sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2ye4 | 2FY | Heat shock protein HSP 90-alpha |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2ye4 | 2FY | Heat shock protein HSP 90-alpha | / | 1.000 | |
| 2vci | 2GJ | Heat shock protein HSP 90-alpha | / | 0.663 | |
| 4egh | 0OY | Heat shock protein HSP 90-alpha | / | 0.626 | |
| 2bsm | BSM | Heat shock protein HSP 90-alpha | / | 0.617 | |
| 4fcq | 2N6 | Heat shock protein HSP 90-alpha | / | 0.602 | |
| 2yjw | YJW | Heat shock protein HSP 90-alpha | / | 0.600 | |
| 2wi5 | ZZ5 | Heat shock protein HSP 90-alpha | / | 0.576 | |
| 2wi6 | ZZ6 | Heat shock protein HSP 90-alpha | / | 0.568 | |
| 2vcj | 2EQ | Heat shock protein HSP 90-alpha | / | 0.560 | |
| 4ipe | ANP | TNF receptor-associated protein 1 | / | 0.560 | |
| 2yi6 | 6QM | Heat shock protein HSP 90-alpha | / | 0.558 | |
| 2wi1 | ZZ2 | Heat shock protein HSP 90-alpha | / | 0.554 | |
| 3k97 | 4CD | Heat shock protein HSP 90-alpha | / | 0.554 | |
| 2yec | XQ0 | Heat shock protein HSP 90-alpha | / | 0.547 | |
| 2uwd | 2GG | Heat shock protein HSP 90-alpha | / | 0.544 | |
| 3rlq | 3RQ | Heat shock protein HSP 90-alpha | / | 0.544 | |
| 2cct | 2E1 | Heat shock protein HSP 90-alpha | / | 0.541 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.541 | |
| 2ye9 | 2D4 | Heat shock protein HSP 90-alpha | / | 0.539 | |
| 4xcj | ADP | Heat shock cognate 90 kDa protein | / | 0.535 | |
| 2wi2 | ZZ3 | Heat shock protein HSP 90-alpha | / | 0.531 | |
| 1yc1 | 4BC | Heat shock protein HSP 90-alpha | / | 0.527 | |
| 2xcm | ADP | Cytosolic heat shock protein 90 | / | 0.524 | |
| 3hyz | 42C | Heat shock protein HSP 90-alpha | / | 0.520 | |
| 3ekr | PY9 | Heat shock protein HSP 90-alpha | / | 0.519 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.515 | |
| 3ft5 | MO8 | Heat shock protein HSP 90-alpha | / | 0.514 | |
| 4ivg | ANP | TNF receptor-associated protein 1 | / | 0.513 | |
| 1byq | ADP | Heat shock protein HSP 90-alpha | / | 0.512 | |
| 4egk | RDC | Heat shock protein HSP 90-alpha | / | 0.511 | |
| 4xcl | AGS | Heat shock cognate 90 kDa protein | / | 0.511 | |
| 1yc3 | 4BC | Heat shock protein HSP 90-alpha | / | 0.510 | |
| 2qg0 | A94 | Heat shock protein HSP 90-alpha | / | 0.506 | |
| 2xht | C0Y | Heat shock protein HSP 90-alpha | / | 0.505 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.504 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.502 | |
| 4fcr | 0TM | Heat shock protein HSP 90-alpha | / | 0.502 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.501 | |
| 4xc0 | ACP | Heat shock cognate 90 kDa protein | / | 0.500 | |
| 4egi | B2J | Heat shock protein HSP 90-alpha | / | 0.497 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.496 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.494 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.494 | |
| 2bz5 | AB4 | Heat shock protein HSP 90-alpha | / | 0.493 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.493 | |
| 2yef | ANP | Heat shock protein HSP 90-alpha | / | 0.492 | |
| 1osf | KOS | Heat shock protein HSP 90-alpha | / | 0.491 | |
| 2xd6 | XD6 | ATP-dependent molecular chaperone HSP82 | / | 0.490 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.489 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.488 | |
| 2xjj | L81 | Heat shock protein HSP 90-alpha | / | 0.487 | |
| 2byi | 2DD | Heat shock protein HSP 90-alpha | / | 0.486 | |
| 2gfd | RDA | Endoplasmin | / | 0.485 | |
| 2ccu | 2D9 | Heat shock protein HSP 90-alpha | / | 0.484 | |
| 2gqp | PA7 | Endoplasmin | / | 0.484 | |
| 2yej | ZZ3 | Heat shock protein HSP 90-alpha | / | 0.484 | |
| 2o1u | ANP | Endoplasmin | / | 0.481 | |
| 3eko | PYU | Heat shock protein HSP 90-alpha | / | 0.481 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.479 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.479 | |
| 3vha | VHA | Heat shock protein HSP 90-alpha | / | 0.477 | |
| 2iws | NP4 | ATP-dependent molecular chaperone HSP82 | / | 0.476 | |
| 1yet | GDM | Heat shock protein HSP 90-alpha | / | 0.475 | |
| 2ior | ADP | Chaperone protein HtpG | / | 0.475 | |
| 4ffr | ATP | Uncharacterized protein | / | 0.472 | |
