sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1ove | 358 | Mitogen-activated protein kinase 14 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1ove | 358 | Mitogen-activated protein kinase 14 | / | 1.000 | |
| 3gc7 | B45 | Mitogen-activated protein kinase 14 | / | 0.589 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.589 | |
| 3hub | 469 | Mitogen-activated protein kinase 14 | / | 0.568 | |
| 3fl4 | FL4 | Mitogen-activated protein kinase 14 | / | 0.556 | |
| 3fkn | FKN | Mitogen-activated protein kinase 14 | / | 0.543 | |
| 1ouy | 094 | Mitogen-activated protein kinase 14 | / | 0.540 | |
| 3gc8 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.540 | |
| 3fko | FKO | Mitogen-activated protein kinase 14 | / | 0.538 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.534 | |
| 1zzl | TZY | Mitogen-activated protein kinase 14 | / | 0.528 | |
| 1m7q | DQO | Mitogen-activated protein kinase 14 | / | 0.525 | |
| 2gfs | PQB | Mitogen-activated protein kinase 14 | / | 0.523 | |
| 1ouk | 084 | Mitogen-activated protein kinase 14 | / | 0.520 | |
| 3fc1 | 52P | Mitogen-activated protein kinase 14 | / | 0.516 | |
| 3itz | P66 | Mitogen-activated protein kinase 14 | / | 0.512 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.507 | |
| 3fmm | XI2 | Mitogen-activated protein kinase 14 | / | 0.499 | |
| 1w7h | 3IP | Mitogen-activated protein kinase 14 | / | 0.497 | |
| 2yix | YIX | Mitogen-activated protein kinase 14 | / | 0.497 | |
| 3kf7 | L9G | Mitogen-activated protein kinase 14 | / | 0.497 | |
| 1zyj | BI5 | Mitogen-activated protein kinase 14 | / | 0.494 | |
| 3fls | FLS | Mitogen-activated protein kinase 14 | / | 0.493 | |
| 3hp5 | 52P | Mitogen-activated protein kinase 14 | / | 0.491 | |
| 3s4q | NK0 | Mitogen-activated protein kinase 14 | / | 0.491 | |
| 3uvq | FS8 | Mitogen-activated protein kinase 14 | / | 0.487 | |
| 3flq | 891 | Mitogen-activated protein kinase 14 | / | 0.486 | |
| 3hll | I45 | Mitogen-activated protein kinase 14 | / | 0.486 | |
| 3mvl | 38P | Mitogen-activated protein kinase 14 | / | 0.486 | |
| 3w33 | W19 | Epidermal growth factor receptor | 2.7.10.1 | 0.484 | |
| 1ywr | LI9 | Mitogen-activated protein kinase 14 | / | 0.482 | |
| 3roc | 29A | Mitogen-activated protein kinase 14 | / | 0.481 | |
| 3e92 | G6A | Mitogen-activated protein kinase 14 | / | 0.479 | |
| 2z4z | SC0 | Geranylgeranyl pyrophosphate synthase | / | 0.478 | |
| 1yw2 | PGJ | Mitogen-activated protein kinase 14 | / | 0.476 | |
| 3uvp | 048 | Mitogen-activated protein kinase 14 | / | 0.476 | |
| 3d5q | T30 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.475 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.474 | |
| 2itz | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.473 | |
| 2k62 | ITL | Fatty acid-binding protein, liver | / | 0.473 | |
| 3iw5 | DF3 | Mitogen-activated protein kinase 14 | / | 0.471 | |
| 3obg | SB2 | Mitogen-activated protein kinase 14 | / | 0.471 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.469 | |
| 3mpa | SB2 | Mitogen-activated protein kinase 14 | / | 0.468 | |
| 4eh9 | IRG | Mitogen-activated protein kinase 14 | / | 0.468 | |
| 4ewq | MWL | Mitogen-activated protein kinase 14 | / | 0.468 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.467 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.467 | |
| 3cjg | KIM | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.467 | |
| 4dlj | 6RG | Mitogen-activated protein kinase 14 | / | 0.467 | |
| 3rin | I2O | Mitogen-activated protein kinase 14 | / | 0.466 | |
| 4gk4 | L90 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.466 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.465 | |
| 2xsz | ATP | RuvB-like 2 | 3.6.4.12 | 0.465 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.465 | |
| 3zsi | 52P | Mitogen-activated protein kinase 14 | / | 0.465 | |
| 4xxv | NAD | 3-isopropylmalate dehydrogenase | / | 0.465 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.464 | |
| 3flw | FLW | Mitogen-activated protein kinase 14 | / | 0.464 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.464 | |
| 3p6p | A6B | Camphor 5-monooxygenase | 1.14.15.1 | 0.464 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.464 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.463 | |
| 3iw6 | PP0 | Mitogen-activated protein kinase 14 | / | 0.463 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.463 | |
| 4f64 | 0S8 | Fibroblast growth factor receptor 1 | / | 0.463 | |
| 2z4w | 749 | Geranylgeranyl pyrophosphate synthase | / | 0.461 | |
| 2zb0 | GK3 | Mitogen-activated protein kinase 14 | / | 0.461 | |
| 3dt1 | P40 | Mitogen-activated protein kinase 14 | / | 0.461 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.461 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.461 | |
| 3fmn | 530 | Mitogen-activated protein kinase 14 | / | 0.460 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.460 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.460 | |
| 4mxx | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.460 | |
| 3gfe | P37 | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 3iph | G11 | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.459 | |
| 1bl6 | SB6 | Mitogen-activated protein kinase 14 | / | 0.458 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 1syn | F89 | Thymidylate synthase | / | 0.458 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.458 | |
| 3ml9 | ML9 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 4bgb | ADP | Predicted molecular chaperone distantly related to HSP70-fold metalloproteases | / | 0.457 | |
| 2i0e | PDS | Protein kinase C beta type | 2.7.11.13 | 0.456 | |
| 2itp | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.456 | |
| 2itt | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.456 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.456 | |
| 3new | 3NE | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.455 | |
| 4f63 | 0S7 | Fibroblast growth factor receptor 1 | / | 0.455 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.454 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 2brm | DFZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.454 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.454 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.454 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.454 | |
| 4nfn | 2KC | Tau-tubulin kinase 1 | 2.7.11.1 | 0.454 | |
| 2gtn | LIE | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 2zaz | GK1 | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 3uib | SB2 | Putative mitogen-activated protein kinase | / | 0.453 | |
