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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1qf5RPLAdenylosuccinate synthetase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1qf5RPLAdenylosuccinate synthetase/1.000
1qf4RPDAdenylosuccinate synthetase/0.811
1cg1IMOAdenylosuccinate synthetase/0.609
1kszPGSAdenylosuccinate synthetase/0.594
1cg3IMOAdenylosuccinate synthetase/0.587
1cg4IMOAdenylosuccinate synthetase/0.584
1cg0IMOAdenylosuccinate synthetase/0.575
1nhtPGSAdenylosuccinate synthetase/0.559
2dgnDOIAdenylosuccinate synthetase isozyme 1/0.557
1lonIMOAdenylosuccinate synthetase isozyme 1/0.552
1p9bIMOAdenylosuccinate synthetase/0.542
2gcqDOIAdenylosuccinate synthetase/0.532
4ji91M3Tyrosine-protein kinase JAK2/0.473
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.467
2b7aIZATyrosine-protein kinase JAK2/0.465
3r95ACOMccE protein/0.463
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.459
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.459
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.459
1f0xFADD-lactate dehydrogenase1.1.1.280.455
2a92NAIL-lactate dehydrogenase/0.454
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.454
4ambDUDPutative glycosyl transferase/0.454
5dp2NAPCurF/0.454
4aqc88ATyrosine-protein kinase JAK2/0.453
2q4bNAPUncharacterized protein At5g02240/0.451
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.450
4bfxZVXPantothenate kinase2.7.1.330.450
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.449
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.449
3qlsNDPDihydrofolate reductase1.5.1.30.449
4jlj1NMDeoxycytidine kinase2.7.1.740.448
4h4uFADBiphenyl dioxygenase ferredoxin reductase subunit/0.447
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.447
1mp0NADAlcohol dehydrogenase class-31.1.1.10.446
1rx1NAPDihydrofolate reductase1.5.1.30.446
2c29NAPDihydroflavonol 4-reductase/0.446
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.446
3d3wNAPL-xylulose reductase1.1.1.100.446
3mjhGTPRas-related protein Rab-5A/0.446
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.446
4an4DUDPutative glycosyl transferase/0.445
2c27ACOMycothiol acetyltransferase2.3.1.1890.444
2v6gNAP3-oxo-Delta(4,5)-steroid 5-beta-reductase/0.444
3r3sNADPutative oxidoreductase/0.444
4eudCOASuccinyl-CoA:acetate CoA-transferase/0.444
3zh8C58Protein kinase C iota type2.7.11.130.443
4yjdFADD-amino-acid oxidase1.4.3.30.443
4g7gVFVLanosterol 14-alpha-demethylase/0.442
3gw9VNILanosterol 14-alpha-demethylase/0.441
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.441
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.441
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.441
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.440