| 2yi7 | BZ8 | Heat shock protein HSP 90-alpha | / | 0.468 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 3cs8 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.467 | |
| 3k5u | PFQ | Aurora kinase A | 2.7.11.1 | 0.466 | |
| 2bt0 | CT5 | Heat shock protein HSP 90-alpha | / | 0.465 | |
| 1yc4 | 43P | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 2iwu | NP5 | ATP-dependent molecular chaperone HSP82 | / | 0.464 | |
| 4b7p | 9UN | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.463 | |
| 4asg | 814 | ATP-dependent molecular chaperone HSP82 | / | 0.462 | |
| 4xdm | GDM | Heat shock cognate 90 kDa protein | / | 0.462 | |
| 2xjx | XJX | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 2xk2 | ADP | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 3r4p | FU7 | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 4o0u | ADN | Aurora kinase A | 2.7.11.1 | 0.460 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.459 | |
| 2bre | KJ2 | ATP-dependent molecular chaperone HSP82 | / | 0.459 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.459 | |
| 1uyi | PUZ | Heat shock protein HSP 90-alpha | / | 0.458 | |
| 2c0o | L2G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.455 | |
| 2yeg | XQG | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 2yk2 | YJW | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 3k99 | PFT | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 4jb1 | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.454 | |
| 4bri | UNP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.453 | |
| 4eh3 | NAR | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 2bxe | 1FL | Serum albumin | / | 0.451 | |
| 2o1v | ADP | Endoplasmin | / | 0.451 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.450 | |
| 4awp | 99A | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 4bbg | V02 | Kinesin-like protein KIF11 | / | 0.450 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.450 | |
| 3fnl | SHA | Lactoperoxidase | / | 0.449 | |
| 2fyp | RDE | Endoplasmin | / | 0.448 | |
| 3k98 | 1RC | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 3qwj | X6A | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 4ce1 | 7FK | ATP-dependent molecular chaperone HSP82 | / | 0.447 | |
| 1ny3 | ADP | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.446 | |
| 1u0z | RDC | Endoplasmin | / | 0.446 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3peh | IBD | Endoplasmin homolog, putative | / | 0.446 | |
| 3w32 | W32 | Epidermal growth factor receptor | 2.7.10.1 | 0.446 | |
| 1ijh | FAD | Cholesterol oxidase | 1.1.3.6 | 0.445 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.445 | |
| 4ffl | ADP | Uncharacterized protein | / | 0.445 | |
| 4l9y | 1VU | L-malyl-CoA/beta-methylmalyl-CoA lyase | 4.1.3.24 | 0.445 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 2byh | 2D7 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 2pvh | P19 | Casein kinase II subunit alpha | 2.7.11.1 | 0.444 | |
| 4d9t | 0JG | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.444 | |
| 1t7i | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 2r38 | G4G | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3lfa | 1N1 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3qk0 | QK0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4fx9 | FAD | Coenzyme A disulfide reductase | 1.8.1.14 | 0.443 | |
| 4l9i | 8PR | Rhodopsin kinase | / | 0.443 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.443 | |
| 2wer | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.442 | |
| 3g6w | GTP | Uracil phosphoribosyltransferase | 2.4.2.9 | 0.442 | |
| 4ike | ADP | Adenylate kinase | / | 0.442 | |
| 3cps | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.441 | |
| 4c77 | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.441 | |
| 1eu1 | MGD | Dimethyl sulfoxide/trimethylamine N-oxide reductase | / | 0.440 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.440 | |
| 1lev | CLI | Fructose-1,6-bisphosphatase 1 | 3.1.3.11 | 0.440 | |
| 3q8h | AO9 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.440 | |
| 4i8x | 6P3 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.440 | |
| 5c03 | AGS | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.440 |