| 4gkh | 0J9 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.453 | |
| 1i9c | 5AD | Glutamate mutase epsilon subunit | / | 0.452 | |
| 1sej | F89 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.452 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.452 | |
| 2pvy | ACP | Fibroblast growth factor receptor 2 | / | 0.452 | |
| 3bv2 | P38 | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.452 | |
| 4j97 | ACP | Fibroblast growth factor receptor 2 | / | 0.452 | |
| 4nks | 2M2 | Fibroblast growth factor receptor 1 | / | 0.452 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.451 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 2zym | ACX | Periplasmic binding protein | / | 0.451 | |
| 3fml | FML | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.451 | |
| 4nka | 2K7 | Fibroblast growth factor receptor 1 | / | 0.451 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 2e99 | B08 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.450 | |
| 2giu | FBR | Estrogen receptor beta | / | 0.450 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.450 | |
| 3c5u | P41 | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 3fkl | FKL | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.450 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.450 | |
| 1yin | CM3 | Estrogen receptor | / | 0.449 | |
| 2dq7 | STU | Tyrosine-protein kinase Fyn | 2.7.10.2 | 0.449 | |
| 3bx5 | 304 | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 4hvb | 19P | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 1e8z | STU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 1v9a | SAH | Uncharacterized protein | / | 0.448 | |
| 1wbw | LI4 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3iw8 | HIZ | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.448 | |
| 4bc6 | XZN | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.448 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.448 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.448 | |
| 4qmn | DB8 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.448 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.448 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.448 | |
| 5dc5 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.448 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.447 | |
| 3fln | 3FN | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 3fsk | RO6 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 3nww | 3NW | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.447 | |
| 3uku | C69 | Actin-related protein 3 | / | 0.447 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.447 | |
| 4aac | AAV | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 4ans | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.447 | |
| 4hgl | 0YO | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.447 | |
| 4jrv | KJV | Epidermal growth factor receptor | 2.7.10.1 | 0.447 | |
| 4mxo | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.447 | |
| 1re9 | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.446 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
| 4twp | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.446 | |
| 1lri | CLR | Beta-elicitin cryptogein | / | 0.445 | |
| 1yqj | 6NP | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 2a7r | 5GP | GMP reductase 2 | / | 0.445 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.445 | |
| 3ule | C69 | Actin-related protein 3 | / | 0.445 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.445 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.445 | |
| 1m17 | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.444 | |
| 1qpj | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.444 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1uml | FR4 | Adenosine deaminase | 3.5.4.4 | 0.443 | |
| 3a4o | STU | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.443 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.443 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.443 | |
| 4fhj | 0TZ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.443 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.443 | |
| 4kao | KAO | Focal adhesion kinase 1 | 2.7.10.2 | 0.443 | |
| 1fml | RTL | Retinol dehydratase | / | 0.442 | |
| 1nbm | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.442 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 2qe4 | JJ3 | Estrogen receptor | / | 0.442 | |
| 2zb1 | GK4 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.442 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.442 | |
| 3mvm | 39P | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3p6n | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.442 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.442 | |
| 4eh6 | 0ON | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.442 | |
| 4jq8 | KJ8 | Epidermal growth factor receptor | 2.7.10.1 | 0.442 | |
| 4nk9 | 2K5 | Fibroblast growth factor receptor 1 | / | 0.442 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.442 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.442 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 1xp6 | AIU | Estrogen receptor | / | 0.441 | |
| 1y57 | MPZ | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.441 | |
| 2x7g | PVB | SRSF protein kinase 2 | 2.7.11.1 | 0.441 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.441 | |
| 3d8v | UD1 | Bifunctional protein GlmU | / | 0.441 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.441 | |
| 3h6k | 33T | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 3hl7 | I47 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3lj3 | WYE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.441 | |
| 4h1j | 0YH | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.441 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.441 | |
| 4l9q | 9TP | Serum albumin | / | 0.441 | |
| 5dcy | NAP | Iridoid synthase | 1.3.1.99 | 0.441 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 2gtm | LID | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 4bid | IE8 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.440 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4eh7 | 0OO | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.440 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.440 | |
| 4g2g | TDH | Mycocyclosin synthase | 1.14.21.9 | 0.440 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.440 |