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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.11.000
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.570
4xlvACPInsulin receptor2.7.10.10.526
3c4zADPRhodopsin kinase/0.497
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.488
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.486
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.485
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.485
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.484
4qnyANPMitogen activated protein kinase, putative/0.483
3bu5ATPInsulin receptor2.7.10.10.482
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.481
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.479
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.479
1u54ACPActivated CDC42 kinase 1/0.476
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.476
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.476
4ysjADPCalmodulin-like domain protein kinase/0.474
3c4wATPRhodopsin kinase/0.473
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.470
3t8oATPRhodopsin kinase/0.469
1ig1ANPDeath-associated protein kinase 12.7.11.10.468
4deeADPAurora kinase A2.7.11.10.468
1dayGNPCasein kinase II subunit alpha2.7.11.10.467
2w4jADPDeath-associated protein kinase 12.7.11.10.467
3gu7ADPDeath-associated protein kinase 12.7.11.10.467
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.463
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.463
3c50ADPRhodopsin kinase/0.462
3zxtACPDeath-associated protein kinase 12.7.11.10.462
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.462
3qc9ADPRhodopsin kinase/0.457
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.457
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.456
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.456
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.456
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.456
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.456
3nszANPCasein kinase II subunit alpha2.7.11.10.455
4eooATPCyclin-dependent kinase 22.7.11.220.455
5dnrATPAurora kinase A2.7.11.10.455
4i3zADPCyclin-dependent kinase 22.7.11.220.454
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.453
1phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.452
2izrBRKCasein kinase I isoform gamma-32.7.11.10.451
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.451
4hvi19STyrosine-protein kinase JAK32.7.10.20.451
1dawANPCasein kinase II subunit alpha2.7.11.10.450
1ir3ANPInsulin receptor2.7.10.10.450
2etm7PYFocal adhesion kinase 12.7.10.20.450
3c4xATPRhodopsin kinase/0.450
4k33ACPFibroblast growth factor receptor 32.7.10.10.450
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.449
4ic7ANPMitogen-activated protein kinase 72.7.11.240.449
2j0m4STFocal adhesion kinase 12.7.10.20.448
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.448
3gu5ANPDeath-associated protein kinase 12.7.11.10.448
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.448
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.447
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.447
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.447
4hge15VTyrosine-protein kinase JAK2/0.447
1qmzATPCyclin-dependent kinase 22.7.11.220.445
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.445
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.445
4jrnANPRhoptry kinase family protein/0.444
4lfiGNPCasein kinase II subunit alpha2.7.11.10.444
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.444
1ol7ADPAurora kinase A2.7.11.10.442
1pkdUCNCyclin-dependent kinase 22.7.11.220.442
1pmn984Mitogen-activated protein kinase 102.7.11.240.442
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.442
1wvxBD4Death-associated protein kinase 12.7.11.10.441
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.441
2hog710Serine/threonine-protein kinase Chk12.7.11.10.441
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.441
4fv6E57Mitogen-activated protein kinase 12.7.11.240.441
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.440
1yvj4STTyrosine-protein kinase JAK32.7.10.20.440
2ckeIQUDeath-associated protein kinase 2/0.440
2uzbC75Cyclin-dependent kinase 22.7.11.220.440
3a7jADPSerine/threonine-protein kinase 242.7.11.10.440