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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.141

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1411.000
2wsbNADGalactitol dehydrogenase/0.560
2wdzNADGalactitol dehydrogenase/0.559
5jlaNADPutative short-chain dehydrogenase/reductase/0.546
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.544
3w8eNAD3-hydroxybutyrate dehydrogenase/0.537
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.536
1n5dNDPCarbonyl reductase [NADPH] 1/0.533
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.531
4yaiNAIC alpha-dehydrogenase/0.528
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.523
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.521
1wntNAPL-xylulose reductase1.1.1.100.520
1x7gNAPPutative ketoacyl reductase1.3.10.519
2dteNAIGlucose 1-dehydrogenase related protein/0.517
4yagNAIC alpha-dehydrogenase/0.517
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.515
3lqfNADGalactitol dehydrogenase/0.514
4gh5NADShort-chain dehydrogenase/reductase SDR/0.513
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.512
4j7xNAPSepiapterin reductase1.1.1.1530.512
1ae1NAPTropinone reductase 1/0.511
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.511
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.510
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.509
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.509
1pr9NAPL-xylulose reductase1.1.1.100.508
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.508
3d3wNAPL-xylulose reductase1.1.1.100.508
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.506
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.505
1iy8NADLevodione reductase/0.505
3s55NADPutative short-chain dehydrogenase/reductase/0.505
4hwkNAPSepiapterin reductase1.1.1.1530.505
5idwNAPShort-chain dehydrogenase/reductase SDR/0.504
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.503
3p19NDPPutative blue fluorescent protein/0.503
4j7uNAPSepiapterin reductase1.1.1.1530.503
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.502
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.501
2p5uNADUDP-glucose 4-epimerase/0.497
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.496
3toxNAPPutative oxidoreductase/0.496
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.496
1w4zNAPPutative ketoacyl reductase1.3.10.495
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.495
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.493
1ipeNDPTropinone reductase 21.1.1.2360.493
3qrwNDPPutative ketoacyl reductase1.3.10.492
3sx2NADUncharacterized protein/0.492
1snyNAPLD36273p/0.491
1x7hNDPPutative ketoacyl reductase1.3.10.490
3ak4NADNADH-dependent quinuclidinone reductase/0.490
3vdqNAD3-hydroxybutyrate dehydrogenase/0.490
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.490
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.489
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.488
3rj9NADAlcohol dehydrogenase1.1.1.10.488
4dc1NDPPutative ketoacyl reductase1.3.10.488
2bd0NAPSepiapterin reductase/0.487
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.487
3w8fNAD3-hydroxybutyrate dehydrogenase/0.487
5lc1NADL-threonine 3-dehydrogenase/0.487
1kvrNADUDP-glucose 4-epimerase5.1.3.20.485
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.485
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.484
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.484
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.484
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.484
3sjuNDPKeto reductase/0.482
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.482
1oaaNAPSepiapterin reductase1.1.1.1530.480
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.480
4fn4NADShort chain dehydrogenase/0.479
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.477
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.477
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.476
2yutNAPPutative short-chain oxidoreductase/0.476
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.475
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.475
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.475
1nahNADUDP-glucose 4-epimerase5.1.3.20.474
1xg5NAPDehydrogenase/reductase SDR family member 11/0.474
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.474
1mg5NAIAlcohol dehydrogenase1.1.1.10.473
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.473
3wdsNADNADH-dependent quinuclidinone reductase/0.473
3gy0NAPNAD(P)-dependent oxidoreductase/0.472
4nbwNADShort-chain dehydrogenase/reductase SDR/0.471
2jahNDPClavaldehyde dehydrogenase/0.470
3a1nNADNDP-sugar epimerase/0.470
3ggoNAIPrephenate dehydrogenase/0.470
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.470
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.469
3w8dNAD3-hydroxybutyrate dehydrogenase/0.469
5ig2NADShort-chain dehydrogenase/reductase SDR/0.469
1gcoNADGlucose 1-dehydrogenase1.1.1.470.468
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.467
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.466
5jy1NADPutative short-chain dehydrogenase/reductase/0.465
1rwbNADGlucose 1-dehydrogenase1.1.1.470.464
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.464
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.463
4esoNAPPutative oxidoreductase/0.463
5jydNADShort chain dehydrogenase/0.463
1i3lNADUDP-glucose 4-epimerase/0.462
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.462
4ej0NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.461
3a4vNADNDP-sugar epimerase/0.459
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.458
3tn7NJPShort-chain alcohol dehydrogenase/0.458
4lisNADUDP-glucose 4-epimerase (Eurofung)/0.458
1eq2NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.457
1geeNADGlucose 1-dehydrogenase1.1.1.470.457
2yy7NADL-threonine dehydrogenase/0.457
3ggpNADPrephenate dehydrogenase/0.457
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.457
1naiNADUDP-glucose 4-epimerase5.1.3.20.456
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.455
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.455
3l77NJPShort-chain alcohol dehydrogenase/0.454
1b15NAEAlcohol dehydrogenase1.1.1.10.452
3rucNADUDP-N-acetylglucosamine 4-epimerase/0.452
4o0lNDPNADPH-dependent 3-quinuclidinone reductase/0.452
1g6kNADGlucose 1-dehydrogenase1.1.1.470.451
1b16NAQAlcohol dehydrogenase1.1.1.10.450
1zemNADXylitol dehydrogenase/0.450
4bmvNAPShort-chain dehydrogenase/0.450
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.448
3ruaNADUDP-N-acetylglucosamine 4-epimerase/0.448
3tscNADUncharacterized protein/0.447
3uceNDPDehydrogenase/0.446
1xkqNDPUncharacterized protein/0.445
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.444
4qecNAPElxO/0.444
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.443
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.442
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.442
1i2bNADUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.441
3ai2NDPNADPH-sorbose reductase/0.441
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.441