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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2j4z626Aurora kinase A2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2j4z626Aurora kinase A2.7.11.11.000
3k5uPFQAurora kinase A2.7.11.10.505
4jbqVX6Aurora kinase A2.7.11.10.503
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.502
3e5aVX6Aurora kinase A2.7.11.10.500
3efwAK8Aurora kinase A2.7.11.10.496
2bfyH1NAurora kinase B-A2.7.11.10.494
1bygSTUTyrosine-protein kinase CSK/0.489
5drdATPAurora kinase A2.7.11.10.488
3cgfJNFMitogen-activated protein kinase 102.7.11.240.487
3gc8B45Mitogen-activated protein kinase 112.7.11.240.486
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.486
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.485
3vt8YI3Vitamin D3 receptor/0.482
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.476
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.476
5dr9SKEAurora kinase A2.7.11.10.474
2xikJ60Serine/threonine-protein kinase 252.7.11.10.472
3dtcVINMitogen-activated protein kinase kinase kinase 92.7.11.250.472
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.471
4jboWPHAurora kinase A2.7.11.10.470
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.469
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.469
5dt4ATPAurora kinase A2.7.11.10.469
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.468
5e8wSTUTGF-beta receptor type-12.7.11.300.468
1bwsNDPGDP-L-fucose synthase/0.466
2xneASHAurora kinase A2.7.11.10.466
4gg70J8Hepatocyte growth factor receptor2.7.10.10.466
5dr2ATPAurora kinase A2.7.11.10.466
2xru400Aurora kinase A2.7.11.10.465
4qmzB49Serine/threonine-protein kinase 242.7.11.10.465
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.464
5l8lADPAurora kinase A2.7.11.10.464
2wqeADPAurora kinase A2.7.11.10.463
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.463
2zdt46CMitogen-activated protein kinase 102.7.11.240.463
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.463
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.463
5dosATPAurora kinase A2.7.11.10.463
2pym1UNGag-Pol polyprotein3.4.23.160.462
3a60STURibosomal protein S6 kinase beta-12.7.11.10.462
4b7xNAPProbable oxidoreductase/0.462
3tqhNDPQuinone oxidoreductase/0.461
4b8mVX6Aurora kinase B-A2.7.11.10.461
4o0uADNAurora kinase A2.7.11.10.461
4dymIYZActivin receptor type-12.7.11.300.460
4utdACPAurora kinase A2.7.11.10.460
2vx17X8Ephrin type-B receptor 42.7.10.10.459
4b7dQLECytochrome P450 monooxygenase PikC/0.459
1ol5ADPAurora kinase A2.7.11.10.458
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.458
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.457
1iyzNDPProbable quinone oxidoreductase/0.457
3ogqAB1Pol polyprotein/0.457
3zuxTCHTransporter/0.457
4b0gVEKAurora kinase A2.7.11.10.457
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.457
4fob0USALK tyrosine kinase receptor2.7.10.10.457
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.457
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.456
2dwbANPAurora kinase A2.7.11.10.456
5hsaFASAlcohol oxidase 11.1.3.130.456
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.455
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.455
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.455
4c57FEFCyclin-G-associated kinase2.7.11.10.455
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.455
4j54G52Gag-Pol polyprotein3.4.23.160.455
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.454
2hog710Serine/threonine-protein kinase Chk12.7.11.10.454
2qo9ANPEphrin type-A receptor 32.7.10.10.454
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.454
4jbpYPHAurora kinase A2.7.11.10.454
4o0wADNAurora kinase A2.7.11.10.454
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.453
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.453
1u4dDBQActivated CDC42 kinase 1/0.453
2x6dX6DAurora kinase A2.7.11.10.453
3em6017Gag-Pol polyprotein3.4.23.160.453
3ttjJBIMitogen-activated protein kinase 102.7.11.240.453
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.453
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.453
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
1pmn984Mitogen-activated protein kinase 102.7.11.240.452
2np8CC3Aurora kinase A2.7.11.10.452
2v7a627Tyrosine-protein kinase ABL12.7.10.20.452
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.452
3w2cN15Aurora kinase A2.7.11.10.452
4j55031Gag-Pol polyprotein3.4.23.160.452
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.451
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.451
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.451
1hiiC20Gag-Pol polyprotein/0.450
1pjkANPCasein kinase II subunit alpha2.7.11.10.450
