sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 1.000 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.677 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.674 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.661 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.658 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.636 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.632 | |
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.631 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.631 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.630 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.626 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.624 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.623 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.622 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.621 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.621 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.617 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.612 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.611 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.610 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.608 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.607 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.607 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.606 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.605 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.604 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.603 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.603 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.600 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.598 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.598 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.597 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.594 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.593 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.589 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.588 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.586 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.586 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.586 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.586 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.585 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.582 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.580 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.580 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.579 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.578 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.577 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.576 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.568 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.563 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.560 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.556 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.553 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.552 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.549 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.549 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.545 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.543 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.539 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.508 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.506 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.504 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.501 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.500 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.499 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.497 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.497 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.492 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.490 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.487 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.487 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.482 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.480 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.480 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.477 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.477 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.472 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.472 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.472 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.469 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.467 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.467 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.465 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.465 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.463 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.462 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.462 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.460 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.460 | |
| 3nxu | RIT | Cytochrome P450 3A4 | / | 0.459 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.459 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.459 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.459 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.457 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.456 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.455 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.455 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.451 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.451 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.450 | |
| 4dvq | 1CA | Cytochrome P450 11B2, mitochondrial | 1.14.15.4 | 0.450 | |
| 4egn | TWO | Cytochrome P450 | / | 0.450 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 3eel | 53T | Uncharacterized protein | / | 0.449 | |
| 3eej | 53R | Uncharacterized protein | / | 0.448 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.448 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.448 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.448 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.446 | |
| 4efu | EFU | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.446 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.446 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.446 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3cyl | VIT | Basic phospholipase A2 homolog piratoxin-2 | / | 0.445 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.445 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.445 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.445 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.444 | |
| 3cse | N22 | Uncharacterized protein | / | 0.444 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.444 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.444 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.443 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.443 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.443 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2nnh | REA | Cytochrome P450 2C8 | / | 0.442 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.442 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.442 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.442 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.442 | |
| 1yw2 | PGJ | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.441 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.441 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.440 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.440 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.440 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.440 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.440 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.440 |