scPDB - Distribution of Binding site Similarity values of 2c6l entry / Site 1

Distribution of Binding site similarity measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2c6l	DT4	Cyclin-dependent kinase 2	2.7.11.22

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
2c6l	DT4	Cyclin-dependent kinase 2	2.7.11.22	1.000
1w8c	N69	Cyclin-dependent kinase 2	2.7.11.22	0.567
2c6i	DT1	Cyclin-dependent kinase 2	2.7.11.22	0.566
2vts	LZC	Cyclin-dependent kinase 2	2.7.11.22	0.548
3lfq	A28	Cyclin-dependent kinase 2	2.7.11.22	0.533
3r83	Z14	Cyclin-dependent kinase 2	2.7.11.22	0.532
2vtp	LZ9	Cyclin-dependent kinase 2	2.7.11.22	0.525
2c6k	DT2	Cyclin-dependent kinase 2	2.7.11.22	0.521
2vto	LZ8	Cyclin-dependent kinase 2	2.7.11.22	0.520
3r8v	Z62	Cyclin-dependent kinase 2	2.7.11.22	0.520
3s1h	56Z	Cyclin-dependent kinase 2	2.7.11.22	0.519
2r3j	SCJ	Cyclin-dependent kinase 2	2.7.11.22	0.514
2r3i	SCF	Cyclin-dependent kinase 2	2.7.11.22	0.508
3r71	X86	Cyclin-dependent kinase 2	2.7.11.22	0.507
1y91	CT9	Cyclin-dependent kinase 2	2.7.11.22	0.506
2vv9	IM9	Cyclin-dependent kinase 2	2.7.11.22	0.504
2a0c	CK9	Cyclin-dependent kinase 2	2.7.11.22	0.501
1oit	HDT	Cyclin-dependent kinase 2	2.7.11.22	0.500
3rah	O1Z	Cyclin-dependent kinase 2	2.7.11.22	0.500
4fkr	45K	Cyclin-dependent kinase 2	2.7.11.22	0.500
3rak	03Z	Cyclin-dependent kinase 2	2.7.11.22	0.499
3lfn	A27	Cyclin-dependent kinase 2	2.7.11.22	0.498
3r7u	X96	Cyclin-dependent kinase 2	2.7.11.22	0.495
2uzo	C62	Cyclin-dependent kinase 2	2.7.11.22	0.492
2b53	D23	Cyclin-dependent kinase 2	2.7.11.22	0.491
2c6o	4SP	Cyclin-dependent kinase 2	2.7.11.22	0.491
2r3l	SCW	Cyclin-dependent kinase 2	2.7.11.22	0.490
3le6	2BZ	Cyclin-dependent kinase 2	2.7.11.22	0.490
1y8y	CT7	Cyclin-dependent kinase 2	2.7.11.22	0.489
1pxm	CK5	Cyclin-dependent kinase 2	2.7.11.22	0.488
3r73	X87	Cyclin-dependent kinase 2	2.7.11.22	0.487
3qx2	X63	Cyclin-dependent kinase 2	2.7.11.22	0.486
4fkl	CK2	Cyclin-dependent kinase 2	2.7.11.22	0.485
2w17	I19	Cyclin-dependent kinase 2	2.7.11.22	0.484
2c6m	DT5	Cyclin-dependent kinase 2	2.7.11.22	0.482
1pxl	CK4	Cyclin-dependent kinase 2	2.7.11.22	0.481
1pxo	CK7	Cyclin-dependent kinase 2	2.7.11.22	0.480
4fkv	61K	Cyclin-dependent kinase 2	2.7.11.22	0.480
3r7y	Z04	Cyclin-dependent kinase 2	2.7.11.22	0.479
3r9n	Z68	Cyclin-dependent kinase 2	2.7.11.22	0.479
