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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1o94ADPTrimethylamine dehydrogenase1.5.8.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1o94ADPTrimethylamine dehydrogenase1.5.8.21.000
1djqADPTrimethylamine dehydrogenase1.5.8.20.667
2tmdADPTrimethylamine dehydrogenase1.5.8.20.659
1djnADPTrimethylamine dehydrogenase1.5.8.20.658
1u7hNADPutative ornithine cyclodeaminase/0.521
1w4xFADPhenylacetone monooxygenase1.14.13.920.519
2ym2FADPhenylacetone monooxygenase1.14.13.920.515
3fpzAHZThiamine thiazole synthase/0.511
2ylsFADPhenylacetone monooxygenase1.14.13.920.502
3cgeFADCoenzyme A disulfide reductase/0.500
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.497
4opiFDAConserved Archaeal protein/0.496
4u8iFDAUDP-galactopyranose mutase/0.492
2zz0FADThioredoxin reductase 1, cytoplasmic1.8.1.90.489
2gr2APRFerredoxin reductase/0.488
2gr0ADPFerredoxin reductase/0.487
3djgFADGlutathione reductase, mitochondrial1.8.1.70.485
1gthFADDihydropyrimidine dehydrogenase [NADP(+)]1.3.1.20.484
3djjFADGlutathione reductase, mitochondrial1.8.1.70.484
3qv1NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic1.2.1.130.483
3uoxFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.482
4d03FADPhenylacetone monooxygenase1.14.13.920.482
2yr4FADPhenylalanine 2-monooxygenase precursor1.13.12.90.481
1x7dNADPutative ornithine cyclodeaminase/0.480
2ylzFADPhenylacetone monooxygenase1.14.13.920.480
2bryFAD[F-actin]-methionine sulfoxide oxidase MICAL11.14.130.479
2ylxFADPhenylacetone monooxygenase1.14.13.920.479
1gesFADGlutathione reductase1.8.1.70.478
4b69FADL-ornithine N(5)-monooxygenase/0.478
4opgFDAConserved Archaeal protein/0.476
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.475
2yr5FADPhenylalanine 2-monooxygenase precursor1.13.12.90.475
2zzcFADThioredoxin reductase 1, cytoplasmic1.8.1.90.474
2rabFADGlutathione amide reductase/0.472
4pvdNDPNADPH-dependent methylglyoxal reductase GRE2/0.470
4bk3FADProbable salicylate monooxygenase/0.469
3up5FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.467
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.466
1geuFADGlutathione reductase1.8.1.70.465
4y9qC2EUncharacterized protein/0.465
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.463
4obwSAM2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial/0.463
3wv7ADPHmd co-occurring protein HcgE/0.462
4u2tFADCholesterol oxidase1.1.3.60.462
4bbyFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.461
4ntdFADThioredoxin reductase/0.461
4x9nFADUncharacterized protein MG039 homolog/0.461
1xe55FEPlasmepsin-23.4.23.390.460
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
3k30ADPHistamine dehydrogenase/0.460
4o8aFADBifunctional protein PutA1.2.1.880.460
1hbvGANGag-Pol polyprotein/0.459
4s26SAHPhosphomethylpyrimidine synthase, chloroplastic4.1.99.170.459
3sj7NDP3-oxoacyl-(Acyl-carrier-protein) reductase, putative/0.458
1u3cFADCryptochrome-1/0.457
1xddAAYIntegrin alpha-L/0.457
3nlcFADUncharacterized protein/0.457
3dghFADThioredoxin reductase 1, mitochondrial1.8.1.90.456
1getFADGlutathione reductase1.8.1.70.455
2vhxNADAlanine dehydrogenase1.4.1.10.455
3ad9NADSubunit alpha of sarocosine oxidase/0.455
3gwdFADCyclohexanone monooxygenase/0.455
4lxa1YSBeta-secretase 13.4.23.460.455
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
2iqgF2IBeta-secretase 13.4.23.460.454
3qbhQBHBeta-secretase 13.4.23.460.454
2gciMRRProbable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )/0.453
4b8wNAPGDP-L-fucose synthase1.1.1.2710.453
2fznFADBifunctional protein PutA1.5.5.20.452
4tlxFDAKtzI/0.452
1e1lFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.451
3elySAHMethyltransferase/0.451
3lpkZ76Beta-secretase 13.4.23.460.451
4yryFADGlutamate synthase, beta subunit/0.451
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.450
2o23NAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.450
1k6vXN2Gag-Pol polyprotein3.4.23.160.449
1w2xRCPAcetyl-CoA carboxylase/0.449
2cvjFADThioredoxin reductase related protein/0.449
3adaNADSubunit alpha of sarocosine oxidase/0.449
3e8nVRADual specificity mitogen-activated protein kinase kinase 12.7.12.20.449
3f8rNAPNADH oxidase/thioredoxin reductase/0.449
3lpiZ74Beta-secretase 13.4.23.460.449
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.449
4i6aHMG3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.449
5idwNAPShort-chain dehydrogenase/reductase SDR/0.449
2q0lFADThioredoxin reductase1.8.1.90.448
3e2sFADBifunctional protein PutA1.5.5.20.448
3kjiADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.448
1rp0AHZThiamine thiazole synthase, chloroplastic/0.447
3f8pNADNADH oxidase/thioredoxin reductase/0.447
3fg2FADPutative rubredoxin reductase/0.447
3s5wFADL-ornithine N(5)-monooxygenase/0.447
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.446
3isjA8DPantothenate synthetase6.3.2.10.446
3nn6FB06-hydroxy-L-nicotine oxidase/0.446
4b8zNAPGDP-L-fucose synthase1.1.1.2710.446
1k6tXN1Gag-Pol polyprotein3.4.23.160.445
2wf0ZY0Beta-secretase 13.4.23.460.445
4gid0GHBeta-secretase 13.4.23.460.445
1p4aPCPPur operon repressor/0.444
1y56ATPUncharacterized protein/0.444
2amt1AA2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase4.6.1.120.444
3fwrADPTranscriptional repressor CcpN/0.444
4d89BXDBeta-secretase 13.4.23.460.444
4dpi0N1Beta-secretase 13.4.23.460.444
2b4yAPRNAD-dependent protein deacylase sirtuin-5, mitochondrial/0.443
2b9yFADPutative aminooxidase/0.443
3fx6BPXCarboxypeptidase A13.4.17.10.443
3qlrNDPDihydrofolate reductase1.5.1.30.443
4eueNAITrans-2-enoyl-CoA reductase [NADH]/0.443
4kx6FADFumarate reductase flavoprotein subunit1.3.5.40.443
4tm0FADKtzI/0.443
1pr9NAPL-xylulose reductase1.1.1.100.442
2j08FADDeoxyribodipyrimidine photo-lyase4.1.99.30.442
2xrlDXTTetracycline repressor protein class D/0.442
3ivcFG4Pantothenate synthetase6.3.2.10.442
4b68FADL-ornithine N(5)-monooxygenase/0.442
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.442
5hg0SAMPantothenate synthetase/0.442
1kfcIPLTryptophan synthase alpha chain/0.441
2vojNADAlanine dehydrogenase1.4.1.10.441
5jlaNADPutative short-chain dehydrogenase/reductase/0.441
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2aa3AP0L-lactate dehydrogenase/0.440
2babFADPutative aminooxidase/0.440
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.440
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.440
3uoyFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.440
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.440
4nbwNADShort-chain dehydrogenase/reductase SDR/0.440
4pt0NADAldehyde dehydrogenase/0.440