scPDB - Distribution of Binding site Similarity values of 2xke entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2xke	WI2	Serine/threonine-protein kinase Nek2	2.7.11.1

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
2xke	WI2	Serine/threonine-protein kinase Nek2	2.7.11.1	1.000
2wqo	VGK	Serine/threonine-protein kinase Nek2	2.7.11.1	0.632
2xkd	T3M	Serine/threonine-protein kinase Nek2	2.7.11.1	0.610
2yac	937	Serine/threonine-protein kinase PLK1	2.7.11.21	0.609
2xkf	BX1	Serine/threonine-protein kinase Nek2	2.7.11.1	0.602
4a4x	JUP	Serine/threonine-protein kinase Nek2	2.7.11.1	0.573
2xk8	5R1	Serine/threonine-protein kinase Nek2	2.7.11.1	0.551
2xk3	XK3	Serine/threonine-protein kinase Nek2	2.7.11.1	0.548
2z2w	770	Wee1-like protein kinase	2.7.10.2	0.545
4j52	1J3	Serine/threonine-protein kinase PLK1	2.7.11.21	0.545
2owb	626	Serine/threonine-protein kinase PLK1	2.7.11.21	0.536
2xk4	OL2	Serine/threonine-protein kinase Nek2	2.7.11.1	0.535
2in6	839	Wee1-like protein kinase	2.7.10.2	0.534
2rku	R78	Serine/threonine-protein kinase PLK1	2.7.11.21	0.534
2w5a	ADP	Serine/threonine-protein kinase Nek2	2.7.11.1	0.533
4a4l	939	Serine/threonine-protein kinase PLK1	2.7.11.21	0.532
2xno	ED8	Serine/threonine-protein kinase Nek2	2.7.11.1	0.528
4b6l	9ZP	Serine/threonine-protein kinase PLK3	2.7.11.21	0.528
2xk6	EQH	Serine/threonine-protein kinase Nek2	2.7.11.1	0.525
4a4o	664	Serine/threonine-protein kinase PLK1	2.7.11.21	0.525
4i6f	1C7	Serine/threonine-protein kinase PLK2	2.7.11.21	0.525
4afe	GGY	Serine/threonine-protein kinase Nek2	2.7.11.1	0.524
4j53	1J4	Serine/threonine-protein kinase PLK1	2.7.11.21	0.517
2xk7	30E	Serine/threonine-protein kinase Nek2	2.7.11.1	0.516
3cr0	809	Wee1-like protein kinase	2.7.10.2	0.514
2xnp	WCX	Serine/threonine-protein kinase Nek2	2.7.11.1	0.512
4fk3	325	Serine/threonine-protein kinase B-raf	2.7.11.1	0.512
4f1m	ACP	Probable serine/threonine-protein kinase roco4	2.7.11.1	0.510
2xnn	430	Serine/threonine-protein kinase Nek2	2.7.11.1	0.506
4i6h	1C8	Serine/threonine-protein kinase PLK2	2.7.11.21	0.506
3biz	61E	Wee1-like protein kinase	2.7.10.2	0.501
2io6	330	Wee1-like protein kinase	2.7.10.2	0.499
2a19	ANP	Interferon-induced, double-stranded RNA-activated protein kinase	2.7.11.1	0.495
1x8b	824	Wee1-like protein kinase	2.7.10.2	0.492
2fb8	215	Serine/threonine-protein kinase B-raf	2.7.11.1	0.486
3bi6	396	Wee1-like protein kinase	2.7.10.2	0.483
3ctj	320	Hepatocyte growth factor receptor	2.7.10.1	0.482
4f1o	ACP	Probable serine/threonine-protein kinase roco4	2.7.11.1	0.482
2xnm	WGZ	Serine/threonine-protein kinase Nek2	2.7.11.1	0.478
3cqe	P91	Wee1-like protein kinase	2.7.10.2	0.478
3aba	FLI	Cytochrome P450	/	0.476
2xck	MH4	3-phosphoinositide-dependent protein kinase 1	2.7.11.1	0.475
4f0f	ACP	Probable serine/threonine-protein kinase roco4	2.7.11.1	0.474
4ftt	6HK	Serine/threonine-protein kinase Chk1	2.7.11.1	0.473
3cgy	RDC	Virulence sensor histidine kinase PhoQ	2.7.13.3	0.472
4ft0	HK9	Serine/threonine-protein kinase Chk1	2.7.11.1	0.472
2xtb	KRM	Adenosine kinase, putative	/	0.466
4bkz	1WS	Maternal embryonic leucine zipper kinase	2.7.11.1	0.466
2xf3	J01	Uncharacterized protein	/	0.460
3sqw	ANP	ATP-dependent RNA helicase MSS116, mitochondrial	3.6.4.13	0.459
4jqe	ANP	Casein kinase II subunit alpha	2.7.11.1	0.459
1c3x	8IG	Purine nucleoside phosphorylase	2.4.2.1	0.458
2bfp	H4B	Pteridine reductase 1	1.5.1.33	0.458
2hog	710	Serine/threonine-protein kinase Chk1	2.7.11.1	0.458
3d5w	ADP	Serine/threonine-protein kinase PLK	/	0.458
2bfa	CB3	Pteridine reductase 1	1.5.1.33	0.456
2pbw	DOQ	Glutamate receptor ionotropic, kainate 1	/	0.456
4fsn	A58	Serine/threonine-protein kinase Chk1	2.7.11.1	0.455
4nb6	444	Nuclear receptor ROR-gamma	/	0.455
1blz	ACV	Isopenicillin N synthase	1.21.3.1	0.453
