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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2b7aIZATyrosine-protein kinase JAK2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2b7aIZATyrosine-protein kinase JAK2/1.000
4aqc88ATyrosine-protein kinase JAK2/0.563
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.555
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.536
3lxpIZANon-receptor tyrosine-protein kinase TYK22.7.10.20.524
4ji91M3Tyrosine-protein kinase JAK2/0.520
3lpbNVBTyrosine-protein kinase JAK2/0.512
2xa4AZ5Tyrosine-protein kinase JAK2/0.510
3iok1P6Tyrosine-protein kinase JAK2/0.508
4hge15VTyrosine-protein kinase JAK2/0.497
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.496
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.493
3eyhIZATyrosine-protein kinase JAK1/0.490
3s1h56ZCyclin-dependent kinase 22.7.11.220.489
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.488
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.488
3r83Z14Cyclin-dependent kinase 22.7.11.220.486
3zmmF9JTyrosine-protein kinase JAK2/0.485
4qmpDKISerine/threonine-protein kinase 242.7.11.10.483
4iva1J5Tyrosine-protein kinase JAK2/0.480
1qrpHH0Pepsin A-43.4.23.10.479
3rvg17PTyrosine-protein kinase JAK2/0.479
3zep1NXTyrosine-protein kinase JAK32.7.10.20.479
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.477
4dgnLU2Casein kinase II subunit alpha2.7.11.10.477
3be9P04Casein kinase II subunit alpha2.7.11.10.475
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.475
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.472
4gmy0X5Tyrosine-protein kinase JAK2/0.471
4c61LMMTyrosine-protein kinase JAK2/0.469
4e4m0NHTyrosine-protein kinase JAK2/0.468
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.467
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.466
3rmf20ZCyclin-dependent kinase 22.7.11.220.466
4k771Q4Tyrosine-protein kinase JAK1/0.466
4yryFADGlutamate synthase, beta subunit/0.466
1me6IVSPlasmepsin-23.4.23.390.465
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.465
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.465
2xikJ60Serine/threonine-protein kinase 252.7.11.10.463
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.463
4ambDUDPutative glycosyl transferase/0.463
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.463
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.462
4acm7YGCyclin-dependent kinase 22.7.11.220.462
2pvhP19Casein kinase II subunit alpha2.7.11.10.461
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.460
2xx91NFGlutamate receptor 2/0.460
5e8ySTUTGF-beta receptor type-22.7.11.300.460
1e3eNAIAlcohol dehydrogenase 41.1.1.10.459
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.459
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.458
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.458
4iwd1JCHepatocyte growth factor receptor2.7.10.10.458
5e8wSTUTGF-beta receptor type-12.7.11.300.458
1om1IQACasein kinase II subunit alpha2.7.11.10.457
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.455
2x1nX1NCyclin-dependent kinase 22.7.11.220.455
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.455
1m2rMNYCasein kinase II subunit alpha2.7.11.10.454
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.454
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.454
2b53D23Cyclin-dependent kinase 22.7.11.220.453
4jia1K3Tyrosine-protein kinase JAK2/0.453
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.452
4bbfO19Tyrosine-protein kinase JAK2/0.452
4fv6E57Mitogen-activated protein kinase 12.7.11.240.452
4ivc1J6Tyrosine-protein kinase JAK1/0.452
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.452
1qorNDPQuinone oxidoreductase 1/0.451
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.451
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.451
2iw84SPCyclin-dependent kinase 22.7.11.220.450
3oqkS52Renin3.4.23.150.450
4a6cQG9Gag-Pol polyprotein3.4.23.160.450
1g5sI17Cyclin-dependent kinase 22.7.11.220.449
1w6hTITPlasmepsin-23.4.23.390.449
2pvnP63Casein kinase II subunit alpha2.7.11.10.449
3ggfGVDSerine/threonine-protein kinase 26/0.449
3slkNDPPolyketide synthase extender module 2/0.449
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.448
3gw9VNILanosterol 14-alpha-demethylase/0.448
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.448
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.448
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.447
3bbrBHYGlutamate receptor 2/0.447
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.447
3zlx5EZDual specificity mitogen-activated protein kinase kinase 12.7.12.20.447
4a6bQG8Gag-Pol polyprotein3.4.23.160.447
1h1r6CPCyclin-dependent kinase 22.7.11.220.446
1h1s4SPCyclin-dependent kinase 22.7.11.220.446
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.446
1vikBAYGag-Pol polyprotein/0.446
2iw94SPCyclin-dependent kinase 22.7.11.220.446
2yexYEXSerine/threonine-protein kinase Chk12.7.11.10.446
3raiX85Cyclin-dependent kinase 22.7.11.220.446
4a4qUX9Pol protein/0.446
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.446
1lf3EH5Plasmepsin-23.4.23.390.445
2g247IGRenin3.4.23.150.445
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.445
4fod0UVALK tyrosine kinase receptor2.7.10.10.445
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.445
4wsqKSAAP2-associated protein kinase 12.7.11.10.445
5jscFADPutative acyl-CoA dehydrogenase/0.445
1eh4IC1Casein kinase I homolog 12.7.11.10.444
1jipKTN6-deoxyerythronolide B hydroxylase/0.444
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.444
2ikuLIYRenin3.4.23.150.444
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.444
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.444
3uli1N3Cyclin-dependent kinase 22.7.11.220.444
3wblPDYCyclin-dependent kinase 22.7.11.220.444
4frkDWDBeta-secretase 13.4.23.460.444
1oirHDYCyclin-dependent kinase 22.7.11.220.443
1oiyN41Cyclin-dependent kinase 22.7.11.220.443
2vttLZDCyclin-dependent kinase 22.7.11.220.443
4f081RSTyrosine-protein kinase JAK2/0.443
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.443
1aq1STUCyclin-dependent kinase 22.7.11.220.442
1k6tXN1Gag-Pol polyprotein3.4.23.160.442
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.442
2w06FRVCyclin-dependent kinase 22.7.11.220.442
3gxlQIGTGF-beta receptor type-12.7.11.300.442
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.442
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.442
4ivb1J5Tyrosine-protein kinase JAK1/0.442
1c70L75Protease/0.441
1pxmCK5Cyclin-dependent kinase 22.7.11.220.441
2c6tDT5Cyclin-dependent kinase 22.7.11.220.441
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.441
3lxkMI1Tyrosine-protein kinase JAK32.7.10.20.441
4fkr45KCyclin-dependent kinase 22.7.11.220.441
2wxvWXVCyclin-dependent kinase 22.7.11.220.440
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.440