3rpo	24Z	Cyclin-dependent kinase 2	2.7.11.22	0.479
4fks	46K	Cyclin-dependent kinase 2	2.7.11.22	0.478
1pxp	CK8	Cyclin-dependent kinase 2	2.7.11.22	0.477
3qtu	X44	Cyclin-dependent kinase 2	2.7.11.22	0.477
2w05	FRT	Cyclin-dependent kinase 2	2.7.11.22	0.476
3rk7	08Z	Cyclin-dependent kinase 2	2.7.11.22	0.476
1v1k	3FP	Cyclin-dependent kinase 2	2.7.11.22	0.475
2r3p	3SC	Cyclin-dependent kinase 2	2.7.11.22	0.475
2w06	FRV	Cyclin-dependent kinase 2	2.7.11.22	0.475
2a4l	RRC	Cyclin-dependent kinase 2	2.7.11.22	0.474
1g5s	I17	Cyclin-dependent kinase 2	2.7.11.22	0.473
1p2a	5BN	Cyclin-dependent kinase 2	2.7.11.22	0.472
1ykr	628	Cyclin-dependent kinase 2	2.7.11.22	0.471
3r8l	Z30	Cyclin-dependent kinase 2	2.7.11.22	0.470
3sw7	19K	Cyclin-dependent kinase 2	2.7.11.22	0.470
4acm	7YG	Cyclin-dependent kinase 2	2.7.11.22	0.470
2c5y	MTW	Cyclin-dependent kinase 2	2.7.11.22	0.469
3lfs	A07	Cyclin-dependent kinase 2	2.7.11.22	0.468
4qny	ANP	Mitogen activated protein kinase, putative	/	0.468
1h0w	207	Cyclin-dependent kinase 2	2.7.11.22	0.467
2r3k	SCQ	Cyclin-dependent kinase 2	2.7.11.22	0.466
3rkb	12Z	Cyclin-dependent kinase 2	2.7.11.22	0.466
3rmf	20Z	Cyclin-dependent kinase 2	2.7.11.22	0.466
2b54	D05	Cyclin-dependent kinase 2	2.7.11.22	0.465
2b52	D42	Cyclin-dependent kinase 2	2.7.11.22	0.464
2uzb	C75	Cyclin-dependent kinase 2	2.7.11.22	0.464
3qql	X03	Cyclin-dependent kinase 2	2.7.11.22	0.464
3rni	21Z	Cyclin-dependent kinase 2	2.7.11.22	0.464
2uzn	C96	Cyclin-dependent kinase 2	2.7.11.22	0.463
3wbl	PDY	Cyclin-dependent kinase 2	2.7.11.22	0.463
1fvv	107	Cyclin-dependent kinase 2	2.7.11.22	0.462
1gih	1PU	Cyclin-dependent kinase 2	2.7.11.22	0.462
3i4b	Z48	Glycogen synthase kinase-3 beta	2.7.11.26	0.462
3sqq	99Z	Cyclin-dependent kinase 2	2.7.11.22	0.462
3rai	X85	Cyclin-dependent kinase 2	2.7.11.22	0.461
3r9d	X6B	Cyclin-dependent kinase 2	2.7.11.22	0.460
1oir	HDY	Cyclin-dependent kinase 2	2.7.11.22	0.459
4bgh	3I6	Cyclin-dependent kinase 2	2.7.11.22	0.459
4fko	20K	Cyclin-dependent kinase 2	2.7.11.22	0.459
2vtt	LZD	Cyclin-dependent kinase 2	2.7.11.22	0.458
4ek8	16K	Cyclin-dependent kinase 2	2.7.11.22	0.458
1gii	1PU	Cyclin-dependent kinase 2	2.7.11.22	0.457
3ezr	EZR	Cyclin-dependent kinase 2	2.7.11.22	0.457
2bhh	RYU	Cyclin-dependent kinase 2	2.7.11.22	0.455
2ds1	1CD	Cyclin-dependent kinase 2	2.7.11.22	0.455
3ggf	GVD	Serine/threonine-protein kinase 26	/	0.455
