | ZZ6 | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 4egk | RDC | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 1u0z | RDC | Endoplasmin | / | 0.459 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.459 | |
| 4wud | ANP | DNA gyrase subunit B | / | 0.457 | |
| 1am1 | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.456 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.456 | |
| 2ye4 | 2FY | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 3q5l | KX2 | Heat shock protein 83-1 | / | 0.455 | |
| 3wha | WHA | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 2exl | GDM | Endoplasmin | / | 0.453 | |
| 3ft5 | MO8 | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 1qy5 | NEC | Endoplasmin | / | 0.452 | |
| 2iws | NP4 | ATP-dependent molecular chaperone HSP82 | / | 0.452 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 3hek | BD0 | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 3k99 | PFT | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 4prx | ADP | DNA gyrase subunit B | / | 0.450 | |
| 2esa | GDM | Endoplasmin | / | 0.449 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 2bsm | BSM | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 4wuc | ANP | DNA gyrase subunit B | / | 0.445 | |
| 1i59 | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.444 | |
| 2zdx | P4A | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.443 | |
| 2xjj | L81 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.441 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.441 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.440 | |
| 2xhr | C0P | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.440 |