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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3bazNAPHydroxyphenylpyruvate reductase1.1.1.237

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3bazNAPHydroxyphenylpyruvate reductase1.1.1.2371.000
2dbqNAPGlyoxylate reductase1.1.1.260.576
2dbzNAPGlyoxylate reductase1.1.1.260.556
4z0pNDPNAD-dependent dehydrogenase/0.555
5j23A2RPutative 2-hydroxyacid dehydrogenase/0.536
4xcvNDPProbable hydroxyacid dehydrogenase protein/0.533
4weqNAPNAD-dependent dehydrogenase/0.529
2g76NADD-3-phosphoglycerate dehydrogenase1.1.1.950.513
4lcjNADC-terminal-binding protein 2/0.511
4e5nNADPhosphonate dehydrogenase1.20.1.10.509
5bqfNAPProbable hydroxyacid dehydrogenase protein/0.509
4e5kNADPhosphonate dehydrogenase1.20.1.10.506
1dxyNADD-2-hydroxyisocaproate dehydrogenase1.1.10.496
3kb6NADD-lactate dehydrogenase/0.489
2w2lNADD-mandelate dehydrogenase/0.488
2gcgNDPGlyoxylate reductase/hydroxypyruvate reductase1.1.1.790.486
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.483
4nu5NADPhosphonate dehydrogenase1.20.1.10.482
2eklNADD-3-phosphoglycerate dehydrogenase/0.481
4e5mNAPPhosphonate dehydrogenase1.20.1.10.481
1wwkNAD307aa long hypothetical phosphoglycerate dehydrogenase/0.480
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.477
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.476
2p9cNAID-3-phosphoglycerate dehydrogenase1.1.1.950.474
2g5cNADPrephenate dehydrogenase/0.472
2dteNAIGlucose 1-dehydrogenase related protein/0.468
1ipeNDPTropinone reductase 21.1.1.2360.467
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.467
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.466
2omeNADC-terminal-binding protein 2/0.464
4dshFDAUncharacterized protein/0.464
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.464
5jlaNADPutative short-chain dehydrogenase/reductase/0.463
3mj4FADUDP-galactopyranose mutase/0.462
3f3sNADLambda-crystallin homolog/0.461
1tw4CHDFatty acid-binding protein, liver/0.460
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.460
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.459
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.459
3gggNADPrephenate dehydrogenase/0.459
4j7xNAPSepiapterin reductase1.1.1.1530.459
1pr9NAPL-xylulose reductase1.1.1.100.458
1ybmNAPUncharacterized protein At5g02240/0.458
4nu6NADPhosphonate dehydrogenase1.20.1.10.458
2daaDCSD-alanine aminotransferase2.6.1.210.457
2yutNAPPutative short-chain oxidoreductase/0.457
1hkuNADC-terminal-binding protein 11.1.10.456
3bgxMEFThymidylate synthase/0.456
3he3FADUDP-galactopyranose mutase/0.456
2cvzNDP3-hydroxyisobutyrate dehydrogenase/0.455
4n9wGDPPhosphatidyl-myo-inositol mannosyltransferase2.4.1.570.455
1psdNADD-3-phosphoglycerate dehydrogenase1.1.1.950.454
3hdyFDAUDP-galactopyranose mutase/0.454
1e3eNAIAlcohol dehydrogenase 41.1.1.10.453
1oaaNAPSepiapterin reductase1.1.1.1530.452
3bhrTHGThymidylate synthase/0.452
1h6cNDPGlucose--fructose oxidoreductase1.1.99.280.451
1mjbACOHistone acetyltransferase ESA1/0.451
1snyNAPLD36273p/0.451
2q3eNAIUDP-glucose 6-dehydrogenase1.1.1.220.450
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.450
5hwsNAP2-dehydropantoate 2-reductase/0.450
2qo6CHDFatty acid-binding protein 10-A, liver basic/0.449
3k4nFADPyranose 2-oxidase/0.449
3mnrSD1Heat shock protein HSP 90-alpha/0.449
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.449
1blzACVIsopenicillin N synthase1.21.3.10.447
1i2bNADUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.447
1x7gNAPPutative ketoacyl reductase1.3.10.447
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.447
2b9yFADPutative aminooxidase/0.447
2wsbNADGalactitol dehydrogenase/0.447
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
3jynNDPQuinone oxidoreductase/0.447
3t2zFADSulfide-quinone reductase/0.447
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.446
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.445
1krhFADBenzoate 1,2-dioxygenase electron transfer component1.18.1.30.445
1ybaNADD-3-phosphoglycerate dehydrogenase1.1.1.950.444
3cinNADMyo-inositol-1-phosphate synthase-related protein/0.444
4at8ATPInterleukin enhancer-binding factor 2/0.444
1hwzNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.443
1wn3HXCPhenylacetic acid degradation protein PaaI/0.443
2igoFADPyranose 2-oxidase/0.443
2yj5ATPCopper-transporting ATPase/0.443
3sjuNDPKeto reductase/0.443
2ft9CHDFatty acid-binding protein 2, liver/0.442
2qocANPEphrin type-A receptor 32.7.10.10.442
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.442
3ptzNADUDP-glucose 6-dehydrogenase1.1.1.220.442
3sufSUEPolyprotein/0.442
4hwkNAPSepiapterin reductase1.1.1.1530.442
4j7uNAPSepiapterin reductase1.1.1.1530.442
4panGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.442
1bv9XV6Gag-Pol polyprotein3.4.23.160.441
1ruoCMPcAMP-activated global transcriptional regulator CRP/0.441
2aa3AP0L-lactate dehydrogenase/0.441
2qo9ANPEphrin type-A receptor 32.7.10.10.441
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
3cukFADD-amino-acid oxidase1.4.3.30.441
1qiqACCIsopenicillin N synthase1.21.3.10.440
1qp8NDP2-hydroxyacid dehydrogenase/0.440
3qrwNDPPutative ketoacyl reductase1.3.10.440
3u4cNDPNADPH-dependent reductase BacG/0.440
3uylTYDProbable NDP-rhamnosyltransferase/0.440
4dbzNDPPutative ketoacyl reductase1.3.10.440
4rpjFADUDP-galactopyranose mutase5.4.99.90.440