1e92	HBI	Pteridine reductase 1	1.5.1.33	0.453
1p8d	CO1	Oxysterols receptor LXR-beta	/	0.453
3h4v	DVP	Pteridine reductase 1	1.5.1.33	0.453
3n62	XFJ	Nitric oxide synthase, brain	1.14.13.39	0.453
3wsb	RWZ	Farnesyltransferase, putative	/	0.453
1qpj	STU	Tyrosine-protein kinase Lck	2.7.10.2	0.452
2obx	INI	6,7-dimethyl-8-ribityllumazine synthase 2	2.5.1.78	0.452
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.452
1eji	THF	Serine hydroxymethyltransferase, cytosolic	/	0.451
1pkf	EPD	Epothilone C/D epoxidase	1.14	0.451
2w5b	AGS	Serine/threonine-protein kinase Nek2	2.7.11.1	0.451
3arv	SAU	Chitinase A	/	0.451
3lfe	Z84	Mitogen-activated protein kinase 14	/	0.451
3zky	WT4	Isopenicillin N synthase	1.21.3.1	0.451
3rey	XAC	Adenosine receptor A2a	/	0.451
3gc9	B45	Mitogen-activated protein kinase 11	2.7.11.24	0.450
3qm4	PN0	Cytochrome P450 2D6	/	0.450
4fti	H7K	Serine/threonine-protein kinase Chk1	2.7.11.1	0.449
2vcm	M11	Isopenicillin N synthase	1.21.3.1	0.448
3prf	FP3	Serine/threonine-protein kinase B-raf	2.7.11.1	0.448
4ea2	RWZ	Dehydrosqualene synthase	/	0.448
1ia9	ANP	Transient receptor potential cation channel subfamily M member 7	2.7.11.1	0.447
2pr2	DG1	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.447
2y98	MIV	Mycinamicin IV hydroxylase/epoxidase	/	0.447
1nqv	LMZ	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.446
1q5d	EPB	Epothilone C/D epoxidase	1.14	0.446
1xuo	LA1	Integrin alpha-L	/	0.446
2rjp	886	A disintegrin and metalloproteinase with thrombospondin motifs 4	3.4.24.82	0.446
3byz	H11	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.446
3qd3	3Q5	3-phosphoinositide-dependent protein kinase 1	2.7.11.1	0.446
3ju8	NAD	N-succinylglutamate 5-semialdehyde dehydrogenase	1.2.1.71	0.445
3w1w	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.445
4bbh	YBN	Glycylpeptide N-tetradecanoyltransferase	/	0.445
4zhi	ADP	Kinesin-like protein KIF11	/	0.445
2vbp	VB1	Isopenicillin N synthase	1.21.3.1	0.444
4gki	0JN	Aminoglycoside 3'-phosphotransferase AphA1-IAB	/	0.444
4j97	ACP	Fibroblast growth factor receptor 2	/	0.444
3rfm	CFF	Adenosine receptor A2a	/	0.444
1p33	MTX	Pteridine reductase 1	1.5.1.33	0.443
1w7h	3IP	Mitogen-activated protein kinase 14	/	0.443
2z7g	EH9	Adenosine deaminase	3.5.4.4	0.443
3l8s	BFF	Mitogen-activated protein kinase 14	/	0.443
3n65	XFJ	Nitric oxide synthase, brain	1.14.13.39	0.443
3ppk	FNI	Serine/threonine-protein kinase B-raf	2.7.11.1	0.443
3tda	PN0	Cytochrome P450 2D6	/	0.443
1crb	RTL	Retinol-binding protein 1	/	0.442
2bf7	HBI	Pteridine reductase 1	1.5.1.33	0.442
2c1z	KMP	Anthocyanidin 3-O-glucosyltransferase 2	2.4.1.115	0.442
2olc	ADP	Methylthioribose kinase	2.7.1.100	0.442
2po7	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.442
2rbe	ZMG	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.442
3b04	OOP	Isopentenyl-diphosphate delta-isomerase	/	0.442
3gb4	D3M	DdmC	/	0.442
3hzi	ATP	Serine/threonine-protein kinase toxin HipA	/	0.442
3lla	ACP	Myosin heavy chain kinase A	2.7.11.7	0.442
4r20	AER	Cytochrome P450 family 17 polypeptide 2	/	0.442
4twn	B96	Ephrin type-A receptor 3	2.7.10.1	0.442
5c6c	CMP	cGMP-dependent protein kinase 2	2.7.11.12	0.442
1dr3	HBI	Dihydrofolate reductase	1.5.1.3	0.441
1nm6	L86	Prothrombin	3.4.21.5	0.441
1oc1	ASV	Isopenicillin N synthase	1.21.3.1	0.441
2jc6	QPP	Calcium/calmodulin-dependent protein kinase type 1D	2.7.11.17	0.441
4iae	1DX	Alr2278 protein	/	0.441
1mkd	ZAR	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.440
3bxx	QUE	Dihydroflavonol 4-reductase	1.1.1.219	0.440
3c35	KAI	Glutamate receptor ionotropic, kainate 1	/	0.440
3ews	ADP	ATP-dependent RNA helicase DDX19B	3.6.4.13	0.440
3p9t	TCL	Repressor	/	0.440
4c3y	ANB	3-ketosteroid dehydrogenase	/	0.440
4iah	1DX	Alr2278 protein	/	0.440
4qer	STL	Phospholipase A2 VRV-PL-VIIIa	/	0.440