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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3qh23NMThiazole tautomerase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3qh23NMThiazole tautomerase/1.000
2tpsTPSThiamine-phosphate synthase/0.492
3giyFMN(S)-mandelate dehydrogenase1.1.99.310.485
1n0hCIEAcetolactate synthase catalytic subunit, mitochondrial2.2.1.60.484
2ok7FADFerredoxin--NADP reductase, apicoplast/0.484
2trtTACTetracycline repressor protein class D/0.483
2o7oDXTTetracycline repressor protein class D/0.482
3sjzGNPTranslation initiation factor 2 subunit gamma/0.477
2eixFADNADH-cytochrome b5 reductase/0.475
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.474
5aglH4BNitric oxide synthase, brain1.14.13.390.474
4idgNADPutative UDP-glucose 4-epimerase/0.473
1t9a1TBAcetolactate synthase catalytic subunit, mitochondrial2.2.1.60.471
6gsxGPSGlutathione S-transferase Mu 12.5.1.180.471
2pmdGNPTranslation initiation factor 2 subunit gamma/0.465
5agkH4BNitric oxide synthase, brain1.14.13.390.465
2gevCOKPantothenate kinase2.7.1.330.464
2w98P1ZProstaglandin reductase 21.3.1.480.463
3dds26BGlycogen phosphorylase, liver form2.4.1.10.463
1qo8FADFumarate reductase flavoprotein subunit/0.462
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.462
2xpvMIYTetracycline repressor protein class D/0.462
4fm80UQBeta-secretase 13.4.23.460.462
4fvzH4BNitric oxide synthase, brain1.14.13.390.462
4g1y0VOVitamin D3 receptor A/0.462
5ifyUMPGlucose-1-phosphate thymidylyltransferase/0.462
2xpwOTCTetracycline repressor protein class D/0.460
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.460
2bpoNAPNADPH--cytochrome P450 reductase/0.458
2e1zB4PPropionate kinase/0.458
3o153NMThiamine-phosphate synthase/0.457
4gtv7TRGeranylgeranyl transferase type-2 subunit beta2.5.1.600.457
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.456
3k9uACOSpermidine N(1)-acetyltransferase/0.456
4ia3BIVVitamin D3 receptor A/0.456
2e77FMNLactate oxidase/0.455
2nliFMNLactate oxidase/0.455
2yvwEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.455
3w6hAZMCarbonic anhydrase 14.2.1.10.455
4y6uUPGGlucosyl-3-phosphoglycerate synthase2.4.1.2660.455
2getCOKPantothenate kinase2.7.1.330.454
3l5lFMNXenobiotic reductase/0.454
2ga9AGSPoly(A) polymerase catalytic subunit2.7.7.190.453
4abzT1CTetracycline repressor protein class D/0.453
4jqh1MFAlr2278 protein/0.453
4xnhACON-terminal acetyltransferase A complex subunit NAT52.3.10.453
1f4fTP3Thymidylate synthase/0.452
2hq9FADMll6688 protein/0.452
2rgjFADFlavin-containing monooxygenase/0.452
3arvSAUChitinase A/0.452
4bfyZVYPantothenate kinase2.7.1.330.452
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.451
2cvzNDP3-hydroxyisobutyrate dehydrogenase/0.451
3zkyWT4Isopenicillin N synthase1.21.3.10.451
4geb0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.451
4ia7BIVVitamin D3 receptor A/0.451
5ckuNAPL-ornithine N(5)-monooxygenase/0.451
1vyrFMNPentaerythritol tetranitrate reductase/0.450
2vbpVB1Isopenicillin N synthase1.21.3.10.450
2y6fM9FIsopenicillin N synthase1.21.3.10.450
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.450
2ftoCB3Thymidylate synthase/0.449
2xviFADPutative flavin-containing monooxygenase/0.449
1fwmCB3Thymidylate synthase/0.448
2harOCCVitamin D3 receptor/0.448
2zsdCOAPantothenate kinase2.7.1.330.448
3qfcNAPNADPH--cytochrome P450 reductase/0.448
4fk1FADPutative thioredoxin reductase/0.448
5cwa0GAAnthranilate synthase component 14.1.3.270.448
5fkmTDCTetracycline repressor protein class D/0.448
2e20B4PPropionate kinase/0.447
2fjaFADAdenylylsulfate reductase, subunit A (AprA)/0.447
3nl6TPSUncharacterized protein/0.447
3p8iFMNPentaerythritol tetranitrate reductase/0.447
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.446
2j6xFMNLactate oxidase/0.446
3ddw055Glycogen phosphorylase, liver form2.4.1.10.446
3icsCOACoenzyme A disulfide reductase/0.446
4xd1T3QQdtf/0.446
2gqtFADUDP-N-acetylenolpyruvoylglucosamine reductase/0.445
4c1fX8ZMetallo-beta-lactamase type 2/0.445
4qms1N1Serine/threonine-protein kinase 242.7.11.10.445
4rjeFNRLactate oxidase/0.445
4yal2AMNADPH--cytochrome P450 reductase/0.445
1dxyNADD-2-hydroxyisocaproate dehydrogenase1.1.10.444
1gheACOAcetyltransferase2.3.10.444
1goxFMNPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.444
1v7aFRCAdenosine deaminase3.5.4.40.444
1w6hTITPlasmepsin-23.4.23.390.444
2xrlDXTTetracycline repressor protein class D/0.444
3vqsJT1Genome polyprotein/0.444
1i3mUD1UDP-glucose 4-epimerase/0.443
2zynBCDPeriplasmic binding protein/0.443
4auxXTCTetracycline repressor protein class D/0.443
4b4w9L9Bifunctional protein FolD/0.443
4d7mTDCTetracycline repressor protein class D/0.443
4g1d0VKVitamin D3 receptor A/0.443
4yl2FMNLactate oxidase/0.443
1qjfACSIsopenicillin N synthase1.21.3.10.442
1udyFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.442
1uyePU9Heat shock protein HSP 90-alpha/0.442
3rucUD2UDP-N-acetylglucosamine 4-epimerase/0.442
4ia1BIVVitamin D3 receptor A/0.442
4y9xUPGGlucosyl-3-phosphoglycerate synthase2.4.1.2660.442
2hcdBIVVitamin D3 receptor A/0.441
2vaxCSCAcetyl-CoA--deacetylcephalosporin C acetyltransferase2.3.1.1750.441
4bfvZVVPantothenate kinase2.7.1.330.441
4coxIMNProstaglandin G/H synthase 21.14.99.10.441
4ia2BIVVitamin D3 receptor A/0.441
5fkoTDCTetracycline repressor protein class D/0.441
1jf2CZHObelin/0.440
1qiqACCIsopenicillin N synthase1.21.3.10.440
1wp4NDP3-hydroxyisobutyrate dehydrogenase/0.440
2yk2YJXHeat shock protein HSP 90-alpha/0.440
2z4w749Geranylgeranyl pyrophosphate synthase/0.440
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
3n19FNRXenobiotic reductase/0.440
4fex0TOAminoglycoside 3'-phosphotransferase AphA1-IAB/0.440
4ifn12OKelch-like ECH-associated protein 1/0.440
8catNDPCatalase1.11.1.60.440