sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 1.000 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.623 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.603 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.541 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.531 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.528 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.527 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.512 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.499 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.498 | |
| 4k9v | 6AW | Cytochrome P450 3A4 | / | 0.495 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.490 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.489 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.488 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.488 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.487 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.483 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.480 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.479 | |
| 3nxu | RIT | Cytochrome P450 3A4 | / | 0.479 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.478 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.478 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.477 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.476 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.476 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.476 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.476 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.475 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.475 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.474 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.473 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.473 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.473 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.472 | |
| 3pm0 | BHF | Cytochrome P450 1B1 | / | 0.471 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.471 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.471 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.470 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.469 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.469 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.468 | |
| 1fml | RTL | Retinol dehydratase | / | 0.467 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.467 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.467 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.466 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.465 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.464 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.463 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.462 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.462 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.462 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.462 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.460 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.460 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.459 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.459 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.459 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.458 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 3vqs | JT1 | Genome polyprotein | / | 0.457 | |
| 4eji | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.457 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.455 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.455 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.455 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.455 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.455 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 4egn | TWO | Cytochrome P450 | / | 0.452 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.451 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.451 | |
| 2ibz | UQ6 | Cytochrome b | / | 0.450 | |
| 2j9g | ANP | Biotin carboxylase | 6.3.4.14 | 0.450 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.449 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.449 | |
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.448 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.448 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.448 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.447 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 3cyl | VIT | Basic phospholipase A2 homolog piratoxin-2 | / | 0.447 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.446 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.446 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.446 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.445 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.445 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.442 | |
| 3eej | 53R | Uncharacterized protein | / | 0.442 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.442 | |
| 3gph | OID | Cytochrome P450 2E1 | 1.14.13 | 0.442 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.442 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.442 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.442 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.441 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.441 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.440 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.440 | |
| 1rv1 | IMZ | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.440 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.440 |