3qtx	X43	Cyclin-dependent kinase 2	2.7.11.22	0.455
3qxo	X65	Cyclin-dependent kinase 2	2.7.11.22	0.455
2r3f	SC8	Cyclin-dependent kinase 2	2.7.11.22	0.454
3ezv	EZV	Cyclin-dependent kinase 2	2.7.11.22	0.454
1pxj	CK2	Cyclin-dependent kinase 2	2.7.11.22	0.453
2r64	740	Cyclin-dependent kinase 2	2.7.11.22	0.453
4fkq	42K	Cyclin-dependent kinase 2	2.7.11.22	0.453
4erw	STU	Cyclin-dependent kinase 2	2.7.11.22	0.452
1pye	PM1	Cyclin-dependent kinase 2	2.7.11.22	0.451
2vtq	LZA	Cyclin-dependent kinase 2	2.7.11.22	0.451
3fz1	B98	Cyclin-dependent kinase 2	2.7.11.22	0.451
3r7v	Z02	Cyclin-dependent kinase 2	2.7.11.22	0.451
4aqc	88A	Tyrosine-protein kinase JAK2	/	0.451
1aq1	STU	Cyclin-dependent kinase 2	2.7.11.22	0.450
2xmy	CDK	Cyclin-dependent kinase 2	2.7.11.22	0.450
3hmm	855	TGF-beta receptor type-1	2.7.11.30	0.450
2r3r	6SC	Cyclin-dependent kinase 2	2.7.11.22	0.449
3f69	XDR	Serine/threonine-protein kinase PknB	2.7.11.1	0.448
2r3g	SC9	Cyclin-dependent kinase 2	2.7.11.22	0.447
4fkw	62K	Cyclin-dependent kinase 2	2.7.11.22	0.447
4oh4	ANP	Protein BRASSINOSTEROID INSENSITIVE 1	2.7.10.1	0.447
1ke7	LS3	Cyclin-dependent kinase 2	2.7.11.22	0.446
2w1h	L0F	Cyclin-dependent kinase 2	2.7.11.22	0.446
2pvm	P29	Casein kinase II subunit alpha	2.7.11.1	0.445
3qzh	X69	Cyclin-dependent kinase 2	2.7.11.22	0.445
3ral	04Z	Cyclin-dependent kinase 2	2.7.11.22	0.445
3roy	22Z	Cyclin-dependent kinase 2	2.7.11.22	0.445
4fg9	ATP	Calcium/calmodulin-dependent protein kinase type 1	2.7.11.17	0.445
4hge	15V	Tyrosine-protein kinase JAK2	/	0.445
1e1x	NW1	Cyclin-dependent kinase 2	2.7.11.22	0.444
1oiq	HDU	Cyclin-dependent kinase 2	2.7.11.22	0.444
1h1s	4SP	Cyclin-dependent kinase 2	2.7.11.22	0.443
2b55	D31	Cyclin-dependent kinase 2	2.7.11.22	0.443
3ddp	RC8	Cyclin-dependent kinase 2	2.7.11.22	0.443
4j95	ACP	Fibroblast growth factor receptor 2	/	0.443
3qtr	X36	Cyclin-dependent kinase 2	2.7.11.22	0.442
4anm	WUL	Casein kinase II subunit alpha	2.7.11.1	0.442
1hck	ATP	Cyclin-dependent kinase 2	2.7.11.22	0.441
2c6t	DT5	Cyclin-dependent kinase 2	2.7.11.22	0.441
2r3q	5SC	Cyclin-dependent kinase 2	2.7.11.22	0.441
3sw4	18K	Cyclin-dependent kinase 2	2.7.11.22	0.441
4btj	ADP	Tau-tubulin kinase 1	2.7.11.1	0.441
2r3m	SCX	Cyclin-dependent kinase 2	2.7.11.22	0.440
3llt	ANP	Protein serine/threonine kinase-1	/	0.440
3rpv	26Z	Cyclin-dependent kinase 2	2.7.11.22	0.440