3qn8NI7Gag-Pol polyprotein3.4.23.160.450
3t14FADSulfide-quinone reductase/0.450
3t8oATPRhodopsin kinase/0.450
3w18N13Aurora kinase A2.7.11.10.450
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.450
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.450
5dt3ATPAurora kinase A2.7.11.10.450
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
2w1eL0EAurora kinase A2.7.11.10.449
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.449
3du8553Glycogen synthase kinase-3 beta2.7.11.260.449
3mdvCL6Cholesterol 24-hydroxylase/0.449
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.449
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.449
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.449
1ol6ATPAurora kinase A2.7.11.10.448
1yb5NAPQuinone oxidoreductase1.6.5.50.448
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.448
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.448
4af3VX6Aurora kinase B2.7.11.10.448
4e5yNDPGDP-L-fucose synthase1.1.1.2710.448
4f650S9Fibroblast growth factor receptor 1/0.448
1e3eNAIAlcohol dehydrogenase 41.1.1.10.447
1t7i017Gag-Pol polyprotein3.4.23.160.447
2j0m4STFocal adhesion kinase 12.7.10.20.447
2uxoTACHTH-type transcriptional regulator TtgR/0.447
2w1fL0FAurora kinase A2.7.11.10.447
3ttiKBIMitogen-activated protein kinase 102.7.11.240.447
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
4yryFADGlutamate synthase, beta subunit/0.447
1c6yMK1Protease/0.446
2c3qGTXGlutathione S-transferase theta-12.5.1.180.446
2vgoAD5Aurora kinase B-A2.7.11.10.446
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.446
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.446
3eljGS7Mitogen-activated protein kinase 82.7.11.240.446
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.445
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.445
2itqITQEpidermal growth factor receptor2.7.10.10.445
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.445
2vwx7X4Ephrin type-B receptor 42.7.10.10.445
2w1gL0GAurora kinase A2.7.11.10.445
3pwrROCGag-Pol polyprotein3.4.23.160.445
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.445
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.445
4nwzFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.445
5dn3ATPAurora kinase A2.7.11.10.445
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1mq4ADPAurora kinase A2.7.11.10.444
2qnqQN3Gag-Pol polyprotein3.4.23.160.444
2x9fX9FEphrin type-B receptor 42.7.10.10.444
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.444
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.443
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.443
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.443
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.443
2xvdAS6Ephrin type-B receptor 42.7.10.10.443
3kpkFADSulfide-quinone reductase/0.443
3oroAGSSerine/threonine protein kinase/0.443
3zuyTCHTransporter/0.443
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.443
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.443
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.443
4yduADPtRNA N6-adenosine threonylcarbamoyltransferase/0.443
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.442
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.442
3slkNDPPolyketide synthase extender module 2/0.442
3so9017Pol protein/0.442
4c3pACPAurora kinase A2.7.11.10.442
4c3rACPAurora kinase A2.7.11.10.442
4iaq2GM5-hydroxytryptamine receptor 1B/0.442
3pwhZMAAdenosine receptor A2a/0.442
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.441
2qak1UNGag-Pol polyprotein3.4.23.160.441
2vzmNRBCytochrome P450 monooxygenase PikC/0.441
3el4ROCGag-Pol polyprotein3.4.23.160.441
3i7eDJRGag-Pol polyprotein/0.441
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.441
3ladFADDihydrolipoyl dehydrogenase/0.441
3sm2478Putative gag-pro-pol polyprotein/0.441
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.441
4deeADPAurora kinase A2.7.11.10.441
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.441
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
2excJNKMitogen-activated protein kinase 102.7.11.240.440
2po7CHDFerrochelatase, mitochondrial4.99.1.10.440
2r3wG3GGag-Pol polyprotein3.4.23.160.440
2vwz7X6Ephrin type-B receptor 42.7.10.10.440
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.440
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.440
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.440
3l8p0CEAngiopoietin-1 receptor2.7.10.10.440
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.440
3t3c017Gag-Pol polyprotein3.4.23.160.440
4c59FEFCyclin-G-associated kinase2.7.11.10.440
4gg50J3Hepatocyte growth factor receptor2.7.10.10.440
4j5j478Gag-Pol polyprotein3.4.23.160.440
4y93746Tyrosine-protein kinase/0.440