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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1x7hNDPPutative ketoacyl reductase1.3.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1x7hNDPPutative ketoacyl reductase1.3.11.000
3qrwNDPPutative ketoacyl reductase1.3.10.620
1x7gNAPPutative ketoacyl reductase1.3.10.602
1w4zNAPPutative ketoacyl reductase1.3.10.598
4dc1NDPPutative ketoacyl reductase1.3.10.581
3sjuNDPKeto reductase/0.580
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.577
1ae1NAPTropinone reductase 1/0.564
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.561
3p19NDPPutative blue fluorescent protein/0.559
1n5dNDPCarbonyl reductase [NADPH] 1/0.538
5jlaNADPutative short-chain dehydrogenase/reductase/0.532
3l77NJPShort-chain alcohol dehydrogenase/0.529
1ipeNDPTropinone reductase 21.1.1.2360.528
3toxNAPPutative oxidoreductase/0.528
4hwkNAPSepiapterin reductase1.1.1.1530.528
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.527
1xg5NAPDehydrogenase/reductase SDR family member 11/0.526
1g6kNADGlucose 1-dehydrogenase1.1.1.470.524
4j7xNAPSepiapterin reductase1.1.1.1530.522
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.521
3f1kNAPUncharacterized oxidoreductase YciK10.518
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.518
4j7uNAPSepiapterin reductase1.1.1.1530.511
2wdzNADGalactitol dehydrogenase/0.510
3tn7NJPShort-chain alcohol dehydrogenase/0.510
1pr9NAPL-xylulose reductase1.1.1.100.509
2bd0NAPSepiapterin reductase/0.509
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.509
4qecNAPElxO/0.509
1xkqNDPUncharacterized protein/0.507
1gcoNADGlucose 1-dehydrogenase1.1.1.470.506
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.506
1geeNADGlucose 1-dehydrogenase1.1.1.470.505
1wntNAPL-xylulose reductase1.1.1.100.505
2yutNAPPutative short-chain oxidoreductase/0.504
3gy0NAPNAD(P)-dependent oxidoreductase/0.504
3lqfNADGalactitol dehydrogenase/0.504
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.503
1oaaNAPSepiapterin reductase1.1.1.1530.501
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.499
3w8eNAD3-hydroxybutyrate dehydrogenase/0.499
1rwbNADGlucose 1-dehydrogenase1.1.1.470.497
1snyNAPLD36273p/0.497
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.497
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.496
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.496
4bmvNAPShort-chain dehydrogenase/0.495
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.495
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.494
5idwNAPShort-chain dehydrogenase/reductase SDR/0.494
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.493
3ai2NDPNADPH-sorbose reductase/0.492
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.490
4o0lNDPNADPH-dependent 3-quinuclidinone reductase/0.488
4qedNAPElxO/0.488
3vdqNAD3-hydroxybutyrate dehydrogenase/0.487
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.487
3u4cNDPNADPH-dependent reductase BacG/0.486
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.486
4yaiNAIC alpha-dehydrogenase/0.485
2dteNAIGlucose 1-dehydrogenase related protein/0.483
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.483
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.481
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.479
3wdsNADNADH-dependent quinuclidinone reductase/0.479
2wsbNADGalactitol dehydrogenase/0.477
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.477
3w8dNAD3-hydroxybutyrate dehydrogenase/0.475
4esoNAPPutative oxidoreductase/0.475
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.475
1b16NAQAlcohol dehydrogenase1.1.1.10.474
2jahNDPClavaldehyde dehydrogenase/0.472
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.472
3d3wNAPL-xylulose reductase1.1.1.100.472
4gh5NADShort-chain dehydrogenase/reductase SDR/0.472
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.471
1zemNADXylitol dehydrogenase/0.470
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.470
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.469
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.468
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.468
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.468
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.467
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.465
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.465
3uxyNADShort-chain dehydrogenase/reductase SDR/0.465
3w8fNAD3-hydroxybutyrate dehydrogenase/0.465
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.464
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.463
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.461
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.461
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.461
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.460
3ai3NDPNADPH-sorbose reductase/0.460
4dbzNDPPutative ketoacyl reductase1.3.10.460
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.459
4pvdNDPNADPH-dependent methylglyoxal reductase GRE2/0.459
3ak4NADNADH-dependent quinuclidinone reductase/0.458
5lc1NADL-threonine 3-dehydrogenase/0.458
4yagNAIC alpha-dehydrogenase/0.456
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.455
1iy8NADLevodione reductase/0.453
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.453
1b15NAEAlcohol dehydrogenase1.1.1.10.452
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.452
2gn8NAPUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.450
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.448
4dc0NDPPutative ketoacyl reductase1.3.10.448
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.447
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.447
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.446
1mg5NAIAlcohol dehydrogenase1.1.1.10.445
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.445
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.444
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
3pefNAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase/0.443
4nbwNADShort-chain dehydrogenase/reductase SDR/0.442
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.441
3rj9NADAlcohol dehydrogenase1.1.1.10.441